Publications:

Qi, Y., Schoene, N.W., Lartey, F.M., and Cheng, W.-H., Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.  J. Biol. Chem. 2010, Online doi:101074jbc.M110.137406.

Shih, R. S. M., Wong, S. H. K., Schoene, N. W., Zhang, J. J. and Lei, K. Y.  Enhanced Gadd45 expression and delayed G2/M progression are p53 dependent in zinc- supplemented human bronchial epithelial cells. Exp. Biol. Med. (Maywood). 235 (8):932-940, 2010.

Wu, M., Kang, M.M., Schoene, N.W. and Cheng, W.H.  Selenium compounds activate                        early barriers of tumorigenesis.  J. Biol. Chem. 285(16):12055-12062, 2010.

Wang, T.T., Schoene, N.W., Kim, Y.S., Mizuno, C.S., and Rimando, A.M.  Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen responsive LNCaP cancer cells.  Mol. Nutr. Food Res.  54(3):335-344, 2010.

Zhang, J.J., Wu, M., Schoene, N. W., Cheng, W. H., Wang, T.T, Alshatwi, A. A., Alsaif, M. and Lei, K. Y.  Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells.  Am. J. Physiol. Cell Physiol. 297(3):C632-644, 2009.

Han, C. T., Schoene, N.W. and Lei, K.Y.  Influence of zinc deficiency on Akt-Mdm2-p53 and Akt-p21 signaling axes in normal and malignant human prostate cells. Am. J. Physiol. Cell Physiol. 297(5):C1188-99, 2009.

Payton-Stewart, F., Schoene, N.W., Kim, Y.S., Burow, M.E., Cleveland, T.E., Boue, S.M. and Wang, T.T.Y.  Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP.  Mol. Carcinog.  48:862-871, 2009.

Schoene, N.W., Kelly, M.A., Polansky, M.M.and Anderson RA.  A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest.  J. Nutr. Biochem. 20:614-620, 2009.

Wong, S.H., Shih, R.S., Schoene, N.W. and Lei K.Y.  Zinc-induced G2/M blockage is p53 and p21 dependent in normal human bronchial epithelial cells.  Am. J. Physiol. Cell Physiol. 294(6):C1342-9, 2008.

Shih, R.S.M., Wong, S.H.K., Schoene, N.W. and Lei, K.Y.  Suppression of Gadd45 alleviates the G2/M blockage and the enhanced phosphorylation of p53 and p38 in zinc supplemented normal human bronchial epithelial cells.  Exp. Biol. Med. 233 (3):317-27, 2008.

Wong, S.H., Zhao, Y., Schoene, N.W., Han, C.T., Shih, R.S. and Lei, K.Y.  Zinc deficiency depresses p21 gene expression: Inhibition of cell cycle progression is independent of the decrease in p21 protein level in HepG2 cells.  Am. J. Physiol. Cell Physiol. 292:(96):C2175-C2184, 2007.

Park, J.P. and Schoene, N.W.  Clovamide-type phenylpropenoic acid amides, N-coumaroyldopamine and N-caffeoyldopamine, inhibit platelet-leukocytes interactions via suppressing  P-selectin expression.  J. Pharmacol. Exp. Ther. 317(2):813-9, 2006.

Ashatwi, A.A., Cui, L., Han, C., Schoene, N.W. and Lei, K.Y.  Role of Mdm2, Mdmx and c-Abl in p53 nuclear accumulation in zinc depleted human hepatoblastoma cells.  Exp. Biol. Med. 231:611-8, 2006.

Schoene, N.W., Kelly, M.A., Polansky, M.M. and Anderson, R.A.  Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell lines.  Cancer Lett. 230:134-140, 2005.

Anderson, R.A., Broadhurst, C.L., Polansky, M.M., Schmidt, W.F., Khan, A., Flanagan, V.P., Schoene, N.W. and Graves, D.J.  Isolation and characterization of polyphenol polymers from cinnamon with insulin-like biological activity.  J. Ag. Food Chem.  52:65-70, 2004.

Malik, M., Zhao, C., Schoene, N., Guisti, M., Moyer, M.P., Magnuson, B.A.  Anthocyanin-rich extract from Aronia meloncarpa E. induces a cell cycle block in colon cancer but not normal colonic cells.  Nutr. Cancer. 46:186-196, 2003.

Park, J.B. and Schoene, N.W.  Synthesis and characterization of N-coumaroyltyramine as a potent phytochemical which arrests human transformed cells via inhibiting protein tyrosine kinases.  Biochem. Biophys. Res. Commun.  292:1104-1110, 2002.

Cui, L., Schoene, N.W., Zhu, L., Fanzo, J.C., Alshatwi, A. and Lei, K.Y.   Zinc depletion reduced EGR-1 and HNF-3 beta expression and apolipoprotein A-I promoter activity in Hep G2 cells.  Am. J. Physiol.Cell Physiol.  283:C623-C630, 2002.

Park, Y, Schoene, N.W. and Harris, W.S.  Mean platelet volume as an indicator of platelet activation:  methodological issues.  Platelets. 13:301-306, 2002.

Solano-Aguilar, G., Beshah, E.,  Morimoto, M., Schoene, N.W. and Urban, J.  Localized immunity to the large roundworm ascaris suum in swine. Proceedings of Allen D. Leman Swine Conference  Vol 28, pp 91-93, September, 2001.

Schoene, N.W.  Vitamin E and omega-3 fatty acids: effectors of platelet responsiveness.  Nutrition 17:793-796, 2001.

Schoene, N.W. and  Guidry, C.A.  Genistein inhibits reactive oxygen species production (ROS), shape change, and aggregation in rat platelets.  Nutr. Res. 20:47-58, 2000.

Schoene, N.W.  Detecting ROS in cells using flow cytometry.  In: Models and Methods in Cell Signaling and Gene Expression: Applications to Oxidative Stress Research, eds. T.M.Bray and N.W. Schoene, OICA International, London, pp 131-134, 1999.

Schoene, N.W. and  Kamara, K.S.  Population doubling time, phosphatase activity and hydrogen peroxide generation in Jurkat cells.  Free Rad. Biol. Med.  27:364-369, 1999.

Schoene, N.W. and Guidry, C.A.  Dietary soy isoflavones inhibit activation of rat platelets.  J. Nutr. Biochem. 10:421-426, 1999.

Schoene, N.W.  Design criteria: tests used to assess platelet function.  Am. J. Clin. Nutr.  65(suppl):16658S-1668S, 1997.

Podczasy, J., Church, J.P. and Schoene, N.W.  Effects of dietary fish oil on calcium homeostasis in rat platelets.  J. Nutr. Biochem. 6:327-333, 1995.

Schoene, N.W., Allman, M.A., Dougherty, R.M., Denvir, E. and Iacono, J.M.  Diverse effects of dietary stearic and palmitic acids on platelet morphology.  In:  Essential Fatty Acids and Eicosanoids, eds. A. Sinclair and R. Gibson, AOCS, Champaign, IL, pp. 290-292, 1993.

Schoene, N.W. and Fitzgerald, G.A.  Session Summary - Thrombosis.  Am. J. Clin. Nutr. 56:825S-826S, 1992.

Kramer, T.R., Schoene, N.W., Douglass, L.W., Judd, J.T., Ballard-Barbash, R. Taylor, P.R., Bhagavan, H.N., and Nair, P.P.  Increased vitamin E intake restores suppressed proliferation of mitogen stimulated T-lymphocytes.  Am. J. Clin. Nutr.  54: 896-902, 1991.

Vanderhoek, J.Y., Schoene, N.W. and Pham, P-P.T.  The inhibitory potencies of fish oil hydroxy fatty acids on cellular lipoxygenases and platelet aggregation.  Biochem. Pharmacol. 42:959-962, 199l.

Schoene, N.W.  Dietary fatty acids and platelet function:  Mechanisms.  In: Health Effects of Dietary Fatty Acids, ed. G. Nelson, AOCS, Champaign, IL, pp. 129-135, 1991.

Schoene, N.W. and Church, J.P.  Differential effects of dietary fats on aggregation of platelets from rats. Nutr. Res. 11:479-489,  1991

Fair, P., Salem, N., and Schoene, N.  NOAA Technical Memorandum, Biomedical Test Materials Program:  Feasibility on the Microencapsulation of Fish Oil and n-3 Concentrate. 1989.

Schoene, N.W., Church, J.P., Michaelis, O.E. IV, Carswell, N., and Hansen, C.T.  Dietary fat, plasma lipids and platelet function.  In:  New models of genetically obese rats for studies in diabetes, heart disease and complications of obesity, eds. O.E. Michaelis, IV, and C.T. Hansen, NIH, Bethesda, MD, pp 65-69, 1988.

Schoene, N.W., and Church, J.P.  Dietary fatty acids and signal transduction in platelets.  In:  Polyunsaturated Fatty Acids and Eicosanoids, ed. W.E.M. Lands, AOCS, Champaign, IL, pp 358-359, 1987.

Schoene, N.W., Chanmugam, P. and Reynolds, R.D.  Effect of oral vitamin B-6 supplementation on in vitro platelet aggregation.  Am. J. Clin. Nutr. 43:825-830. 1986.

Schoene, N.W., Morris, V.C. and Levander, O.A.  Effects of selenium deficiency on arachidonic acid metabolism and aggregation in rat platelets.  In:  Prostaglandins, Leukotrienes and Lipoxins, ed. J.M.Bailey, Plenum Press, New York, pp 379-385, 1985.

Schoene, N.W.  Selenium-dependent glutathione peroxidase and eicosanoid production. In:  Biochemistry of Arachidonic Acid Metabolism, ed. W.E.M. Lands, Martinus Nijhoff, Boston,  pp. 151-159, 1985.

Michaelis, O.E. IV, Ellwood, K.C., Judge, J.M., Schoene, N.W. and Hansen, C.T.  Effect of dietary sucrose on the SHR/N-corpulent rat:  a new model for insulin-independent diabetes.  Am. J. Clin. Nutr. 39:612-618, 1984.

Schoene, N.W. and Fiore, D.  Effect of a diet containing fish oil on blood pressure in spontaneously hypertensive rats.  Progress in Lipid Research. 20:569-570, 1982.

Schoene, N.W., Ferretti, A. and Fiore, D.  Production of prostaglandins in homogenates of kidney medullae and cortices of spontaneously hypertensive rats fed menhaden oil.  Lipids. 16:866-869, 1981.

 Ferretti, A., Schoene, N.W. and Flanagan, V.P.  Identification and quantitation of prostaglandin E₃ in renal medullary tissue of three strains of rats fed fish oil.  Lipids. 16:800-804, 1981. 

Schoene, N.W., Marshall, M.W., Judd, J.T., Reeves, V. and Carvalho, A.  Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets.  Advances in Prostaglandin and Thromboxane Research. 8:1787-1789, 1980.

Schoene, N.W., Reeves, V.B. and Ferretti, A.  Effects of dietary linoleic acid on the biosynthesis of PGE₂ and PGF₂ in kidney medullae in spontaneously hypertensive rats.  Advances in Prostaglandin and Thromboxane Research. 8:1791-1782, 1980.

Schoene, N.W.  Properties of platelet phospholipase A₂.  Advances in Prostaglandin and Thromboxane Research. 3:121-125, 1978.

Lehmann, J., Schoene, N.W. and Church, J.P.  Essential fatty acid deficiency and platelet fatty acids of normotensive and genetically hypertensive rats.  Prostaglandins. 13:583-586, 1977.   

Schoene, N.W. and Iacono, J.M.  The influence of phospholipase A₂ production in platelets.  Advances in Prostaglandin and Thromboxane Research. 2:763-766, 1976. 

Schoene, N.W. and Iacono, J.M.  Use of lysed human platelets to study prostaglandin E₂ production.  Prostaglandins. 5:387-396, 1974. 

Iacono, J.M., Binder, R.A., Marshall, M.W., Schoene, N.W., Jencks, J. and Mackin, J.  Decreased susceptibility to thrombin and collagen platelet aggregation in men fed a low fat diet.  Haemostasis. 3:306-318, 1974.