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United States Department of Agriculture

Agricultural Research Service

Related Topics

William T Golde (Bill)
Foreign Animal Disease Research
Microbiologist

Phone: (631) 323-3249
Fax: (631) 323-3006
40550 ROUTE 25
ORIENT POINT, NY, 11957

Projects
INTERVENTION STRATEGIES TO SUPPORT THE GLOBAL CONTROL AND ERADICATION OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV)
Appropriated (D)
  Accession Number: 422203
Analysis of duration of immunity of cattle to Ad5-FMD vaccine, the newly licensed vaccine for FMDV
Interagency Reimbursable Agreement (I)
  Accession Number: 424819
A MODERN APPROACH FOR THE DEVELOPMENT OF CATTLE VACCINES FOR CRITICAL BOVINE DISEASES IMPACTING SMALLHOLDER FARMS IN SUB-SAHARAN AFRICA
Nonfunded Cooperative Agreement (N)
  Accession Number: 420649
COUNTERMEASURES FOR FOOT-AND-MOUTH DISEASE UTILIZING DIAGNOSTICS, BIOTHERAPEUTICS, A NOVEL VACCINE PLATFORM AND IMPROVED CHALLENGE SYSTEMS
Reimbursable (R)
  Accession Number: 421628
IN VITRO EVALUATION OF THE CAPACITY OF FOOT-AND-MOUTH DISEASE VIRUS TO INITIATE T-INDEPENDENT HUMORAL RESPONSES IN A BOVINE MODEL
Specific Cooperative Agreement (S)
  Accession Number: 423165
Duration of Immunity to Vaccination of Cattle with Human Ad5FMDV Vaccine
Specific Cooperative Agreement (S)
  Accession Number: 424217
Determination of Duration of Immunity Conferred by Ad5FMDV Vaccination in Cattle
Specific Cooperative Agreement (S)
  Accession Number: 426604
DEVELOPMENT OF MONOCLONAL ANTIBODIES FOR ANALYSIS OF IMMUNE RESPONSES IN LIVESTOCK
Specific Cooperative Agreement (S)
  Accession Number: 420617

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic - (Review Article)
Butler, J.E., Lager, K.M., Golde, W., Faaberg, K.S., Sinkora, M., Loving, C., Zhang, Y.I. 2014. Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research. 59(1-3):81-108.
Characterization of cytotoxic T lymphocyte function following foot-and-mouth disease virus infection and vaccination - (Peer Reviewed Journal)
Patch, J.R., Kenney, M.A., Pacheco Tobin, J., Grubman, M.J., Golde, W.T. 2013. Characterization of cytotoxic T lymphocyte function following foot-and-mouth disease virus infection and vaccination. Viral Immunology. 26(4):239-249 DOI:10.1089/vim.2013.0011.
Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity Reprint Icon - (Review Article)
Toka, F.N., Golde, W.T. 2013. Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity. Immunology Letters. 152(2):135-143 DOI:10.1016/j.imlet.2013.05.007.
Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401 Reprint Icon - (Peer Reviewed Journal)
Pedersen, L.E., Harndahl, M., Nielsen, M., Patch, J.R., Jungersen, G., Buus, S., Golde, W.T. 2012. Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401. Animal Genetics. 44(3):251-258. DOI: 10.1111/j.1365-2052.2012.02400.x
An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV) Reprint Icon - (Peer Reviewed Journal)
Pandya, M., Pacheco Tobin, J., Bishop, E.A., Kenney, M.A., Milward, F., Doel, T., Golde, W.T. 2012. An alternate delivery system improves vaccine performance against foot-and-mouth disease virus (FMDV). Vaccine. 30(20):3106-3111.
Designing bovine T-cell vaccines via reverse immunology - (Review Article)
Nene, V., Svitek, N., Golde, W.T., Barlow, J., Buus, S., Nielsen, M. 2012. Designing bovine T-cell vaccines via reverse immunology. Ticks and Tick Borne Diseases. 3(2012):188-192.
Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities - (Peer Reviewed Journal)
Pedersen, L.E., Harndahl, M.N., Rasmussen, M., Lamberth, K., Golde, W.T., Lund, O., Nielsen, M., Buus, S. 2011. Porcine major histocompatibility complex (MHC) class I molecules and analysis of their peptide-binding specificities. Immunogenetics. 63(12):821-831.
Rapid and transient activation of gamma/delta T cells to interferon gamma production, NK cell-like killing and antigen processing during acute virus infection - (Peer Reviewed Journal)
Toka, F.N., Kenney, M.A., Golde, W.T. 2011. Rapid and transient activation of gamma/delta T cells to interferon gamma production, NK cell-like killing and antigen processing during acute virus infection. Journal of Immunology. 186(8):4853-4861.
Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus - (Review Article)
Golde, W.T., De Los Santos, T.B., Robinson, L., Grubman, M.J., Sevilla, N., Summerfield, A. 2011. Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus. Transboundary and Emerging Diseases. 58(4):283-290.
Induction of foot-and-mouth disease virus specific cytotoxic T cell killing by vaccination - (Peer Reviewed Journal)
Patch, J.R., Pederesen, L.E., Moraes, M.P., Grubman, M.J., Nielsen, M., Buus, S., Golde, W.T. 2011. Induction of foot-and-mouth disease virus specific cytotoxic T cell killing by vaccination. Clinical and Vaccine Immunology. 18(2):280-288.
IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination Reprint Icon - (Review Article)
Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus infection and vaccination. Clinical and Vaccine Immunology. p. 550-558.
IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination - (Peer Reviewed Journal)
Pacheco Tobin, J., Butler, J.E., Jew, J., Ferman, G.S., Zhu, J.J., Golde, W.T. 2010. IgA antibody response of swine to foot-and-mouth disease virus (FMDV) infection and vaccination. Clinical and Vaccine Immunology. 17(4):550-558.
Mutations in the classical swine fever virus NS4B protein affects virulence in swine - (Abstract Only)
Fernandez Sainz, I., Gladue, D.P., Holinka-Patterson, L.G., O'Donnell, V.K., Gudmundsdottir, I., Prarat, M.V., Patch, J.R., Golde, W.T., Zhiqiang, L., Risatti, G.R., Zhu, J.J., Borca, M.V. 2009. Mutations in the classical swine fever virus NS4B protein affects virulence in swine. Proceedings. P. 143.
Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease infection - (Peer Reviewed Journal)
Nfon, C.K., Toka, F.N., Kenney, M.A., Pacheco Tobin, J., Golde, W.T. 2010. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease infection. Viral Immunology. 23(1):29-41.
Mutations in classical swine fever virus NS4B affect virulence in swine - (Peer Reviewed Journal)
Fernandez-Sainz, I., Gladue, D.P., Holinka-Patterson, L.G., O'Donnell, V.K., Gudmundsdottir, I., Prarat, M.V., Patch, J.R., Golde, W.T., Lu, Z., Risatti, G.R., Zhu, J.J., Borca, M.V. 2010. Mutations in classical swine fever virus NS4B affect virulence in swine. Journal of Virology. 84(3):1536-1549.
Natural killer cell dysfunction during acute infection with foot-and-mouth diseaase virus - (Peer Reviewed Journal)
Toka, F.N., Nfon, C., Dawson, H.D., Golde, W.T. 2010. Natural killer cell dysfunction during acute infection with foot-and-mouth diseaase virus. Clinical and Vaccine Immunology. 16(12):1738-1749.
Innate Immune Defenses Induced by CpG do not Promote Vaccine-Induced Protection Against Foot-and-Mouth Disease in Pigs - (Peer Reviewed Journal)
Alves, M.P., Guzylack-Piriou, L., Juillard, V., Audonnet, J.C., Doel, T., Dawson, H.D., Golde, W.T., Gerber, H., Peduto, N., Mccullough, K.C., Summerfield, A. 2009. Innate Immune Defenses Induced by CpG do not Promote Vaccine-Induced Protection Against Foot-and-Mouth Disease in Pigs. Clinical and Vaccine Immunology. 16(8):1151-1157.
Accessory Cell Mediated Activation of Porcine NK Cells by TLR7 and TLR8 Agonists - (Peer Reviewed Journal)
Toka, F.N., Nfon, C., Dawson, H.D., Golde, W.T. 2009. Accessory Cell Mediated Activation of Porcine NK Cells by TLR7 and TLR8 Agonists. Clinical and Vaccine Immunology.Vol.16. No. 6.: 866-878.
Langerhans Cells in Porcine Skin - (Peer Reviewed Journal)
Nfon, C.K., Toka, F.N., Dawson, H., Golde, W.T. 2008. Langerhans Cells in Porcine Skin. Veterinary Immunology and Immunopathology. 126:236-247.
Immune Evasion During Foot-and-Mouth Disease Virus (FMDV) Infection of Swine - (Review Article)
Golde, W.T., Nfon, C.K., Toka, F.N. 2008. Immune Evasion During Foot-and-Mouth Disease Virus (FMDV) Infection of Swine. Review Article. 225:85-95.
Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149
Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV) - (Abstract Only)
Toka, F., Nfon, C.K., Golde, W.T. 2008. Suppression of Swine NK Cell Function During Acute Infection with Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. P 94
Interferon Alpha Production by Circulating Dendritic Cells is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus (FMDV) - (Peer Reviewed Journal)
Nfon, C., Ferman Ii, G.S., Toka, F., Golde, W.T. 2008. Interferon Alpha Production by Circulating Dendritic Cells is Inhibited During Acute Infection with Foot-and-Mouth Disease Virus (FMDV). Viral Immunology. 21:68-77.
Evasion of the Innate Response of Circulation DC Populations by Foot-and-Mouth Disease Virus - (Abstract Only)
Nfon, C.K., Ferman Ii, G.S., Golde, W.T. 2007. Evasion of the Innate Response of Circulation DC Populations by Foot-and-Mouth Disease Virus. 94th Annual Meeting of The American Association of Immunologists, Inc., P 21
Natural Killer Cells in Foot-and-Mouth Disease Virus Infection - (Abstract Only)
Toka, F., Nfon, C.K., Endsley, J., Ferman Ii, G.S., Estes, D., Golde, W.T. 2007. Natural Killer Cells in Foot-and-Mouth Disease Virus Infection. 94th Annual Meeting of The American Association of Immunologists, Inc., P 22
Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine - (Abstract Only)
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30
Il-13 Replaces Il-4 in Development of Monocyte Derived Dendritic Cells (Modc) of Swine; the Innate Immune Response of Modc to Toll-Like Receptor Agonists - (Peer Reviewed Journal)
Bautista, E.M., Nfon, C., Ferman Ii, G.S., Golde, W.T. 2007. Il-13 replaces il-4 in development of monocyte derived dendritic cells (modc) of swine; the innate immune response of modc to toll-like receptor agonists. Veterinary Immunology and Immunopathology. 115:56-67.
Infection with Foot-and-Mouth Disease Virus Causes Loss of Circulating Plasmacytoid Dendritic Cells and Abrogates the Interferon Alpha Response to Tlr Agonists - (Abstract Only)
Golde, W.T., Nfon, C. 2006. Infection with Foot-and-Mouth Disease Virus Causes Loss of Circulating Plasmacytoid Dendritic Cells and Abrogates the Interferon Alpha Response to TLR Agonists. 9th International Conference on Dendritic Cells, September 16, 2006. Poster 4.022, P.89.
Novel Approach for Identification of Class I Restricted T Cell Epitopes of Foot-and-Mouth Disease Virus - (Abstract Only)
Ferman Ii, G.S., Golde, W.T. 2006. Novel approach for identification of class i restricted t cell epitopes of foot-and-mouth disease virus. Keystone Symposia. 2006 P. 63
Determination of Antibody Class and Subclass Following Foot-and-Mouth Disease Virus (Fmdv) Infection Or Vaccination with Killed Virus Vaccine - (Abstract Only)
Pacheco, J.M., Ferman Ii, G.S., Golde, W.T. 2006. Determination of antibody class and subclass following foot-and-mouth disease virus (fmdv) infection or vaccination with killed virus vaccine. Keystone Symposia. 2006. P.84
Innate Immune Responses of Monocyte Derived Dendritic Cells (Modc) to Foot-and-Mouth Disease Virus (Fmdv) - (Abstract Only)
Nfon, C., Bautista, E.M., Ferman Ii, G.S., Golde, W.T. 2006. Innate immune responses of monocyte derived dendritic cells (modc) to foot-and-mouth disease virus (fmdv). Keystone Symposia. 2006. P.82
Immunopotentiation of a Foot-and-Mouth Disease Virus Subunit Vaccine by Interferon Alpha - (Peer Reviewed Journal)
Botton, S.D., Brum, M.C., Bautista-Peck, E.M., Koster, M.J., Weiblen, R., Golde, W.T., Grubman, M.J. 2006. Immunopotentiation of a foot-and-mouth disease virus subunit vaccine by interferon alpha. Vaccine. (2006) 24: 3446-3456.
A Lancet Designed for the Simple and Humane Cheek Pouch Bleeding of Mice - (Peer Reviewed Journal)
Golde, W.T., Gollobin, P., Rodriguez, L.L. 2005. A Lancet Designed for the Simple and Humane Cheek Pouch Bleeding of Mice. Lab Animal. Vol. 34:9, P. 39-43.
Vaccination Against Foot-and-Mouth Disease Virus Confers Complete Clinical Protection in 7 Days and Partial Protection in 4 Days:use in Emergency Outbreak Response - (Peer Reviewed Journal)
Golde, W.T., Pacheco-Tobin, J., Duque, H., Doel, T., Penfold, B., Ferman Ii, G.S., Gregg, D.A., Rodriguez, L.L. 2005. Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days:use in emergency outbreak response. Vaccine 23 (2005) 5775-5782.
Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (Fmdv) by a Single Inoculaiton with An Adenovirus Vectored Fmdv Subunit Vaccine - (Peer Reviewed Journal)
Pacheco, J., Brum, M., Moraes, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by a Single Inoculaiton with an Adenovirus Vectored FMDV Subunit Vaccine. Virology. 337: P205-209.
Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (Fmdv) by Inoculation with An Adenovirus Vectored Fmdv Subunit Vaccine - (Abstract Only)
Pacheco, J.M., Brum, M.C., Moraes, M.P., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. European Study Group on the Molecular Biology of Picornaviruses (ERUOPIC) 2005. P. I22.
Difference of Antibody Isotype (Iga) Production after Foot-and-Mouth Disease Virus Vaccination Or Infection in Pigs - (Abstract Only)
Pacheco, J.M., Ferman Ii, G.S., Golde, W.T. 2005. Difference of Antibody Isotype (IGA) Production after Foot-and-Mouth Disease Virus Vaccination or Infection in Pigs. American Society for Virology 24th Annual Meeting. P. P18-1.
Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (Fmdv) by Inoculation with An Adenovirus Vectored Fmdv Subunit Vaccine - (Abstract Only)
Moraes, M., Pacheco, J., Brum, M., Golde, W.T., Grubman, M.J. 2005. Rapid Protection of Cattle from Direct Challenge with Foot-and-Mouth Disease Virus (FMDV) by Inoculation with an Adenovirus Vectored FMDV Subunit Vaccine. American Society for Virology 24th Annual Meeting. P. P9-5.
Novel Tools to Prevent and Eradicate Foreign Animal Diseases - (Abstract Only)
Rodriguez, L.L., Baxt, B., Rieder, A.E., Golde, W.T., Borca, M.V., Grubman, M.J. 2005. Novel tools to prevent and eradicate foreign animal diseases. American Society for Microbiology Biodefense Meeting. p 41.
Porcine Il-13 Replaces Il-4 in Development of Dendritic Cells from Peripheral Blood - (Proceedings)
Bautista Peck, E.M., Ferman Ii, G.S., Golde, W.T. 2005. Porcine IL-13 Replaces IL-4 in Development of Dendritic Cells from Peripheral Blood. Annual Meeting of the American Society of Immunology, Experimental Biology 2005. 256.1, P. 97.
Constitutive Expression of Ifn-Alpha by Porcine Skin Dendritic Cells Confers Resistance to Infection by Foot-and-Mouth Disease Virus (Fmdv) - (Peer Reviewed Journal)
Bautista Peck, E.M., Ferman Ii, G.S., Gregg, D.A., Brum, M.C., Grubman, M.J., Golde, W.T. 2005. Constitutive Expression of IFN-alpha by Porcine Skin Dendritic Cells Confers Resistance to Infection by Foot-and-Mouth Disease Virus (FMDV). Journal of Virology 79 (8). P 4838-4847.
The Effect of Granulocyte-Macrophage Colony-Stimulating Factor on the Efficacy of a Foot-and-Mouth Disease Virus Subunit Vaccine - (Peer Reviewed Journal) - (04-Nov-04)
Cross Reaction of Anti-Human Cd Monoclonal Antibodies on Swine Cells: a Summary of the Swine Secton of the Hlda8 Animal Homologues Data - (Abstract Only)
Lunney, J.K., Aasted, B., Dominguez, J., Alvarez, B., Revilla, C., Ezquerra, A., Alonso, F., Haverson, K., Golde, W.T., Kuhar, D.J. 2004. Cross reaction of anti-human cd monoclonal antibodies on swine cells: a summary of the swine secton of the hlda8 animal homologues data. Meeting Abstract.
Early Development of Adenovirus-Vectored Fmd Vaccine and Antiviral - (Abstract Only)
Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early development of adenovirus-vectored fmd vaccine and antiviral. Meeting Abstract.
Vesicular Stomatitis New Jersey Virus in Cattle: Pathogenesis, Virus Distribution and Local Immune Response - (Abstract Only)
Scherer, C.F., Golde, W.T., Gregg, D.A., Estes, D.M., Drolet, B.S., Rodriguez, L.L. 2004. Vesicular Stomatitis New Jersey Virus in Cattle: Pathogenesis, Virus Distribution and Local Immune Response. Conference of Research Workers in Animal Disease Annual Meeting. P. 198.
Early Development of Adenovirus-Vectored Fmd Vaccine and Antiviral - (Abstract Only)
Grubman, M.J., Golde, W.T., Rodriguez, L.L. 2004. Early Development of Adenovirus-vectored FMD Vaccine and Antiviral. European Commission for the Control of Foot-and-Mouth Disease, Chania, Crete, Greece. P. 45.
Interactions of Foot-and-Mouth Disease Virus with Soluble Bovine Alphavbeta3 and Alphavbeta6 Integrins - (Peer Reviewed Journal)
Duque, H., Larocco, M., Golde, W.T., Baxt, B. 2004. Interactions of foot-and-mouth disease virus with soluble bovine alphavbeta3 and alphavbeta6 integrins. Journal of Virology. 78:9773-9781.
A Synthetic Peptide Containing the Consensus Sequence of the G-H Loop Region of Fmdv Type O Vp1 Combined with a Promiscuous T-Helper Epitope Induces Peptide-Specific Ab But Fails to Protect Cattle Against Viral Challenge - (Peer Reviewed Journal)
RODRIGUEZ, L.L., BARRERA, J.D., KRAMER, E., LUBROTH, J., BROWN, F., GOLDE, W.T. A SYNTHETIC PEPTIDE CONTAINING THE CONSENSUS SEQUENCE OF THE G-H LOOP REGION OF FMDV TYPE O VP1 COMBINED WITH A PROMISCUOUS T-HELPER EPITOPE INDUCES PEPTIDE-SPECIFIC AB BUT FAILS TO PROTECT CATTLE AGAINST VIRAL CHALLENGE. VACCINE, VOLUME 21: 3751-3756, 2003.
Induction of Lymphopenia and Inhibiition of T Cell Function During Acute Infection of Swine with Foot and Mouth Disease Virus (Fmdv) - (Peer Reviewed Journal)
BAUTISTA, E.M., FERMAN II, G.S., GOLDE, W.T. INDUCTION OF LYMPHOPENIA AND INHIBIITION OF T CELL FUNCTION DURING ACUTE INFECTION OF SWINE WITH FOOT AND MOUTH DISEASE VIRUS (FMDV). VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. Vol 92: 61-73, 2003.
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Last Modified: 11/23/2014
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