Projects

INTERVENTION STRATEGIES TO CONTROL VIRAL DISEASES OF SWINE Appropriated (D)   Accession Number: 421208

INFLUENZA PANDEMIC PREPAREDNESS Interagency Reimbursable Agreement (I)   Accession Number: 423861

USDA SWINE INFLUENZA VIRUS SURVEILLANCE SYSTEM: IN VIVO PATHOGENESIS AND TRANSMISSION AND ASSOCIATED IN VITRO STUDIES Reimbursable (R)   Accession Number: 422887

IMMUNE FACTORS IN VACCINE-ENHANCED PANDEMIC H1N1 INFLUENZA DISEASE Reimbursable (R)   Accession Number: 423110

ASSESSMENT OF HETEROCLITE-VECTORED CYTOKINES AS A MEANS TO INCREASE EFFICIENCY OF MODIFIED LIVE PRRSV DIVA VACCINE PREPARATIONS Reimbursable (R)   Accession Number: 423595

H1N1 INFLUENZA A VIRUS IN SWINE SUPPLEMENTAL RESEARCH PROGRAM Specific Cooperative Agreement (S)   Accession Number: 419005

SIV EPITOPES AND GENETIC FACTORS THAT AFFECT SURVEILLANCE AND IMMUNITY ELICITED BY INFLUENZA VACCINES AGAINST EMERGING INFLUENZA STRAINS Specific Cooperative Agreement (S)   Accession Number: 419073

DEVELOPMENT OF AN ORAL VACCINE VECTOR FOR INFECTIOUS DISEASES OF ANIMALS Specific Cooperative Agreement (S)   Accession Number: 419984

H1N1 INFLUENZA A VIRUS IN SWINE SUPPLEMENTAL RESEARCH PROGRAM Other (X)   Accession Number: 418864

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with influenza A virus - (Abstract Only)

Miller, L.C., Jiang, Z., Sang, Y., Harhay, G.P., Lager, K.M. 2013. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with influenza A virus. Second Annual Great Plains Emerging Infectious Diseases Conference. p. 23.

A divergent picornavirus from a turkey with gastro-intestinal disease - (Peer Reviewed Journal)

Ng, T.F.F., Cheung, A.K., Wong, W., Lager, K.M., Kondov, N.O., Cha, Y., Murphy, D.A., Pogranichniy, R.M., Delwart, E. 2013. Divergent picornavirus from a turkey with gastro-intestinal disease. Genome Announcements. 1(3):e00134-13.

Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Abstract Only) - (22-Mar-13)

Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1 - (Abstract Only)

Lin, K., Vincent, A.L., Roth, J.A., Kehrli, Jr., M.E., Lager, K.M., Ramamoorthy, S. 2013. Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1. In: Proceedings of the 16th Annual Conference on Vaccine Research. April 22-24, Baltimore, Maryland. p. 115.

Pathogenicity and transmission of the novel A (H3N2v) influenza virus isolated from humans in experimentally inoculated pigs - (Abstract Only) - (15-Feb-13)

The use of epitope tags in modified porcine respiratory and reproductive syndrome virus vaccines to differentiate infected from vaccinated animals - (Abstract Only)

Spear, A.R., Lager, K.M., Faaberg, K.S. 2013. The use of epitope tags in modified porcine respiratory and reproductive syndrome virus vaccines to differentiate infected from vaccinated animals. Positive Strand RNA Viruses, Keystone Symposia on Molecular and Cellular Biology. Paper No. 2079, p. 94.

Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? - (Proceedings)

Kehrli, Jr., M.E., Vincent, A.L., Gauger, P.C., Kitikoon, P., Anderson, T.K., Loving, C.L., Lager, K.M. 2013. Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? In: Proceedings of 44th Annual Meeting of the American Association of Swine Veterinarians, San Diego, CA. p. 517-519.

Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection - (Abstract Only)

Miller, L.C., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2013. Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection [abstract]. International Plant & Animal Genome XXI, January 12-16, 2013, San Diego, California. Paper No. W756.

Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors - (Peer Reviewed Journal)

Sun, X., Wertz, N., Lager, K.M., Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors. Vaccine. 31(1):141-148.

Pathogenesis of HP-PRRSV in gnotobiotic pigs - (Abstract Only)

Lager, K.M., Faaberg, K.S., Brockmeier, S.L., Miller, L.C., Kappes, M.A., Spear, A., Kehrli, Jr., M.E. 2012. Pathogenesis of HP-PRRSV in gnotobiotic pigs. 2012 International PRRS Symposium. p. 92.

Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Abstract Only)

Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus. 2012 International PRRS Symposium. p. 96.

Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes - (Peer Reviewed Journal)

Butler, J.E., Sun, X., Wertz, N., Vincent, A.L., Zanella, E.L., Lager, K.M. 2013. Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes. Immunology. 138(2):134-144.

Infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Guo, B., Lager, K.M., Henningson, J.N., Miller, L.C., Schlink, S.N., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Yang, H., Faaberg, K.S. 2013. Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology. 435(2):372-384.

Biotherapeutics as alternatives to antibiotics: Effects of adenoviral delivered cytokines on innate and adaptive immunity - (Abstract Only) - (12-Sep-12)

Diversity of viruses detected by deep sequencing in pigs from a common background - (Peer Reviewed Journal)

Lager, K.M., Ng, T.F., Bayles, D.O., Alt, D.P., Delwart, E.L., Cheung, A.K. 2012. Diversity of viruses detected by deep sequencing in pigs from a common background. Journal of Veterinary Diagnostic Investigation. 24(6):1177-1179.

Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H.-C., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. BioMed Central (BMC) Veterinary Research. 8(1):208. Available: http://www.biomedcentral.com/1746-6148/8/208.

Genomic sequence and virulence comparison of four type 2 porcine reproductive and respiratory syndrome virus strains - (Peer Reviewed Journal)

Brockmeier, S.L., Loving, C.L., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Miller, L.C., Faaberg, K.S. 2012. Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains. Virus Research. 169(1):212-221.

Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine - (Peer Reviewed Journal)

Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Perez, D.R. 2012. Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine. Journal of General Virology. 93(10):2204-2214.

Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease (VAERD) - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Richt, J.A., Janke, B.H., Sandbulte, M.R., Gauger, P.C., Loving, C.L., Webby, R.J., Garcia-Sastre, A. 2012. Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease. Journal of Virology. 86(19):10597-10605.

Biotherapeutics as alternatives to antibiotics: effects of IFN-a and G-CSF on innate and adaptive immunity in swine - (Abstract Only) - (16-Jun-12)

Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 - (Abstract Only)

Cheung, A.K., Kehrli, Jr., M.E., Lager, K.M., Gauger, P.C., Rohrer, G.A., Michael, D.D., Miller, L.C., Vincent, A.L., Braucher, D.R. 2012. Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 [abstract]. IXth International Congress of Veterinary Virology. p. 189-190.

Antibody repertoire development in fetal and neonatal piglets. XXII. Lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine - (Peer Reviewed Journal)

Sun, X., Wertz, N., Lager, K., Sinkora, M., Stepanova, K., Tobin, Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XXII. Lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine. Immunology. 137(2):149-159.

Comparison of 2010-2011 H3N2 influenza A viruses isolated from swine and the A(H3N2)v isolated from humans in 2011 - (Abstract Only)

Kitikoon, P., Vincent, A.L., Gauger, P., Schlink, S.N., Bayles, D.O., Gramer, M., Darnell, D., Webby, R., Lager, K.M., Swenson, S., Klimov, A. 2012. Comparison of 2010-2011 H3N2 influenza A viruses isolated from swine and the A(H3N2)v isolated from humans in 2011 [abstract]. American Society for Virology 31st Annual Meeting. p. 102.

Evaluation of a real-time PCR assay for pseudorabies virus surveillance purposes - (Peer Reviewed Journal)

Zanella, E.L., Miller, L.C., Lager, K.M., Bigelow, T.T. 2012. Evaluation of a real-time polymerase chain reaction assay for pseudorabies virus surveillance purposes. Journal of Veterinary Diagnostic Investigation. 24(4):739-745.

Pathogenicity and transmission in pigs of the novel A(H3N2)v influenza virus isolated from humans and characterization of swine H3N2 viruses isolated in 2010-2011 - (Peer Reviewed Journal)

Kitikoon, P., Vincent, A.L., Gauger, P.C., Schlink, S.N., Bayles, D.O., Gramer, M.R., Darnell, D., Webby, R.J., Lager, K.M., Swenson, S.L., Klimov, A. 2012. Pathogenicity and transmission in pigs of the novel A(H3N2)v influenza virus isolated from humans and characterization of swine H3N2 viruses isolated in 2010-2011. Journal of Virology. 86(12):6804-6814.

Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS virus display the same immune dysregulation seen in isolator piglets - (Peer Reviewed Journal)

Sun, X.Z., Wertz, N., Lager, K.M., Tobin, G., Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS virus display the same immune dysregulation seen in isolator piglets. Vaccine. 30(24):3646-3652.

Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine - (Peer Reviewed Journal)

Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Lorusso, A., Perez, D.R. 2012. Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine. Journal of Virology. 86(10):5523-5532.

Global coordination for swine influenza virus surveillance and research: what are we missing from the big picture? - (Proceedings)

Vincent, A.L., Kitikoon, P., Gauger, P.C., Gramer, M.R., Lorusso, A., Lager, K.M., Ciacci-Zanella, J.R. 2012. Global coordination for swine influenza virus surveillance and research: what are we missing from the big picture? In: Proceedings of the 43rd American Association of Swine Veterinarians Annual Meeting, March 10-13, 2012, Denver, Colorado. p. 507-512.

Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs - (Peer Reviewed Journal)

Kappes, M.A., Sandbulte, M.R., Platt, R., Wang, C., Lager, K.M., Henningson, J.N., Lorusso, A., Vincent, A.L., Loving, C.L., Roth, J.A., Kehrli Jr, M.E. 2012. Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs. Vaccine. 30(2):280-288.

Validation of a real-time PCR assay for pseudorabies virus surveillance purposes - (Abstract Only)

Miller, L.C., Zanella, E.L., Lager, K.M., Bigelow, T.T. 2011. Evaluation of a real-time PCR assay for pseudorabies virus surveillance purposes. Conference of Research Workers in Diseases [abstract]. Paper No. 062P.

Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain - (Abstract Only)

Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Henningson, J.N., Faaberg, K.S., Guo, B., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E. 2011. Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain. 2011 International PRRS Symposium. Paper No. 59. page 76.

Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV - (Abstract Only)

Miller, L.C., Harhay, G., Kehrli, M., Lager, K. 2011. Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV [abstract]. 2011 International PRRS Symposium. Paper No. 51. p. 68.

Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine - (Abstract Only)

Gauger, P., Vincent, A., Loving, C., Lorusso, A., Lager, K., Pena, L., Perez, D. 2011. Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 148.

Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs - (Abstract Only)

Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S.L., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Nicholson, T.L., Yang, H.-C. 2011. Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs [abstract]. 2011 International PRRS Symposium. Paper No. 60. page 77.

Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus - (Abstract Only)

Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Faaberg, K.S. 2011. Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Diseases. Paper No. 174. p. 171.

Antibody repertoire development in fetal and neonatal piglets. XXI. VH usage remains constant during development in fetal piglets and postnatally in piglets exposed to environmental antigen - (Peer Reviewed Journal)

Butler, J.E., Sun, X., Wertz, N., Lager, K.M., Chaloner, L., Urban Jr., J., Francis, D.L., Nara, P.L., Tobin, G.J. 2011. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Molecular Immunology. 49(3):483-494.

DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs - (Peer Reviewed Journal)

Gorres, J.P., Lager, K.M., Kong, W.P., Royals, M., Todd, J.P., Vincent, A.L., Wei, C.J., Loving, C.L., Zanella, E.L., Janke, B., Kehrli, Jr., M.E., Nabel, G.J., Rao, S.S. 2011. DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs. Clinical and Vaccine Immunology. 18(11):1987-1995.

Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses - (Abstract Only)

Henningson, J.N., Faaberg, K.S., Guo, B., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Vorwald, A.C., Lager, K.M. 2011. Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses [abstract]. American College of Veterinary Pathologists. Paper No. 164. Veterinary Pathology. 48(6):E30.

Large scale parallel pyrosequencing technology: PRRSV strain VR-2332 nsp2 deletion mutant stability in swine - (Peer Reviewed Journal)

Guo, B., Vorwald, A.C., Alt, D.P., Lager, K.M., Bayles, D.O., Faaberg, K.S. 2011. Large scale parallel pyrosequencing technology: PRRSV strain VR-2332 nsp2 deletion mutant stability in swine. Virus Research. 161(2):162-169.

Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2 - (Peer Reviewed Journal)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Cheung, A.K., Butler, J.E., Kehrli, Jr., M.E. 2011. Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2. Veterinary Microbiology. 154(1-2):185-190.

Antigenic map of hemagglutinin (H) 1 proteins of 2010-2011 swine influenza viruses (SIV) in the U.S. swine population - (Abstract Only) - (07-Jun-11)

A live-attenuated chimeric PCV2 vaccine based on subtype 2b is transmitted to contact pigs but is not upregulated by concurrent infection with PPV and PRRSV and is efficacious in a triple challenge co-infection model - (Peer Reviewed Journal)

Opriessnig, T., Shen, H.G, Pal, N., Ramamoorthy, S., Huang, Y.W., Lager, K.M., Beach, N.M., Halbur, P.G., Meng, X.J. 2011. A live-attenuated chimeric porcine circovirus type 2 (PCV2) vaccine is transmitted to contact pigs but is not upregulated by concurrent infection with porcine parvovirus (PPV) and porcine reproductive and respiratory syndrome virus (PRRSV) and is efficacious in a PCV2b-PRRSV-PPV challenge model. Clinical and Vaccine Immunology. 18(8):1261-1268.

Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b - (Peer Reviewed Journal)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2011. Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b. Veterinary Microbiology. 153(3-4):229-239.

Immune transcriptome response to PRRSV infection - (Abstract Only)

Miller, L.C., Harhay, G.P., Lager, K.M., Kehrli, Jr., M.E. 2011. Immune transcriptome response to PRRSV infection [abstract]. XIIth International Nidovirus Symposium. p. 79.

Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo - (Abstract Only)

Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo [abstract]. XIIth International Nidovirus Symposium. p. 80.

Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs - (Peer Reviewed Journal)

Platt, R., Vincent, A.L., Gauger, P.C., Loving, C.L., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E., Kimura, K., Roth, J.A. 2011. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Veterinary Immunology and Immunopathology. 142(3-4):252-257.

Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine - (Abstract Only)

Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine [abstract]. 30th Annual Meeting of the American Society for Virology. p. 211.

HP-PRRSV challenge of 4 and 10-week-old pigs - (Proceedings)

Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Loving, C.L., Nicholson, T.L., Yang, H.C. 2011. HP-PRRSV challenge of 4 and 10-week-old pigs. In: Proceedings of the 5th Asian PRRSpective Symposium, May 10, 2011, Bangkok, Thailand. 6 pages.

Influenza A virus in swine - moving beyond 2009 - (Proceedings)

Vincent, A.L., Lorusso, A., Lager, K.M., Gauger, P.C., Gramer, M.R., Ciacci-Zanella, J.R. 2011. Influenza A virus in swine - moving beyond 2009. In: Proceedings of the 6th International Symposium on Emerging and Re-emerging Pig Diseases, June 12-15, 2011, Barcelona, Spain. p. 35-37.

Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus - (Peer Reviewed Journal)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A. 2011. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine. 29(15):2712-2719.

Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates in Domestic Pigs - (Peer Reviewed Journal) - (06-Jan-11)

Analysis of Chinese PRRSV Type 2 strain in U.S. swine - (Abstract Only)

Faaberg, K.S., Guo, B., Lager, K.M., Brockmeier, S.L., Henningson, J.N., Schlink, S.N., Miller, L.C., Yang, H. 2011. Analysis of Chinese porcine reproductive and respiratory syndrome virus type 2 strain in United States swine [abstract]. ASM Conference on Viral Genome Replication. Poster No. 55A. p. 69.

Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008 - (Peer Reviewed Journal)

Lorusso, A., Vincent, A.L., Harland, M.L., Alt, D., Bayles, D.O., Swenson, S.L., Gramer, M.R., Russel, C.A., Smith, D.J., Lager, K.M., Lewis, N.S. 2011. Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008. Journal of General Virology. 92(Pt 4):919-930.

In depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Miller, L.C., Neill, J.D., Harhay, G.P., Lager, K.M., Laegreid, W.W., Kehrli, Jr., M.E. 2010. In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus. Advances in Virology. 2010:Article 864181. Available: http://downloads.hindawi.com/journals/av/2010/864181.pdf.

Pandemic H1N1 influenza: zoonoses are a two-way street - (Abstract Only) - (16-Nov-10)

Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models - (Peer Reviewed Journal)

Ma, W., Lager, K.M., Li, X., Janke, B.H., Mosier, D.A., Painter, L.E., Ulery, E.S., Ma, J., Lekcharoensuk, P., Webby, R.J., Richt, J.A. 2011. Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models. Virology. 410(1):1-6.

G-CSF Analogue Treatment Increases Peripheral Neutrophil Numbers in Pigs - a Potential Alternative for In-Feed Antibiotics - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Bayles, D.O., Greenlee, J.J., Lager, K.M., Kehrli, Jr., M.E. 2010. G-CSF analogue treatment increases peripheral neutrophil numbers in pigs - a potential alternative for in-feed antibiotics. Conference of Research Workers in Animal Diseases. Paper No. 140.

Singular PCV2a or PCV2b infection results in apoptosis of hepatocytes in clinically affected gnotobiotic pigs - (Peer Reviewed Journal)

Sinha, A., Schalk, S., Lager, K.M., Wang, C., Opriessnig, T. 2012. Singular PCV2a or PCV2b infection results in apoptosis of hepatocytes in clinically affected gnotobiotic pigs. Research in Veterinary Science. 92(1):151-156.

Analysis of Asian PRRSV Type 2 Strains - (Abstract Only)

Guo, B., Lager, K.M., Yang, H., Faaberg, K.S. 2010. Analysis of Asian PRRSV type 2 strains [abstract]. International PRRS Symposium, Chicago, IL. Paper No. 24.

Swine Influenza Virus: Emerging Understandings - (Proceedings)

Vincent, A.L., Lorusso, A., Lager, K.M., Gauger, P.C., Gramer, M.R., Ciacci-Zanella, J.R. 2010. Swine influenza virus: emerging understandings. In: Proceedings of 18th Annual Swine Disease Conference for Swine Practitioners, November 4-5, 2010, Ames, IA. p. 57-62.

Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs - (Abstract Only)

Platt, R., Gauger, P., Kimura, K., Roth, J., Vincent, A., Loving, C., Zanella, E., Lager, K., Kehrli, M. 2010. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 085P/85P.

Genetic and Antigenic Characterization of H1 Influenza Viruses from United States Swine Prior to the Emergence of the 2009 Pandemic H1N1 - (Abstract Only)

Lorusso, A., Vincent, A., Harland, M., Alt, D., Bayles, D., Swenson, S., Gramer, M., Russell, C., Smith, D., Lager, K., Lewis, N. 2010. Genetic and antigenic characterization of H1 Influenza Viruses from United States swine prior to the emergence of the 2009 pandemic H1N1 [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 194.

Analysis of Asian PRRSV Type 2 Strains - (Abstract Only)

Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Yang, H.C., Faaberg, K.S. 2010. Analysis of Asian PRRSV type 2 strains [abstract]. 45th US-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p. 8.

Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)

Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript expression analysis in tracheobronchial lymph nodes of pseudorabies virus infected pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 115P.

Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)

Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript expression analysis in tracheobronchial lymph nodes of pseudorabies virus infected pigs [abstract]. 45th Meeting of the United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health. p. 11.

Pathogenesis Studies of the 2009 Pandemic Influenza Virus and Pseudorabies Virus From Wild Pigs In Swine - (Proceedings)

Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Miller, L.C., Kehrli, Jr., M.E. 2010. Pathogenesis studies of the 2009 pandemic influenza virus and pseudorabies virus from wild pigs in swine. In: Proceedings of the Brazilian Society for Virology XXI Meeting, October 18-20, 2010, Gramado, Rio Grande do Sul, Brazil. p. 33-34.

In Vivo Growth of Porcine Reproductive and Respiratory Syndrome Virus Engineered Nsp2 Deletion Mutants - (Peer Reviewed Journal)

Faaberg, K.S., Kehrli, Jr., M.E., Lager, K.M., Guo, B., Han, J. 2010. In vivo growth of porcine reproductive and respiratory syndrome virus engineered Nsp2 deletion mutants. Virus Research. 154(1-2):77-85.

Enhanced Pneumonia and Proinflammatory Cytokine Response in Pigs Challenged with Pandemic 2009 A/H1N1 Influenza Virus Following Vaccination with an Inactivated delta-Cluster H1N2 Virus - (Abstract Only)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.A., Roth, J.A. 2010. Enhanced pneumonia and proinflammatory cytokine response in pigs challenged with pandemic 2009 A/H1N1 influenza virus following vaccination with an inactivated delta-cluster H1N2 virus [abstract]. International Conference on Emerging Infectious Diseases. Paper No. L1345.

Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs - (Abstract Only)

Miller, L.C., Harhay, G.P., Bayles, D.O., Zanella, E.L., Lager, K.M. 2010. Transcript Expression Analysis in Tracheobronchial Lymph Nodes of Pseudorabies Virus Infected Pigs [abstract]. 32nd Conference for the International Society for Animal Genetics. Paper No. P105.

Viral Reassortment and Transmission after Coinfection of Pigs with Classical H1N1 and Triple Reassortant H3N2 Swine Influenza Viruses - (Peer Reviewed Journal)

Ma, W., Lager, K.M., Lekcharoensuk, P., Ulery, E.S., Janke, B.H., Solorzano, A., Webby, R.J., Garcia-Sastre, A., Richt, J.A. 2010. Viral reassortment and transmission after coinfection of pigs with classical H1N1 and triple reassortant H3N2 swine influenza viruses. Journal of General Virology. 91(Pt 9):2314-2321.

Development and validation of a real-time RT-PCR assay for the 2009 pandemic H1N1 virus in veterinary specimens - (Abstract Only)

Spackman, E., Suarez, D.L., Killian, M.L., Koster, L., Swenson, S., Pedersen, J., Vincent, A.L., Lager, K.M., Jenkins-Moore, M., Schmitt, B. 2010. Development and validation of a real-time RT-PCR assay for the 2009 pandemic H1N1 virus in veterinary specimens [abstract]. Swine Origin H1N1: The First Pandemic of the 21st Century meeting, April 18-20, 2010, Atlanta, Georgia. p. 30.

Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate - (Abstract Only)

Buehler, J., Mccullough, D., Loving, C.L., Vincent, A.L., Lager, K.M., Miller, C. 2010. Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate [abstract]. American Society for Virology Meeting. p. 279.

Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses - (Proceedings)

Lager, K.M., Vincent, A.L., Gauger, P.C., Senne, D.A., Swayne, D.E., Miller, L.C., Richt, J., Ma, W., Suarez, D.L., Kehrli Jr, M.E. 2010. Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 79.

Singular PCV2a or PCV2b Infection Results in Apoptosis of Hepatocytes in Clinically Affected Gnotobiotic Pigs - (Proceedings)

Sinha, A., Lager, K.M., Wang, C., Opriessnig, T. 2010. Singular PCV2a or PCV2b Infection Results in Apoptosis of Hepatocytes in Clinically Affected Gnotobiotic Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 55.

Challenge of Pigs with Natural Immunity to H1 and H3 Swine Influenza Virus with Pandemic 2009 H1N1 Influenza Virus - (Proceedings)

Ciacci Zanella, J.R., Lager, K.M., Vincent, A.L., Zanella, E.L., Gava, D. 2010. Challenge of Pigs with Natural Immunity to H1 and H3 Swine Influenza Virus with Pandemic 2009 H1N1 Influenza Virus. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 253.

Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates - (Proceedings)

Zanella, E.L., Lager, K.M., Miller, L.C., Swenson, S.L., Bigelow, T.T., Kehrli, Jr., M.E. 2010. Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 875.

Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs - (Proceedings)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M. 2010. Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 255.

Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2 - (Proceedings)

Kehrli, Jr., M.E., Gauger, P.C., Cheung, A.K., Vincent, A.L., Lager, K.M. 2010. Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 332.

Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs - (Proceedings)

Vincent, A.L., Ciacci Zanella, J.R., Lorusso, A., Zanella, E.L., Lager, K.M., Gauger, P.C., Janke, B.H., Kehrli, Jr., M.E. 2010. Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 74.

Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs - (Proceedings)

Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.R., Kehrli, Jr., M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 299.

Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States - (Proceedings)

Vincent, A.L., Harland, M.L., Lorusso, A., Alt, D.P., Bayles, D.O., Swenson, S.L., Gramer, M.R., Lager, K.M., Lewis, N. 2010. Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 259.

In Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus - (Abstract Only)

Miller, L.C., Harhay, G.P., Lager, K.M., Neill, J.D., Kehrli, Jr., M.E. 2010. In-Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus [abstract]. In: Proceedings of the 9th International Positive Strand RNA Virus Symposium, May 17-21, 2010, Atlanta, Georgia. p. 54.

Cytokine Protein Expression Levels in Tracheobronchial Lymph Node Homogenates of Pigs Infected with Pseudorabies Virus - (Peer Reviewed Journal)

Miller, L.C., Zanella, E.L., Waters, W.R., Lager, K.M. 2010. Cytokine Protein Expression Levels in Tracheobronchial Lymph Node Homogenates of Pigs Infected with Pseudorabies Virus. Clinical and Vaccine Immunology. 17(5):728-734.

Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs - (Peer Reviewed Journal)

Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.L., Kehrli Jr, M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs. Vaccine 28(15):2782-2787.

Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs - (Proceedings)

Vincent, A.L., Lager, K.M., Harland, M.L., Lorusso, A., Ciacci-Zanella, J.R., Zanella, E.L., Kehrli, Jr., M.E., Gauger, P.C., Janke, B.H., Klimov, A. 2010. Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs. In: Proceedings of the 41st Annual Meeting of the American Association of Swine Veterinarians, March 6-9, 2010, Omaha, Nebraska. p. 495-497.

Summary of Control Issues for Swine Influenza - (Abstract Only)

Vincent, A.L., Lager, K.M., Richt, J.A., Ma, W., Janke, B.H. 2010. Summary of control issues for swine influenza [abstract]. International Symposium on Neglected Influenza Viruses. p. 22.

Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Faaberg, K.S., Harland, M., Zanella, E.L., Zanella, J.R., Kehrli, Jr., M.E., Janke, B.H., Klimov, A. 2009. Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera. Influenza and Other Respiratory Viruses. 4(2):53-60.

Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Harland, M., Lorusso, A., Zanella, E., Ciacci-Zanella, J.R., Kehrli, Jr., M.E., Klimov, A. 2009. Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork. PLoS ONE. 4:(12):e8367.

Large-Scale Parallel Pyrosequencing Technology Reveals PRRSV VR-2332 Nsp2 Deletion Mutants Stable in Swine - (Abstract Only)

Guo, B., Faaberg, K.S., Lager, K.M., Kehrli, Jr., M.E. 2009. Large-Scale parallel pyrosequencing technology reveals PRRSV VR-2332 Nsp2 deletion mutants stable in swine [abstract]. International PRRS Symposium, Chicago, IL. Paper No. 34.

Swine Influenza Update - (Proceedings)

Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Lorusso, A., Faaberg, K.S., Kehrli, Jr., M.E. 2009. Swine influenza update. In: Proceedings of the 17th Annual Swine Disease Conference, November 5-6, 2009, Iowa State University, Ames, Iowa. pp. 128-131.

Identification and Characterization of a Highly Virulent Triple Reassortant H1N1 Swine Influenza Virus in the Midwest of the United States - (Peer Reviewed Journal)

Ma, W., Vincent, A.L., Lager, K.M., Janke, B.H., Henry, S.C., Rowland, R.R., Hesse, R.A., Richt, J.A. 2010. Identification and Characterization of a Highly Virulent Triple Reassortant H1N1 Swine Influenza Virus in the United States. Virus Genes. 40(1):28-36.

Cytokine Expression in the Tracheobronchial Lymph Nodes of Pigs Infected with Pseudorabies Virus - (Abstract Only)

Miller, L.C., Zanella, E.L., Waters, W.R., Lager, K.M. 2010. Cytokine protein expression levels in tracheobronchial lymph node homogenates of pigs infected with pseudorabies virus [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 71P.

Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Gramer, M.R., Richt, J.A., Janke, B.H. 2009. Characterization of a Newly Emerged Genetic Cluster of H1N1 and H1N2 Swine Influenza Virus in the U.S. Virus Genes. 39(2):176-185.

Genetic stability of PRRSV VR-2332 nsp2 deletion mutants in swine - (Abstract Only)

Guo, B., Faaberg, K.S., Lager, K.M., Kehrli, Jr., M.E. 2009. Genetic stability of PRRSV VR-2332 nsp2 deletion mutants in swine [abstract]. 28th Annual Meeting of the American Society for Virology, Vancouver, Canada. Paper No. W33-12.

Experimental Infection of Pigs with the 1918 Pandemic Influenza Virus - (Peer Reviewed Journal)

Weingartl, H.M., Albrecht, R.A., Lager, K.M., Babiuk, S., Marszal, P., Neufeld, J., Embury-Hyatt, C., Lekcharoensuk, P., Tumpey, T.M., Garcia-Sastre, A., Richt, J.A. 2009. Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus. Journal of Virology. 83(9):4287-4296.

Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus - (Peer Reviewed Journal)

Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.

Effect of porcine reproductive and respiratory syndrome virus infection of porcine alveolar macrophages on Toll-like receptors elicitation of type I interferon responses - (Peer Reviewed Journal)

Miller, L.C., Lager, K.M., Kehrli, Jr., M.E. 2009. Role of Toll-Like Receptors in Activation of Porcine Alveolar Macrophages by Porcine Reproductive and Respiratory Syndrome Virus. Clinical and Vaccine Immunology. 16(3):360-365.

Characterization of an Influenza A Virus Isolated from Pigs During an Outbreak of Respiratory Disease in Swine and People at a County Fair in the United States - (Peer Reviewed Journal)

Vincent, A.L., Swenson, S.L., Lager, K.M., Gauger, P.C., Loiacono, C., Zhang, Y. 2009. Characterization of an Influenza A Virus Isolated from Pigs During an Outbreak of Respiratory Disease in Swine and People at a County Fair in the United States. Veterinary Microbiology. 137(1-2):51-59.

Development of a replication defective adenovirus 5 vector expressing porcine interleukin-18 and a mutated analog - (Abstract Only)

Kappes, M.A., Ma, W., Richt, J.A., Lager, K.M., Vincent, A.L., Roth, J.A., Murtaugh, M.P., Kehrli, Jr., M.E. 2008. Development of a Replication Defective Adenovirus 5 Vector Expressing Porcine Interleukin-18 and a Mutated Analog [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 99P. p. 121.

The role of swine in the generation of novel influenza viruses - (Peer Reviewed Journal)

Ma, W., Lager, K.M., Vincent, A.L., Janke, B.H., Gramer, M.R., Richt, J.A. 2009. The Role of Swine in the Generation of Novel Influenza Viruses. Zoonoses and Public Health. 56(6-7):326-337.

Differential roles of Toll-like receptors in the elicitation of type I interferon responses by alveolar macrophages - (Abstract Only)

Miller, L.C., Chitko-Mckown, C.G., Lager, K.M., Kehrli, Jr., M.E. 2008. Differential Roles of Toll-Like Receptors in the Elicitation of Type I Interferon Responses by Alveolar Macrophages [abstract]. International PRRS Symposium. p. 58.

Effects of PRRSV infection on TLR-dependent induction of NOS - (Abstract Only)

Chitko McKown, C.G., Miller, L.C., Lager, K.M., Kehrli Jr, M.E. 2008. Effects of PRRSV infection on TLR-dependent induction of NOS (abstract). Proceedings of the 89th Conference of Research Workers in Animal Health. Poster No. 104P. p. 122.

PRRSV strain VR-2332 Nsp2 deletion mutants attenuate clinical symptoms in swine - (Abstract Only)

Faaberg, K.S., Han, J., Guo, B., Lager, K.M., Kehrli, Jr., M.E. 2008. PRRSV Strain VR-2332 NSP2 Deletion Mutants Attenuate Clinical Symptoms in Swine [abstract]. International PRRS Symposium. p. 55.

Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.

PRRSV strain VR-2332 Nsp2 deletion mutants attenuate clinical symptoms in swine - (Abstract Only)

Faaberg, K.S., Han, J., Lager, K.M., Kehrli, Jr., M.E., Rutherford, M.S. 2008. PRRSV Strain VR-2332 Nsp2 Deletion Mutants Attenuate Clinical Symptoms in Swine [abstract]. XIth International Symposium on Nidoviruses. Paper No. P63. p. 70.

Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses - (Peer Reviewed Journal)

Lipatov, A.S., Kwon, Y., Sarmento, L., Lager, K.M., Spackman, E., Suarez, D.L., Swayne, D.E. 2008. Domestic pigs have low susceptibility to H5N1 highly pathogenic avian influenza viruses. Public Library of Science for Pathogens [serial online]. 4(7):e1000102. Available: http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1000102.

Experimental Evaluation of a Swine Influenza Virus Isolated from a County Fair Outbreak in the United States - (Proceedings)

Vincent, A.L., Swenson, S.L., Lager, K.M., Gauger, P.C., Loiacono, C.M., Beach, T., Landgraf, J., Zhang, Y. 2008. Experimental Evaluation of a Swine Influenza Virus Isolated from a County Fair Outbreak in the United States. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. p. 7.

Pathogenesis of PCV2a and PCV2b virus in germ-free pigs - (Proceedings)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2008. Pathogenesis of PCV2a and PCV2b Virus in Germ-Free pigs. In: Proceedings of the International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. Paper No. OR.01.28.

Experimental infection of pigs with the 1918 pandemic influenza resembles infection with the classical H1N1 swine influenza - (Proceedings)

Weingartl, H.M., Albrecht, R.A., Lager, K.M., Babiuk, S., Marszal, P., Neufeld, J., Embury-Hyatt, C., Garcia-Sastre, A., Richt, J.A. 2008. Experimental Infection of Pigs with the 1918 Pandemic Influenza Resembles Infection with the Classical H1N1 Swine Influenza. In: Proceedings of the International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. Paper No. P01.021.

In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus - (Abstract Only)

Miller, L., Harhay, G., Lager, K., Kehrli Jr., M., Laegreid, W., Neill, J. 2008. In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus [abstract]. ARK-Genomics Conference 2008: 3rd International Symposium on Animal Functional Genomics. Paper No. ISAFG-P22. p. 38.

Swine Influenza Viruses: a North American Perspective - (Review Article)

Vincent, A.L., Ma, W., Lager, K.M., Janke, B.H., Richt, J.A. 2008. Swine Influenza Viruses: a North American Perspective. Advances in Virus Research. 72:127:154.

PIGLET MODELS IN STUDIES ON ANTIBODY REPERTOIRE DEVELOPMENT - (Peer Reviewed Journal)

Butler, J.E., Lager, K.M., Splichal, I., Francis, D., Kacskovics, I., Sinkora, M., Wertz, N., Sun, J., Zhao, Y., Brown, W.R., Dewald, R., Dierks, S., Muyldermanns, S., Lunney, J.K., Mccray, P.B., Rogers, C.S., Welsh, M.J., Navarro, P., Klobasa, F., Habe, F., Ramsoondar, J. 2009. Piglet models in studies on antibody repertoire development. Veterinary Immunology and Immunopathology. 128:147-170.

Development of realtime PCR for rapid detection and differentiation of field pseudorabies and vaccine viruses - (Peer Reviewed Journal)

Ma, W., Lager, K.M., Richt, J.,A. Stoffregen, W.C., Zhou, F., Janke, B.H., Yoon, K.J.. 2008. Development of real-time polymerase chain reaction assays for rapid detection and differentiation of wild-type pseudorabies and gene-deleted vaccine viruses. Journal of Veterinary Diagnostic Investigation. 20(4):440-447.

Porcine Reproductive and Respiratory Syndrome - (Book / Chapter)

Ludemann, L.R., Lager, K.M. 2008. Porcine Reproductive and Respiratory Syndrome. In: OIE Biological Standards Commission, editor. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2008: Mammals, Birds and Bees. 6th edition. Paris: Office International Des Epizooties. Volume 2. Chapter 2.8.7. p. 1116-1127.

Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) - (Peer Reviewed Journal)

Miller, L.C., Harhay, G.P., Lager, K.M., Smith, T.P., Neill, J.D. 2008. Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE). Developments in Biologicals. 132:169-174.

Porcine reproductive and respiratory syndrome virus (PRRSV) subverts normal development of adaptive immunity by proliferation of germline-encoded B cells with hydrophobic HCDR3 - (Peer Reviewed Journal)

Butler, J.E., Wertz, N., Weber, P., Lager, K.M. 2008. Porcine reproductive and respiratory syndrome virus subverts repertoire development by proliferation of germline-encoded B Cells of all isotypes bearing hydrophobic heavy chain CDR3. Journal of Immunology. 180(4):2347-2356.

Gene Expression Profiling of Porcine Reproductive and Respiratory Syndrome Virus Infected Porcine Alveolar Macrophages - (Abstract Only)

Miller, L.C., Harhay, G.P., Lager, K.M., Smith, T.P., Neill, J.D. 2007. Gene expression profiling of PRRSV-infected porcine alveolar macrophages [abstract]. Porcine Reproductive and Respiratory Syndrome International Symposium. Paper No. 47.

Viral Reassortment and Transmission after Coinfection of Pigs with two Swine Influenza Viruses - (Abstract Only)

Ma, W., Lager, K.M., Fleckenstein, E.S., Lekcharoensuk, P., Janke, B.H., Vincent, A.L., Webby, R.J., Richt, J.A. 2007. Viral reassortment and transmission after coinfection of pigs with 2 swine influenza viruses [abstract]. Conference of Research Workers in Animal Diseases Annual Meeting. Paper No. 146. p. 147.

Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Janke, B.H., Webby, R.J., Garcia-Sastre, A., Richt, J.A. 2007. Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine. 25:7999-8009.

VIRUS VACCINE RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER: LESSONS FROM SWINE INFLUENZA VIRUS AND BOVINE VIRAL DIARRHEA VIRUS - (Abstract Only)

Kehrli, Jr., M.E., Vincent, A.L., Richt, J.A., Wesley, R.D., Lager, K.M., Ridpath, J.F., Kimura, K., Roth, J.A. 2007. Virus vaccine research at the National Animal Disease Center: lessons from swine influenza virus and bovine viral diarrhea virus [abstract]. The Changing Landscape of Vaccine Development: Vaccines for Global Health. The University of Texas Medical Branch, Sealy Center for Vaccine Development. p. 14

Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate - (Proceedings)

Cheung, A.K., Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E. 2007. Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate. In: Proceedings of the 13th International World Association of Veterinary Laboratory Diagnosticians Symposium, November 11-14, 2007, Melbourne, Australia. p. 213.

Isolation of reassortant H2N3 avian/swine influenza virus from pigs in the United States - (Abstract Only)

Gramer, M., Goyal, S., Patnayak, D., Lager, K., Ma, W., Vincent, A., Richt, J., Webby, R. 2007. Isolation of reassortant H2N3 avian/swine influenza virus from pigs in the United States [abstract]. American Association of Veterinary Laboratory Diagnosticians 50th Annual Conference. p. 122.

Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Janke, B.H., Gramer, M.R., Richt, J.R. 2008. Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine. Veterinary Microbiology. 126(4):310-323.

Pathogenesis of avian influenza A (H5N1) viruses in pigs - (Abstract Only)

Lipatov, A.S., Kwon, Y., Lager, K.M., Suarez, D.L., Swayne, D.E. 2007. Pathogenesis of avian influenza A (H5N1) viruses in pigs [abstract]. In: Proceedings of the Research Conference on Orthomyxoviruses, September 21-24, 2007, Woods Hole, Massachusetts. p. 26.

Comparison of the pathogenicity of porcine circovirus type 2 group 1 and group 2 isolates - (Proceedings)

Cheung, A.K., Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T. 2007. Comparison of the pathogenicity of porcine circovirus type 2 group 1 and group 2 isolates. In: Proceedings of the 5th International Symposium on Emerging and Re-Emerging Pig Diseases, June 24-27, 2007, Krakow, Poland. p. 273.

Mortality in pigs given PCV2 virus derived from DNA clones - (Peer Reviewed Journal)

Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2007. Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Veterinary Record. 161(12):428-429.

Characterization of the leukogram in PCV2 infected germ-free pigs - (Proceedings)

Gauger, P.C., Lager, K.M., Cheung, A.K. 2007. Characterization of the leukogram in PCV2 infected germ-free pigs. In: Proceedings of the 46th Annual North Central Conference of Veterinary Laboratory Diagnosticians, June 7-8, 2007, Ames, Iowa. p. 39-42.

Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) - (Abstract Only)

Neill, J.D., Miller, L.C., Harhay, G.P., Lager, K.M. 2007. Effect of porcine reproductive and respiratory syndrome virus on porcine alveolar macrophage function as determined using serial analysis of gene expression (SAGE) [abstract]. International Symposium on Animal Genomics for Animal Health. Paper No. PA-070. p. 58.

Antibody repertoire development in fetal and neonatal piglets. XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome - (Peer Reviewed Journal)

Butler, J.E., Lemke, C.D., Weber, P., Sinkora, M., Lager, K.M. 2007. Antibody repertoire development in fetal and neonatal piglets. XIX. Undiversified B cells with hydrophobic HCDR3s preferentially proliferate in the porcine reproductive and respiratory syndrome. Journal of Immunology. 178(10):6320-6331.

PCVAD diagnosis and emerging diseases: building a systematic approach - (Proceedings)

Lager, K.M., Gauger, P.C., Vincent, A.L., Cheung, A.K. 2007. PCVAD diagnosis and emerging diseases: building a systematic approach. In: Proceedings of the American Association of Swine Veterinarians Annual Meeting, March 3-6, 2007, Orlando, Florida. p. 525-528.

Identification of two genotype subgroups of porcine circovirus type 2 in swine herds of the United States - (Abstract Only)

Cheung, A.K., Lager, K.M., Vincent, A.L. 2006. Identification of two genotype subgroups of porcine circovirus type 2 in swine herds of the United States [abstract]. Conference of Research Workers in Animal Diseases 87th Annual Meeting. Paper No. 171. p. 78.

The role of avian/human-like influenza polymerase genes in the adaptation of influenza viruses to pigs - (Abstract Only)

Ma, W., Lekcharoensuk, P., Lager, K.M., Webby, R., Yoon, K., Janke, B.H., Richt, J.A. 2006. The role of avian/human-like influenza polymerase genes in the adaptation of influenza viruses to pigs [abstract]. Conference of Research Workers in Animal Diseases 87th Annual Meeting. Paper No. 180. p. 163.

The selected B cell population in PRRS has a naive phenotype, undiversified repertoire and unusually hydrophobic HCDR3 - (Abstract Only)

Butler, J.E., Weber, P., Lemke, C.D., Kimura, K., Sinkora, M., Vincent, A.L., Vorwald, A.C., Lager, K.M. 2006. The selected B cell population in PRRS has a naive phenotype, undiversified repertoire and unusually hydrophobic HCDR3 [abstract]. 2006 International PRRS Symposium. Paper No. 33.

Detection of two porcine circovirus type 2 genotypic groups in United States swine herds - (Peer Reviewed Journal)

Cheung, A.K., Lager, K.M., Kohutyuk, O.I., Vincent, A.L., Henry, S.C., Baker, R.B., Rowland, R.R., Dunham, A.G. 2007. Detection of two porcine circovirus type 2 genotypic groups in United States swine herds. Archives of Virology. 152(5):1035-1044.

Diagnostics of Severe PCVAD - (Proceedings)

Lager, K.M., Vincent, A.L., Cheung, A.K., Gauger, P.C. 2006. Diagnostics of severe PCVAD. In: Proceedings of the 14th Annual Swine Disease conference for Practitioners, November 9-10, 2006, Ames, Iowa. p. 131-133.

Analysis of activated immune cell populations in the bronchoalveolar lavage fluid of pigs immunized and/or infected with SIV - (Abstract Only)

Kimura, K., Vincent, A.L., Richt, J.A., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Effect of vaccination and/or challenge of swine influenza virus on the proportion of activated cells in bronchoalveolar lavage fluid [abstract]. Great Lakes International Imaging and Flow Cytometry Association. Paper No. 7.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract Only)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceedings of the 87th Conference of Research Workers in Animal Diseases, December 3-5, 2006. Chicago, Illinois. p.124.

Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus - (Abstract Only)

Brockmeier, S.L., Lager, K.M., Grubman, M.J., Brough, D., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Lehmkuhl, H.D. 2006. Presence of interferon-alpha delays viral replication and reduces disease signs in pigs challenged with porcine reproductive and respiratory syndrome virus. Proceeding of the International PRRS Symposium, December 1-2, 2006, Chicago, Illinois. p. 27.

Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine - (Peer Reviewed Journal)

Richt, J.A, Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Loiacono, C.M., Janke, B.H., Wu, W.H., Yoon, K.J., Webby, R.J., Solorzano, A., Garcia-Sastre, A. 2006. Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. Journal of Virology. 80(22):11009-11018.

EVALUATION OF HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA VIRUSES FROM THE UNITED STATES - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Ma, W., Lekcharoensuk, P., Gramer, M.R., Loiacono, C., Richt, J.A. 2006. Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Veterinary Microbiology. 118(3-4):212-222.

OVERCOMING MATERNAL ANTIBODY INTERFERENCE BY VACCINATION WITH HUMAN ADENOVIRUS 5 RECOMBINANT VIRUSES EXPRESSING THE HEMAGGLUTININ AND THE NUCLEOPROTEIN OF SWINE INFLUENZA VIRUS - (Peer Reviewed Journal)

Wesley, R.D., Lager, K.M. 2006. Overcoming maternal antibody interference by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of swine influenza virus. Veterinary Microbiology. 118:67-75.

INFLUENZA VACCINE RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER - (Proceedings) - (30-Jun-06)

VACCINATION OF PIGS AGAINST SWINE INFLUENZA VIRUSES USING A NS1-DELETED MODIFIED LIVE VACCINE - (Abstract Only)

Richt, J.A., Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Ma, W., Loiacono, C.M., Wu, W.H., Webby, R.J., Solorzano, A., Garcia-Sastre, A. 2006. Vaccination of pigs against swine influenza viruses using a NS1-deleted modified live vaccine [abstract]. 13th International Conference on Negative Strand Viruses. Paper No. 277. p. 198.

ATTEMPTED TRANSMISSION OF SCRAPIE AND CWD TO SWINE: PRELIMINARY FINDINGS - (Proceedings)

Greenlee, J.J., Kunkle, R.A. Nicholson, E.M., Lager, K.M., Hamir, A.N. 2006. Attempted transmission of scrapie and CWD to swine: preliminary findings. 19th International Pig Veterinary Society Congress. p. 386.

THE ROLE OF AVIAN INFLUENZA POLYMERASE GENES IN THE ADAPTATION OF SWINE INFLUENZA VIRUS TO PIGS - (Abstract Only)

Ma, W., Lekcharoensuk, P., Lager, K.M., Webby, R., Yoon, K., Richt, J.A. 2006. The role of avian influenza polymerase genes in the adaptation of swine influenza virus to pigs [abstract]. American Society for Virology. Paper No. P30-5. p. 278-279.

FAILURE OF CROSS-PROTECTION BY INACTIVATED VACCINES FOR TWO U.S. H1 SWINE INFLUENZA VIRUS (SIV) ISOLATES - (Proceedings)

Vincent, A.L., Lager, K.M., Gramer, M.G., Richt, J.A., Janke, B.H. 2006. Failure of cross-protection by inactivated vaccines for two U.S. H1 swine influenza virus (SIV) isolates. In: Proceedings of the 19th International Pig Veterinary Society Congress, July 16-19, 2006, Copenhagen, Denmark. p. 266.

A FIELD-DEPLOYABLE FLUORESCENCE-BASED SENSOR EXCITED BY AN ORGANIC LIGHT EMITTING DEVICE FOR PRRSV DETECTION - (Abstract Only)

Tabatabai, L.B., Shinar, R., Shinar, J., Lager, K.M. 2006. A field-deployable fluorescence-based sensor excited by an organic light emitting device for PRRSV detection [abstract]. Stupka Memorial Symposium. Paper No. 14. p.13.

ASSAY FOR PROLIFERATION OF PORCINE PBMC WITH OREGON GREEN 488 AND ITS APPLICATION FOR EVALUATION OF T CELL RESPONSIVENESS TO SWINE INFLUENZA VIRUS - (Abstract Only)

Kimura, K., Vincent, A.L., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Assay for proliferation of porcine PBMC with Oregon Green 488 and its application for evaluation of T cell responsiveness to swine influenza virus [astract]. Journal of Immunology Supplement. 176:S118. Paper No. 59.12.

NOVEL SWINE INFLUENZA VIRUS SUBTYPE H3N1, UNITED STATES - (Peer Reviewed Journal)

Lekcharoensuk, P., Lager, K.M., Vemulapalli, R., Woodruff, M., Vincent, A.L., Richt, J.A. 2006. Novel swine influenza virus subtype H3N1, United States. Emerging Infectious Diseases. 12(5):787-794.

ACUTE BVDV INFECTIONS IN NON BOVINE SPECIES - (Abstract Only)

Ridpath, J.F., Lager, K.M., Vincent, A.L., Neill, J.D., Chase, C.L., Mark, C.S. 2006. Acute BVDV infections in non-bovine species. BVDV 2006 Symposium, National Cattlemens Beef Association Annual Meeting. Paper No. 19. p. 37.

INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS STIMULATES AN EARLY GAMMA INTERFERON RESPONSE IN THE SERUM OF PIGS - (Peer Reviewed Journal)

Wesley, R.D., Lager, K.M., Kehrli, Jr., M.E. 2006. Infection with porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs. Canadian Journal of Veterinary Research. 70(3):176-182.

EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Proceedings)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2005. Evaluation of North American hemagglutinin subtype 1 swine influenza isolates. 40th United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p. 7.

DEVELOPMENT OF A MULTIPLEX REAL-TIME PCR ASSAY FOR RAPID DETECTION AND DIFFERENTIATION OF PRV - (Abstract Only)

Ma, W., Lager, K., Richt, J., Yoon, K. 2005. Development of a multiplex real-time PCR assay for rapid detection and differentiation of PRV [abstract]. American Association of Veterinary Laboratory Diagnosticians 48th Annual Conference. p. 94.

ASSAY FOR PROLIFERATION OF PORCINE PBMC WITH OREGON GREEN 488 AND ITS APPLICATION FOR EVALUATION OF T CELL RESPONSIVENESS TO SWINE INFLUENZA VIRUS - (Abstract Only)

Kimura, K., Lager, K.M., Kehrli, Jr., M.E., Roth, J.A., Richt, J.A. 2005. Assay for proliferation of porcine PBMC with Oregon Green 488 and its application for evaluation of T cell responsiveness to swine influenza virus [abstract]. Great Lakes International Imaging and Flow Cytometry Association. Paper No. 10. p. 22.

SEROLOGIC AND PATHOGENIC EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Proceedings)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2006. Serologic and pathogenic evaluation of North American hemagglutinin subtype 1 swine influenza isolates. In: Proceedings of the American Association of Swine Veterinarians 2006 Annual Meeting, March 5-7, 2006, Kansas City, Missouri. p. 467-470.

EVALUATION OF A RECOMBINANT HUMAN ADENOVIRUS-5 VACCINE ADMINISTERED VIA NEEDLE-FREE DEVICE AND INTRAMUSCULAR INJECTION FOR VACCINATION OF PIGS AGAINST SWINE INFLUENZA VIRUS - (Peer Reviewed Journal)

Wesley, R.D., Lager, K.M. 2005. Evaluation of a recombinant human adenovirus-5 vaccine administered via needle-free device and intramuscular injection for vaccination of pigs against swine influenza virus. American Journal of Veterinary Research. 66(11):1943-1947.

ESTABLISHMENT OF A PIG MODEL FOR THE 1930 H1N1 SWINE INFLUENZA VIRUS AND APPLICATION OF REVERSE GENETICS - (Abstract Only)

Lekcharoensuk, P., Vincent, A.L., Lager, K.M., Solorzano, A., Garcia-Sastre, A., Richt, J.A. 2005. Establishment of a pig model for the 1930 H1N1 swine influenza virus and application of reverse genetics [abstract]. International Congress of Virology. p. 42.

EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Abstract Only)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2005. Evaluation of North American hemagglutinin subtype 1 swine influenza isolates [abstract]. International Congress of Virology. p. 44.

A MULTIPLEX FLUOROGENIC PCR ASSAY FOR RAPID DETECTION AND DIFFERENTIATION OF PSEUDORABIES VIRUS (AUJESZKY'S DISEASE VIRUS) - (Abstract Only)

Ma, W., Lager, K.M., Richt, J.A., Yoon, K. 2005. A multiplex fluorogenic PCR assay for rapid detection and differentiation of pseudorabies virus (Aujeszky's disease virus). Marker Vaccines and Differential Diagnostic Tests in Disease Control and Eradication, April 4-6, 2005, Ames, Iowa. p. 24.

MUTATIONS IN THE NS1 PROTEIN OF SWINE INFLUENZA VIRUS IMPAIRS ANTI-INTERFERON ACTIVITY AND CONFERS ATTENUATION IN PIGS - (Peer Reviewed Journal)

Solorzano, A., Webby, R.J., Lager, K.M., Janke, B.H., Garcia-Sastre, A., Richt, J.A. 2005. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. Journal of Virology. 79(12):7535-7543.

DETECTION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IN SEMEN AND SERUM OF BOARS DURING THE FIRST SIX DAYS AFTER INOCULATION - (Peer Reviewed Journal)

Reicks, D.L., Munoz-Zanzi, C., Mengeling, W., Christopher-Hennings, J., Lager, K., Polson, D., Dee, S., Rossow, K. 2006. Detection of porcine reproductive and respiratory syndrome virus in semen and serum of boars during the first six days after inoculation. Journal of Swine Health and Production. 14(1):35-41.

SWINE INFLUENZA: DIVERSITY OF U.S. VIRUS ISOLATES AND NOVEL VACCINE APPROACHES - (Proceedings)

Richt, J.A., Lager, K.M., Lekcharoensuk, P., Janke, B.H., Solorzano, A., Garcia-Sastre, A., Webby, R.J. 2004. Swine influenza: diversity of U.S. virus isolates and novel vaccine approaches. In: Proceedings of the Twelfth Annual Swine Disease Conference for Swine Practitioners, Iowa State University, November 11-12, 2004, Ames, Iowa. p. 40-44.

PRRSV INFECTION STIMULATES AN EARLY SERUM IFN-GAMMA RESPONSE IN PIGS - (Abstract Only)

Wesley, R.D., Lager, K.M., Kehrli Jr., M.E. 2004. PRRSV infection stimulates an early serum IFN-gamma response in pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. P89. p. 103.

GENOMIC CHARACTERIZATION AND LIBRARY OF INFECTIOUS GENOMES OF THE ATTENUATED NORTH AMERICAN STRAIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal)

Grebennikova, T.V., Zaberezhny, A.D., Musienko, M.I., Mengeling, W.L., Lager, K.M., Aliper, T.I., Nepoklonov, E.A. 2004. Genomic characterization and library of infectious genomes of the attenuated North American strain of porcine reproductive and respiratory syndrome virus (in Russian). Voprosy Virusologli (Rus). 3:56-63.

IDENTIFICATION OF SWINE INFLUENZA VIRUS VIRULENCE FACTORS USING REVERSE GENETICS: A NOVEL APPROACH TO VACCINE DEVELOPMENT - (Proceedings)

Solorzano, A., Webby, R.J., Lager, K.M., Janke, B.H., Richt, J. 2004. Identification of swine influenza virus virulence factors using reverse genetics: a novel approach to vaccine development. In: Proceedings of the 18th Congress of the International Pig Veterinary Society, June 27-July 2, 2004, Hamburg, Germany. p. 6.

TISSUE DISTRIBUTION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) IN FINISHER AGE BOARS AND GILTS AT VARIOUS TIMES POST INFECTION - (Proceedings)

Brockmeier, S., Lager, K.M. 2004. Tissue distribution of porcine reproductive and respiratory syndrome virus (prrsv) in finisher age boars and gilts at various times post infection. Pig Veterinary Society International Congress Proceedings. p. 51.

A RECOMBINANT AD5 SWINE INFLUENZA VACCINE THAT OVERRIDES MATERNAL ANTIBODY INTERFERENCE - (Proceedings)

Wesley, R.D., Lager, K.M. 2004. A recombinant Ad5 swine influenza vaccine that overrides maternal antibody interference. In: Proceedings of the 18th Congress of the International Pig Veterinary Society, Hamburg, Germany, June 27-July 2, 2004. p. 47.

THE NSI PROTEIN OF INFLUENZA A VIRUS IS A DETERMINANT OF VIRULENCE IN VIVO - (Abstract Only)

Solorzano, A., Webby, R.J., Lager, K.M., Richt, J.A., Garcia-Sastre, A. 2004. The NS1 protein of influenza a virus is a determinant of virulence in vivo. 23rd Annual Meeting of the American Society for Virology. Paper No. W34-3.

REAL-TIME RT-PCR ASSAYS FOR THE DETECTION AND DIFFERENTIATION OF NORTH AMERICAN SWINE INFLUENZA VIRUSES - (Peer Reviewed Journal)

Richt, J.A., Lager, K.M., Clouser, D.F., Spackman, E., Suarez, D.L., Yoon, K.-J. 2004. Real-time RT-PCR assays for the detection and differentiation of North American swine influenza viruses. Journal of Veterinary Diagnostic Investigation. 16:367-373.

PRRSV INFECTION STIMULATES AN IMMEDIATE SERUM INTERFERON-GAMMA RESPONSE - (Proceedings)

Wesley, R.D., Lager, K.M., Kehrli, Jr., M.E. 2004. PRRSV infection stimulates an immediate serum interferon-gamma response. In: Proceedings of the 18th Congress of the International Pig Veterinary Society (IPVS) Congress, June 27-July 2, 2004, Hamburg, Germany. p. 90.

PROTECTION OF WEANED PIGS BY VACCINATION WITH HUMAN ADENOVIRUS 5 RECOMBINANT VIRUSES EXPRESSING THE HEMAGGLUTININ AND THE NUCLEOPROTEIN OF H3N2 SWINE INFLUENZA VIRUS - (Peer Reviewed Journal)

Wesley, R.D., Lager, K.M., Tang, M. 2004. Protection of weaned pigs by vaccination with human adenovirus 5 recombinant viruses expressing the hemagglutinin and the nucleoprotein of H3N2 swine influenza virus. Vaccine. 22:3427-3434.

PRACTICAL ASPECTS OF PRRS CONTROL - (Proceedings)

Lager, K.M. 2004. Practical aspects of PRRS control. In: Proceedings of the 10th Annual Polish Pig Veterinary Conference, June 8-9, 2004, Pulawy, Poland, published in Polish in a supplemental edition 2004 of the Magazyn Weterynaryjny. p. 10-15.

GENOMIC CHARACTERIZATION OF VIRULENT, ATTENUATED, AND REVERTANT PASSAGES OF A NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS STRAIN - (Peer Reviewed Journal)

Grebennikova, T.V., Clouser, D.F., Vorwald, A.C., Musienko, M.I., Mengeling, W.L., Lager, K.M., Wesley, R.D., Biketov, S.F., Zaberezhny, A.D., Aliper, T.I., Nepoklonov, E.A. 2004. Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain. Virology. 321(2):383-390.

EFFECT OF PORCINE PARVOVIRUS VACCINATION ON THE DEVELOPMENT OF PMWS IN SEGREGATED EARLY WEANED PIGS COINFECTED WITH TYPE 2 PORCINE CIRCOVIRUS AND PORCINE PARVOVIRUS - (Peer Reviewed Journal)

Opriessnig, T., Fenaux, M., Yu, S., Evans, R.B., Cavanaugh, D., Gallup, J.M., Pallares, F.J., Thacker, E.L., Lager, K.M., Meng, X.J., Halbur, P.G. 2004. Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus. Veterinary Microbiology. 98(3-4):209-220.

LYMPHOID HYPERPLASIA RESULTING IN IMMUNE DYSREGULATION IS CAUSED BY PRRSV INFECTION IN NEONATAL PIGS - (Peer Reviewed Journal)

Lemke, C.D., Haynes, J.S., Spaete, R.J., Adolphson, D., Vorwald, A.C., Lager, K.M., Butler, J.E. 2004. Lymphoid hyperplasia resulting in immune dysregulation is caused by porcine reproductive and respiratory syndrome virus infection in neonatal pigs. Journal of Immunology. 172(3):1916-1925.

AN INFECTIOUS GENOMIC CDNA CLONE OF THE ATTENUATED PRRSV STRAIN OF NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Abstract Only)

Grebennikova, T.V., Zaberezhny, A.D., Musienko, M.I., Mengeling, W.L., Lager K.M., Aliper, T.I., Nepoklonov, E.A. 2003. An infectious genomic cDNA clone of the attenuated PRRSV strain of North American porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Animals Diseases. p. 108.

RAPID DETECTION OF SWINE VIRUSES USING REAL-TIME PCR ASSAYS - (Abstract Only)

RICHT, J., LAGER, K.M., SUAREZ, D.L., YOON, K.J. RAPID DETECTION OF SWINE VIRUSES USING REAL-TIME PCR ASSAYS. AMERICAN ASSOCIATION OF VETERINARY LABORATORY DIAGNOSTICIANS. 2003. ABSTRACT P. 150.

SWINE INFLUENZA VIRUSES IN THE UNITED STATES: ROLE OF AVIAN INFLUENZA VIRUS GENE PRODUCTS IN EMERGENCE OF NEW SWINE GENOTYPES - (Abstract Only)

Webby, R.J., Lager, K.M., Janke, B.H., Richt, J. 2003. Swine influenza viruses in the United States: role of avian influenza virus gene products in emergence of new swine genotypes. 4th International Conference on Emerging Zoonoses. p. 45.

A RECOMBINANT AD-5 SWINE INFLUENZA VACCINE THAT OVERRIDES MATERNAL ANTIBODY INTERFERENCE - (Proceedings)

Wesley, R.D., Lager, K.M. 2004. A recombinant Ad-5 swine influenza vaccine that overrides maternal antibody interference. Proceedings of the 35th Annual Meeting of the American Association of Swine Veterinarians, March 6-9, 2004, Des Moines, Iowa. p. 447-449.

SIV DIVERSITY: IMPLICATIONS FOR VACCINE EFFICACY - (Proceedings)

Richt, J., Lager, K.M., Janke, B.H., Webby, R.J. SIV diversity: implications for vaccine efficacy. 2003. In: Proceedings of the 11th Annual Swine Disease Conference for Swine Practitioners, November 6-7, 2003, Iowa State University, Ames, Iowa. P. 10-14.

SURVEY FOR SELECTED VIRAL DISEASES IN FERAL SWINE FROM SOUTH CAROLINA - (Abstract Only)

RICHT, J., STOFFREGEN, W.C., LAGER, K.M., WEBBY, R.J. SURVEY FOR SELECTED VIRAL DISEASES IN FERAL SWINE FROM SOUTH CAROLINA. DISEASES AT THE INTERFACE BETWEEN DOMESTIC LIVESTOCK AND WILDLIFE SPECIES. 2003. Abstract No. 16.

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME: CONTROL AND VACCINOLOGY - (Proceedings)

LAGER, K.M. PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME: CONTROL AND VACCINOLOGY. PROCEEDINGS OF INTERNATIONAL SYMPOSIUM ON EMERGING AND RE-EMERGING PIG DISEASES. 2003. p. 29-36.

ATTENUATION OF AN H3N2 SWINE INFLUENZA VIRUS UTILIZING A REVERSE GENETICS APPROACH - (Proceedings)

RICHT, J., LAGER, K.M., JANKE, B.H., GARCIA-SASTRE, A., WEBSTER, R., WEBBY, R.J. ATTENUATION OF AN H3N2 SWINE INFLUENZA VIRUS UTILIZING A REVERSE GENETICS APPROACH. PROCEEDINGS OF INTERNATIONAL SYMPOSIUM ON EMERGING AND RE-EMERGING PIG DISEASES. 2003. p. 264-265.

PATHOGENIC AND ANTIGENIC PROPERTIES OF PHYLOGENETICALLY DISTINCT REASSORTANT H3N2 SWINE INFLUENZA VIRUSES CO-CIRCULATING IN THE UNITED STATES - (Peer Reviewed Journal)

RICHT, J., LAGER, K.M., JANKE, B.H., WOODS, R.D., WEBSTER, R.G., WEBBY, R.J. PATHOGENIC AND ANTIGENIC PROPERTIES OF PHYLOGENETICALLY DISTINCT REASSORTANT H3N2 SWINE INFLUENZA VIRUSES CO-CIRCULATING IN THE UNITED STATES. JOURNAL OF CLINICAL MICROBIOLOGY. 2003. v. 41. p. 3198-3205.

INCREASED LITTER SURVIVAL RATES, REDUCED CLINICAL ILLNESS AND BETTER LACTOGENIC IMMUNITY AGAINST TGEV IN GILTS THAT WERE PRIMED AS NEONATES WITH PORCINE RESPIRATORY CORONAVIRUS (PRCV) - (Peer Reviewed Journal)

Wesley, R.D., Lager, K.M. Increased litter survival rates, reduced clinical illness and better lactogenic immunity against TGEV in gilts that were primed as neonates with porcine respiratory coronavirus (PRCV). Veterinary Microbiology. 95(3):175-186.

LYMPHOID HYPERPLASIA IN NEONATAL PIGLETS IS A RESULT OF PRRSV INFECTION - (Abstract Only)

BOHLKEN, C.D., HAYNES, J.S., SPAETE, R.J., ADOLPHSON, D., VORWALD, A.C., LAGER, K.M., BUTLER, J.E. LYMPHOID HYPERPLASIA IN NEONATAL PIGLETS IS A RESULT OF PRRSV INFECTION. AMERICAN ASSOCIATION FOR IMMUNOLOGY. 2003. ABSTRACT NO. 31.21. p. C20.

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (ILLINOIS SWINE HEALTH SEMINAR, SPRINGFIELD, ILL., DEC. 4, 2002) - (Proceedings) - (04-Dec-02)

STRAIN PREDOMINANCE FOLLOWING EXPOSURE OF VACCINATED AND NAIVE PREGNANT GILTS TO MULTIPLE STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal)

Lager, K.M., Mengeling, W.L., Wesley, R.D. 2003. Strain predominance following exposure of vaccinated and naive pregnant gilts to multiple strains of porcine reproductive and respiratory syndrome virus. Canadian Journal of Veterinary Research. 67:121-127.

ESTABLISHMENT OF A REAL-TIME PCR ASSAY FOR SWINE INFLUENZA VIRUSES - (Abstract Only) - (10-Nov-02)

COMPARATIVE SAFETY AND EFFICACY OF ATTENUATED SINGLE-STRAIN AND MULTI-STRAIN VACCINES FOR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Peer Reviewed Journal) - (15-Sep-02)

STRAIN SPECIFICITY AND EFFICACY OF THE IMMUNE RESPONSE OF PIGS FOLLOWING VACCINATION WITH VARIOUS STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (23-Aug-02)

H3N2 SWINE INFLUENZA VIRUSES: PATHOGENICITY OF DIFFERENT ANTIGENIC CLUSTERSAND THE APPLICATION OF SWINE INFLUENZA REVERSE GENETICS - (Abstract Only) - (27-Jul-02)

PROTECTIVE ROLE OF RECOMBINANT ADENOVIRAL VACCINE ENCODING THE HA GENE OF SWINE H3N2 VIRUS AGAINST HETEROLOGOUS VIRUS CHALLENGE - (Abstract Only) - (20-Jul-02)

A REVIEW OF AREA SPREAD AND SUMMARY OF RECENT STUDIES - (Proceedings)

LAGER, K.M., BROCKMEIER, S. A REVIEW OF AREA SPREAD AND SUMMARY OF RECENT STUDIES. PROCEEDINGS OF ALLEN D LEMAN SWINE CONFERENCE. 2002. p. 68-70.

EXPERIEMNTAL AIRBORNE TRANSMISSION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND BORDETELLA BRONCHISEPTICA - (Peer Reviewed Journal)

BROCKMEIER, S.L. LAGER, K.M. EXPERIEMNTAL AIRBORNE TRANSMISSION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND BORDETELLA BRONCHISEPTICA. VETERINARY MICROBIOLOGY. 2002. v. 89. p. 267-275.

EVALUATION OF IMMUNE RESPONSE INDUCED BY ATTENUATED AND WILD-TYPE PRRS VIRUS - (Proceedings) - (03-Jun-02)

PATHOGENICITY OF H3N2 SWINE INFLUENZA VIRUSES AND THE APPLICATION OF REVERSE GENETICS - (Proceedings) - (03-Jun-02)

RAPID DETECTION OF SWINE INFLUENZA VIRUSES USING A REAL-TIME PCR ASSAY - (Proceedings) - (03-Jun-02)

ACTUAL VIEW ON IMMUNOLOGY AND EPIDEMIOLOGY OF PRRS, PSEUDORABIES AND PMWS (IN: MAGAZYNY WETERYNARYJNY) - (Proceedings) - (11-Apr-02)

EFFECT OF FETAL PRRSV INFECTION ON THE DEVELOPMENT OF THE PORCINE IMMUNE SYSTEM - (Proceedings)

LAGER, K.M., BUTLER, J.E. EFFECT OF FETAL PRRSV INFECTION ON THE DEVELOPMENT OF THE PORCINE IMMUNE SYSTEM. PROCEEDINGS OF THE AMERICAN ASSOCIATION OF SWINE VETERINARIANS ANNUAL MEETING. 2002. p. 299-300.

MIDGESTATION FETAL PRRSV INFECTION DID NOT INDUCE AN IMMUNOTOLERANT STATE - (Proceedings) - (01-Mar-02)

INTERACTIONS AMONG PORCINE REPRODUCTIVE AND RESPIRATORY SYSTEM VIRUS (PRRSV), BRODETELLA BRONCHISEPTICA AND HAEMOPHILUS PARASUIS IN SWINE RESPIRATORY DISEASE - (Proceedings) - (01-Mar-02)

SWITCH RECOMBINATION IN FETAL PORCINE THYMUS IS UNCOUPLED FROM SOMATIC MUTATION - (Peer Reviewed Journal)

BUTLER, J.E., SUN, J., WEBER, P., FORD, S.P., REHAKOVA, Z., SINKORA, J., FRANCIS, D., LAGER, K.M. SWITCH RECOMBINATION IN FETAL PORCINE THYMUS IS UNCOUPLED FROM SOMATIC MUTATION. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY. 2002. v. 87. p. 307-319.

COMPARISON OF CELLULAR IMMUNE RESPONSE INDUCED BY ATTENUATED AND WILD-TYPE PRRS VIRUS - (Abstract Only) - (11-Nov-01)

IN VIVO AND IN VITRO STUDIES USING H3N2 SWINE INFLUENZA VIRUSES FROM THREE DISTINCT ANTIGENIC CLUSTERS - (Abstract Only) - (11-Nov-01)

COMPARISON OF CELLULAR IMMUNE RESPONSE INDUCED BY ATTENUATED AND WILD-TYPE PRRS VIRUS - (Abstract Only) - (12-Oct-01)

EVIDENCE FOR LOCAL SPREAD OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (16-Aug-01)

ANTIBODY REPERTOIRE DEVELOPMENT IN FETAL AND NEONATAL PIGLETS. IV. SWITCH RECOMBINATION, PRIMARILY IN FETAL THYMUS, OCCURS INDEPENDENT OF ENVIRONMENTAL ANTIGEN AND IS ONLY WEAKLY ASSOCIATED WITH REPERTOIRE - (Peer Reviewed Journal) - (16-Jul-01)

EVALUATION OF THE SENSITIVITY OF FETAL SEROLOGY, IHC, AND PCR FOR THE DIAGNOSIS OF PRRSV IN FETUSES - (Proceedings) - (21-Dec-00)

IN VITRO DETECTION OF SHIGA TOXIN USING PORCINE ALVEOLAR MACROPHAGES - (Peer Reviewed Journal) - (14-Dec-00)

GENETIC RECOMBINATION AMONG STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORYSYNDROME VIRUS - (Abstract Only) - (12-Nov-00)

THE USE OF PORCINE ALVEOLAR MACROPHAGES FOR DETECTING SHIGA TOXIN - (Abstract Only) - (01-Oct-00)

EFFECT OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) EXPOSURE DOSE ON FETAL INFECTION IN VACCINATED AND NONVACCINATED SWINE - (Peer Reviewed Journal) - (01-Jul-00)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME: VACCINES AND IMMUNITY - (Proceedings) - (06-Jun-00)

INTERACTIONS AMONG PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV), BORDETELLA BRONCHISEPTICA AND PASTEURELLA MULTOCIDA IN SWINE RESPIRATORY DISEASE (FOR INT. PIG. VET. SOC. CONGR., IN AUSTRALIA, 9/2000) - (Proceedings) - (06-Jun-00)

IMMUNOLOGY AND EPIDEMIOLOGY OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME, PSEUDORABIES, AND POSTWEANING MULTISYSTEMIC WASTING SYNDROME - (Proceedings) - (02-Jun-00)

THE ROLE OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND PSEUDORABIES VIRUS IN SWINE RESPIRATORY DISEASE - (Proceedings) - (02-Jun-00)

PRRS: NATURE OF THE RNA VIRUS AND HOW IT CAUSES DISEASE - (Proceedings) - (01-Jun-00)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) IN THE U.S.A. - (Proceedings) - (01-Jun-00)

THE EFFECT OF PORCINE PARVOVIRUS AND PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS ON PORCINE REPRODUCTIVE PERFORMANCE - (Peer Reviewed Journal) - (15-Mar-00)

EXPERIMENTAL AEROSOL TRANSMISSION OF PSEUDORABIES VIRUS AND PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (11-Mar-00)

A BRIEF REVIEW OF PROCEDURES AND POTENTIAL PROBLEMS ASSOCIATED WITH THE DIAGNOSIS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (27-Oct-99)

A SURVEY OF PRRSV DETECTION METHODS - (Proceedings) - (07-Oct-99)

EVIDENCE FOR AREA SPREAD OF PRRSV - (Proceedings) - (07-Oct-99)

PROGRESS TOWARD THE PREVENTION AND CONTROL OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (13-Jul-99)

DIAGNOSING ACUTE INFECTIONS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IN SWINE - (Proceedings) - (21-Jun-99)

DIAGNOSING ACUTE INFECTIONS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IN SWINE - (Proceedings) - (21-Jun-99)

A BRIEF REVIEW OF PROCEDURES AND POTENTIAL PROBLEMS ASSOCIATED WITH THE DIAGNOSIS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (21-Jun-99)

SAFETY AND EFFICACY OF VACCINATION OF PREGNANT GILTS AGAINST PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Peer Reviewed Journal) - (24-Mar-99)

SIGNIFICANCE OF PRRSV MUTATIONS ON THE FARM - (Proceedings) - (27-Feb-99)

EVALUATION OF PROTECTIVE IMMUNITY IN GILTS INOCULATED WITH THE NADC-8 ISOLATE OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) AND CHALLENGE-EXPOSED TO AN ANTIGENICALLY DISTINCT PRRSV ISOLATE - (Peer Reviewed Journal) - (09-Nov-98)

CLINICAL EFFECTS OF PRRSV MUTATIONS ON THE FARM PROCEEDINGS OF THE US-JAPAN COOPERATIVE PROGRAM IN NATURAL RESOURCES, NOVEMBER 4, 1998, NATL. VET. SERVICES LABS.,AMES, IOWA - (Proceedings) - (04-Nov-98)

DIAGNOSTIC IMPLICATIONS OF CONCURRENT INOCULATION WITH ATTENUATED AND VIRULENT STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (21-Oct-98)

PATHOGENESIS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS-INDUCED MATERNAL REPRODUCTIVE FAILURE - (Other) - (08-Aug-98)

CLINICAL CONSEQUENCES OF EXPOSING PREGNANT GILTS TO STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS ISOLATED FROM FIELD STRAINS OF "ATYPICAL" PRRS - (Peer Reviewed Journal) - (20-Jul-98)

EVALUATION OF THE PATHOGENICITY OF "ATYPICAL PRRS" VIRUS ISOLATES IN CAESAREAN-DERIVED-COLOSTRUM-DEPRIVED (CDCD) PIGS - (Proceedings) - (05-Jul-98)

IDENTIFICATION AND CLINICAL ASSESSMENT OF SUSPECTED VACCINE-RELATED FIELD STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (01-Jul-98)

EVIDENCE FOR DIVERGENCE OF RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP) PATTERNS FOLLOWING IN VIVO REPLICATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (29-Jun-98)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (JUNE 1 - JULY 2, 1998, HELD AT IOWA STATE UNIVERSITY) - (Proceedings) - (01-Jun-98)

HUMORAL IMMUNE RESPONSE IN SWINE TO LIVE AND INACTIVATED PRRSV VACCINES - (Proceedings) - (10-Mar-98)

ACUTE PRRS - (Proceedings) - (07-Mar-98)

EVIDENCE FOR THE DIVERGENCE OF RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP) PATTERNS AFTER REPLICATION OF PRRSV IN PIGS - (Proceedings) - (07-Mar-98)

EVALUATION OF THE PATHOGENIC EFFECTS OF AN "ATYPICAL PRRS" VIRUS ISOLATE IN PREGNANT GILTS - (Proceedings) - (01-Jan-98)

DIAGNOSTIC IMPLICATIONS OF DUAL INFECTION OF PIGS WITH ATTENUATED (VACCINE)AND VIRULENT STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (01-Jan-98)

EPIDEMIOLOGY AND CONTROL OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME IN THE UNITED STATES - (Proceedings) - (18-Dec-97)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS): DIAGNOSIS - (Book / Chapter) - (15-Dec-97)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS): LESIONS - (Book / Chapter) - (15-Dec-97)

DIFFERENTIATION OF A PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE STRAIN FROM NORTH AMERICAN FIELD STRAINS BY RESTRICTION FRAGMENT LENGTH POLYMORPHISM ANALYSIS OF ORF 5 - (Peer Reviewed Journal) - (30-Oct-97)

SEVERE ACUTE PRRS FROM A DIAGNOSTICIAN'S PERSPECTIVE 5TH SWINE DISEASE CONFERENCE FOR SWINE PRACTITIONERS, OCT. 30-31, 1997, IOWA STATE UNIVERSITY, AMES, IOWA - (Proceedings) - (30-Oct-97)

EFFECTS OF POOLED SAMPLES ON THE SENSITIVITY OF PRRSV ISOLATION - (Proceedings) - (17-Oct-97)

EPIZOOTIOLOGY, DIAGNOSIS, AND PROPHYLAXIS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (02-Oct-97)

EXPERIMENTAL REPRODUCTION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV)-ASSOCIATED HEPATIC DISEASE - (Abstract Only) - (30-Sep-97)

WHAT YOU NEED TO KNOW ABOUT PRRS - (Proceedings) - (18-Sep-97)

CLINICAL EFFECTS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS ON PIGS DURING THE EARLY POSTNATAL INTERVAL - (Peer Reviewed Journal) - (18-Aug-97)

VIRUS-INDUCED REPRODUCTIVE DISEASES OF SWINE - (Proceedings) - (04-Aug-97)

VIRUSES AS A CAUSE OF REPRODUCTIVE FAILURE IN PIGS (23RD SYMPOSIUM ON SWINE DISEASES, GDANSK, POLAND; JUNE 5, 1997[IN POLISH]) - (Proceedings) - (05-Jun-97)

VIRUSES AS A CAUSE OF REPRODUCTIVE FAILURE IN PIGS - (Proceedings) - (02-Jun-97)

AN UPDATE OF CURRENT RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER ON CURRENT FIELD STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS - (Proceedings) - (01-Jun-97)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (27-May-97)

DURATION OF HOMOLOGOUS PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IMMUNITY IN PREGNANT SWINE - (Peer Reviewed Journal) - (16-May-97)

HOMOLOGOUS CHALLENGE OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUSIMMUNITY IN PREGNANT SWINE - (Peer Reviewed Journal) - (16-May-97)

CONFIRMATION OF ANTIBODIES TO PRRSV BY RECOMBINANT ANTIGENS - (Abstract Only) - (15-May-97)

PRIOR INFECTION OF NURSERY-AGE PIGS WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS DOES NOT AFFECT THE OUTCOME OF TRANSMISSIBLE GASTROENTERITIS VIRUS CHALLENGE - (Abstract Only) - (20-Apr-97)

AN OVERVIEW OF THE ATYPICAL PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (01-Apr-97)

CURRENT STATUS OF VACCINES AND VACCINATION FOR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - (Proceedings) - (01-Mar-97)

PRRS: WHAT IS NEW? - (Proceedings) - (26-Jan-97)

SUCCESSFUL PSEUDORABIES VACCINATION IN MATERNALLY IMMUNE PIGLETS USING RECOMBINANT VACCINIA VIRUS VACCINES - (Peer Reviewed Journal) - (27-Nov-96)

EVALUATION OF PCR-RFLP AS A PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS DIFFERENTIAL TEST IN EXPERIMENTALLY INFECTED PIGS - (Abstract Only) - (12-Nov-96)

IDENTIFICATION OF DUAL INFECTION IN PIGLETS WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (18-Oct-96)

APPLICATION OF A TEST FOR DIFFERENTIATION OF STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY DIRECT EXAMINATION OF DIAGNOSTIC SAMPLES - (Proceedings) - (18-Oct-96)

DIFFERENTIATION OF RESPPRRS VACCINE FROM FIELD STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY RT-PCR AND RESTRICTION ENZYME ANALYSIS - (Proceedings) - (18-Oct-96)

AN OVERVIEW ON VACCINATION FOR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (24-Sep-96)

VIRUS-INDUCED REPRODUCTIVE DISEASES OF FARM ANIMALS - (Proceedings) - (21-Sep-96)

PATHOGENESIS OF FETAL PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS INFECTION DURING EARLY AND LATE GESTATION - (Proceedings) - (10-Jul-96)

ATTENUATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY SERIAL PASSAGE IN CELL CULTURE - (Proceedings) - (10-Jul-96)

HUMORAL AND CELL MEDIATED IMMUNE RESPONSE IN PIGS TO GLYCOPROTEINS GB, GC AND GD OF PSEUDORABIES VIRUS DELIVERED BY A VACCINIA VIRUS VECTOR - (Proceedings) - (10-Jul-96)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (28-Jun-96)

NEW METHODS FOR ISOLATING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (22-May-96)

DIFFERENTIATION OF VACCINE (STRAIN RESPPRRS) AND FIELD STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY RESTRICTION ENZYME ANALYSIS - (Proceedings) - (22-May-96)

EMBRYONIC AND FETAL LOSSES IN SWINE DUE TO VIRAL CAUSES - (Proceedings) - (17-Apr-96)

AN OUTLINE OF SOME OF THE CURRENT RESEARCH ON PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME BEING CONDUCTED AT THE NATIONAL ANIMAL DISEASE CENTER - (Proceedings) - (12-Apr-96)

COMPARISON AMONG STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AS TO THEIR ABILITY TO CAUSE REPRODUCTIVE FAILURE - (Peer Reviewed Journal) - (21-Mar-96)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME: UPDATE AND OVERVIEW OF THE REPRODUCTIVE DISEASE - (Proceedings) - (05-Mar-96)

DIFFERENTIATION OF VACCINE (STRAIN RESPPRRS) AND FIELD STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BY RESTRICTION ENZYME ANALYSIS - (Proceedings) - (05-Mar-96)

GROSS AND MICROSCOPIC LESIONS IN PORCINE FETUSES INFECTED WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (30-Nov-95)

VACCINATION FOR PSEUDORABIES IN THE PRESENCE OF MATERNAL IMMUNITY USING VACCINIA VIRUS RECOMBINANTS - (Abstract Only) - (14-Nov-95)

PATHOGENESIS OF PRRS REPRODUCTIVE FAILURE - (Proceedings) - (10-Nov-95)

THE EFFECT OF VARIOUS STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS ON REPRODUCTIVE EFFICIENCY OF GILTS INFECTED LATE IN GESTATION - (Proceedings) - (10-Nov-95)

TRANSMISSION RISKS WITH VIRUSES - (Proceedings) - (10-Nov-95)

ISOLATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS FROM SELECTED TISSUES OF ADULT PIGS AT VARIOUS TIMES AFTER EXPERIMENTAL EXPOSURE - (Proceedings) - (31-Oct-95)

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IMMUNITY IN SOWS - (Proceedings) - (18-Oct-95)

ALVEOLAR MACROPHAGES AS A DIAGNOSTIC SAMPLE FOR DETECTING NATURAL INFECTIONOF PIGS WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Peer Reviewed Journal) - (21-Sep-95)

THE ROLE OF BIOTECHNOLOGICALLY ENGINEERED VACCINES AND DIAGNOSTICS IN PSEUDORABIES (AUJESZKY'S DISEASE) ERADICATION STRATEGIES - (Review Article) - (08-Aug-95)

THE EFFECT OF VARIOUS STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS ON REPRODUCTIVE EFFICIENCY OF GILTS INFECTED LATE IN GESTATION - (Proceedings) - (07-Jun-95)

GROSS AND MICROSCOPIC LESIONS IN PORCINE FETUSES INFECTED WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNROME VIRUS - (Proceedings) - (31-May-95)

DIAGNOSIS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME USING INFECTED ALVEOLAR MACROPHAGES COLLECTED FROM LIVE PIGS - (Peer Reviewed Journal) - (30-May-95)

CHALLENGE OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IMMUNITY IN PREGNANT SWINE - (Proceedings) - (18-May-95)

UMBILICAL CORD LESIONS IN PORCINE FETUSES INFECTED WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS - (Proceedings) - (03-May-95)

THE USE OF BIOTECHNOLOGICALLY ENGINEERED VACCINES AND DIAGNOSTICS IN ADV ERADICATION STRATEGIES - (Proceedings) - (03-May-95)

LIMITED CROSS-PROTECTION BETWEEN TWO STRAINS OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS IN PREGNANT SWINE - (Proceedings) - (01-May-95)