Projects

INTERVENTION STRATEGIES TO CONTROL VIRAL DISEASES OF SWINE Appropriated (D)   Accession Number: 421208

USDA SWINE INFLUENZA VIRUS SURVEILLANCE SYSTEM: IN VIVO PATHOGENESIS AND TRANSMISSION AND ASSOCIATED IN VITRO STUDIES Reimbursable (R)   Accession Number: 422887

IMMUNE FACTORS IN VACCINE-ENHANCED PANDEMIC H1N1 INFLUENZA DISEASE Reimbursable (R)   Accession Number: 423110

USDA SWINE INFLUENZA VIRUS SURVEILLANCE SYSTEM: COMPUTATIONAL EVOLUTIONARY BIOLOGY OF WHOLE GENOME SEQUENCES Reimbursable (R)   Accession Number: 423118

USDA SWINE INFLUENZA A VIRUS SURVEILLANCE SYSTEM RELATED RESEARCH Specific Cooperative Agreement (S)   Accession Number: 423419

ANTIGENIC RELATEDNESS OF INFLUENZA A VIRUSES AND USE OF ANTIGENIC CARTOGRAPHY IN VACCINE STRAIN SELECTION FOR SWINE Specific Cooperative Agreement (S)   Accession Number: 421469

H1N1 INFLUENZA A VIRUS IN SWINE SUPPLEMENTAL RESEARCH PROGRAM Specific Cooperative Agreement (S)   Accession Number: 419005

SIV EPITOPES AND GENETIC FACTORS THAT AFFECT SURVEILLANCE AND IMMUNITY ELICITED BY INFLUENZA VACCINES AGAINST EMERGING INFLUENZA STRAINS Specific Cooperative Agreement (S)   Accession Number: 419073

DEVELOPMENT OF AN ORAL VACCINE VECTOR FOR INFECTIOUS DISEASES OF ANIMALS Specific Cooperative Agreement (S)   Accession Number: 419984

H1N1 INFLUENZA A VIRUS IN SWINE SUPPLEMENTAL RESEARCH PROGRAM Other (X)   Accession Number: 418864

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies - (Abstract Only) - (14-Mar-13)

Increased diversity of H3N2 influenza virus in pigs in the United States and implications for pigs and humans - (Abstract Only) - (12-Mar-13)

Genotype patterns of contemporary reassorted H3N2 virus in U.S. swine - (Peer Reviewed Journal) - (06-Mar-13)

Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1 - (Abstract Only)

Lin, K., Vincent, A.L., Roth, J.A., Kehrli, Jr., M.E., Lager, K.M., Ramamoorthy, S. 2013. Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1. In: Proceedings of the 16th Annual Conference on Vaccine Research. April 22-24, Baltimore, Maryland. p. 115.

Pathogenicity and transmission of the novel A (H3N2v) influenza virus isolated from humans in experimentally inoculated pigs - (Abstract Only) - (15-Feb-13)

Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? - (Proceedings)

Kehrli, Jr., M.E., Vincent, A.L., Gauger, P.C., Kitikoon, P., Anderson, T.K., Loving, C.L., Lager, K.M. 2013. Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? In: Proceedings of 44th Annual Meeting of the American Association of Swine Veterinarians, San Diego, CA. p. 517-519.

Cross-reactive immune responses following vaccination with a live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs - (Abstract Only)

Loving, C.L., Braucher, D.R., Brockmeier, S.L., Vincent, A.L. 2012. Cross-reactive immune responses following vaccination with a live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs. Immunological Mechanisms of Vaccination, Keystone Symposia. Paper No. 2038.

Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes - (Peer Reviewed Journal)

Butler, J.E., Sun, X., Wertz, N., Vincent, A.L., Zanella, E.L., Lager, K.M. 2013. Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes. Immunology. 138(2):134-144.

Frequency of genomic reassortment of influenza A virus in North American swine, 1998-2011 - (Peer Reviewed Journal)

Nelson, M.I., Detmer, S.E., Wentworth, D.E., Tan, Y., Schwartzbard, A., Halpin, R.A., Stockwell, T.B., Lin, X., Vincent, A.L., Gramer, M.R., Holmes, E.C. 2012. Genomic reassortment of influenza A virus in North American swine, 1998-2011. Journal of General Virology. 93(Pt 12):2584-2589.

Intranasal vaccination with replication defective adenovirus-5 encoding influenza hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs - (Peer Reviewed Journal)

Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2012. Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs. Clinical and Vaccine Immunology. 19(11):1722-1729.

Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine - (Peer Reviewed Journal)

Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Perez, D.R. 2012. Strain-dependent effects of PB1-F2 of triple reassortant H3N2 influenza viruses in swine. Journal of General Virology. 93(10):2204-2214.

Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease (VAERD) - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Richt, J.A., Janke, B.H., Sandbulte, M.R., Gauger, P.C., Loving, C.L., Webby, R.J., Garcia-Sastre, A. 2012. Live attenuated influenza vaccine provides superior protection from heterologous infection in pigs with maternal antibodies without inducing vaccine associated enhanced respiratory disease. Journal of Virology. 86(19):10597-10605.

Heightened adaptive immune responses following vaccination with a temperature-sensitive, live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs - (Peer Reviewed Journal)

Loving, C.L., Vincent, A.L., Pena, L., Perez, D.R. 2012. Heightened adaptive immune responses following vaccination with a temperature-sensitive, live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs. Vaccine. 30(40):5830-5838.

Frequent global transmission of H1N1pdm09 influenza viruses from humans to swine, 2009-2011 - (Peer Reviewed Journal)

Nelson, M.I., Gramer, M.R., Vincent, A.L., Holmes, E.C. 2012. Global transmission of influenza viruses from humans to swine. Journal of General Virology. 93(10):2195-2203.

Flu virus continues to evolve in swine - (Trade Journal)

Gauger, P.C., Zhang, J., Vincent, A.L. 2012. Flu virus continues to evolve in swine. National Hog Farmer. Available: http://nationalhogfarmer.com/health/flu-virus-continues-evolve-swine.

Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 - (Abstract Only)

Cheung, A.K., Kehrli, Jr., M.E., Lager, K.M., Gauger, P.C., Rohrer, G.A., Michael, D.D., Miller, L.C., Vincent, A.L., Braucher, D.R. 2012. Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 [abstract]. IXth International Congress of Veterinary Virology. p. 189-190.

Evolution of H3N2v viruses in North American swine and humans, 2009-2011 - (Peer Reviewed Journal)

Nelson, M.I., Vincent, A.L., Kitikoon, P., Holmes, E.C., Gramer, M.R. 2012. The evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009-2011. Journal of Virology. 86(16):8872-8878.

Simultaneous infection of pigs and people with triple reassortant swine influenza virus H1N1 at a U.S. county fair - (Peer Reviewed Journal)

Killian, M.L., Swenson, S.L., Vincent, A.L., Landgraf, J.G., Shu, B., Lindstrom, S., Xu, X., Klimov, A., Zhang, Y., Bowman, A.S. 2013. Simultaneous infection of pigs and people with triple-reassortant swine influenza virus H1N1 at a U.S. county fair. Zoonoses and Public Health. 60(3):196-201.

Comparison of 2010-2011 H3N2 influenza A viruses isolated from swine and the A(H3N2)v isolated from humans in 2011 - (Abstract Only)

Kitikoon, P., Vincent, A.L., Gauger, P., Schlink, S.N., Bayles, D.O., Gramer, M., Darnell, D., Webby, R., Lager, K.M., Swenson, S., Klimov, A. 2012. Comparison of 2010-2011 H3N2 influenza A viruses isolated from swine and the A(H3N2)v isolated from humans in 2011 [abstract]. American Society for Virology 31st Annual Meeting. p. 102.

Comparison of human-like H1 (delta-cluster) influenza A viruses in the swine host - (Peer Reviewed Journal)

Ciacci Zanella, J.R., Vincent, A.L., Zanella, E.L., Lorusso, A., Loving, C.L., Brockmeier, S.L., Gauger, P.C., Janke, B.H., Gramer, M.R. 2012. Comparison of human-like H1 (delta-cluster) influenza A viruses in the swine host. Influenza Research and Treatment. Available: http://www.hindawi.com/journals/irt/2012/329029/.

Influenza A virus and secondary bacterial infection in swine - (Abstract Only) - (02-Apr-12)

Pathogenicity and transmission in pigs of the novel A(H3N2)v influenza virus isolated from humans and characterization of swine H3N2 viruses isolated in 2010-2011 - (Peer Reviewed Journal)

Kitikoon, P., Vincent, A.L., Gauger, P.C., Schlink, S.N., Bayles, D.O., Gramer, M.R., Darnell, D., Webby, R.J., Lager, K.M., Swenson, S.L., Klimov, A. 2012. Pathogenicity and transmission in pigs of the novel A(H3N2)v influenza virus isolated from humans and characterization of swine H3N2 viruses isolated in 2010-2011. Journal of Virology. 86(12):6804-6814.

Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine - (Peer Reviewed Journal)

Pena, L., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Lorusso, A., Perez, D.R. 2012. Restored PB1-F2 into the 2009 pandemic H1N1 influenza virus has minimal effects in swine. Journal of Virology. 86(10):5523-5532.

Global coordination for swine influenza virus surveillance and research: what are we missing from the big picture? - (Proceedings)

Vincent, A.L., Kitikoon, P., Gauger, P.C., Gramer, M.R., Lorusso, A., Lager, K.M., Ciacci-Zanella, J.R. 2012. Global coordination for swine influenza virus surveillance and research: what are we missing from the big picture? In: Proceedings of the 43rd American Association of Swine Veterinarians Annual Meeting, March 10-13, 2012, Denver, Colorado. p. 507-512.

Swine influenza virus: epidemiology and vaccine concerns - (Proceedings)

Gauger, P.C., Vincent, A.L. 2012. Swine influenza virus: epidemiology and vaccine concerns. In: Proceedings of the 19th Annual Swine Disease Conference for Swine Practitioners, November 10-11, 2011, Ames, Iowa. p. 13-21.

The changing face of swine influenza virus - (Trade Journal)

Vincent, A.L., Gauger, P.C. 2011. The changing face of swine influenza virus. Pork Magazine. Available: http://www.porknetwork.com/pork/smart-thinking/The-Changing-Face-of-Swine-Influenza-Virus-133249878.html.

Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs - (Peer Reviewed Journal)

Kappes, M.A., Sandbulte, M.R., Platt, R., Wang, C., Lager, K.M., Henningson, J.N., Lorusso, A., Vincent, A.L., Loving, C.L., Roth, J.A., Kehrli Jr, M.E. 2012. Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs. Vaccine. 30(2):280-288.

Influenza A virus in pigs – protection, provocation and predisposition - (Abstract Only) - (13-Oct-11)

Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine - (Abstract Only)

Gauger, P., Vincent, A., Loving, C., Lorusso, A., Lager, K., Pena, L., Perez, D. 2011. Modified live virus vaccine induces a distinct immune response profile compared to inactivated influenza A virus vaccines in swine [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 148.

Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs - (Abstract Only)

Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2011. Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 131.

Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs – exacerbation associated with vaccination - (Abstract Only)

Loving, C.L., Vincent, A.L., Brockmeier, S.L., Henningson, J.N., Braucher, D.R., De Souza Rajao, D. 2011. Host response to secondary bacterial infection associated with antecedent influenza virus infection in pigs - exacerbation associated with vaccination [abstract]. Autumn Immunology Conference. Poster No. 140.

DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs - (Peer Reviewed Journal)

Gorres, J.P., Lager, K.M., Kong, W.P., Royals, M., Todd, J.P., Vincent, A.L., Wei, C.J., Loving, C.L., Zanella, E.L., Janke, B., Kehrli, Jr., M.E., Nabel, G.J., Rao, S.S. 2011. DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs. Clinical and Vaccine Immunology. 18(11):1987-1995.

Isolation and characterization of pandemic H1N1 influenza viruses in pigs in Brazil - (Peer Reviewed Journal)

Schaefer, R., Zanella, J.R.C., Brentano, L., Vincent, A.L., Ritterbusch, G.A., Silveira, S., Caron, L., Mores, N. 2011. Isolation and characterization of pandemic H1N1 influenza viruses in pigs in Brazil. Pesquisa Veterinaria Brasileira. 31(9):761-767.

A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice - (Peer Reviewed Journal)

Shao, H., Ye, J., Vincent, A.L., Edworthy, N., Ferrero, A., Qin, A., Perez, D. 2011. A novel monoclonal antibody effective against lethal challenge with swine-lineage and 2009 pandemic H1N1 influenza viruses in mice. Virology. 417(2):379-384.

Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2 - (Peer Reviewed Journal)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Cheung, A.K., Butler, J.E., Kehrli, Jr., M.E. 2011. Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2. Veterinary Microbiology. 154(1-2):185-190.

Characterization of H1N1 swine influenza viruses circulating in Canadian pigs in 2009 - (Peer Reviewed Journal)

Nfon, C.K., Berhane, Y., Hisanaga, T., Zhang, S., Handel, K., Kehler, H., Labrecque, O., Lewis, N.S., Vincent, A.L., Copps, J., Alexandersen, S., Pasick, J. 2011. Characterization of H1N1 swine influenza viruses circulating in Canadian pigs in 2009. Journal of Virology. 85(17):8667-8679.

Antigenic map of hemagglutinin (H) 1 proteins of 2010-2011 swine influenza viruses (SIV) in the U.S. swine population - (Abstract Only) - (07-Jun-11)

Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b - (Peer Reviewed Journal)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2011. Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b. Veterinary Microbiology. 153(3-4):229-239.

Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs - (Peer Reviewed Journal)

Platt, R., Vincent, A.L., Gauger, P.C., Loving, C.L., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E., Kimura, K., Roth, J.A. 2011. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Veterinary Immunology and Immunopathology. 142(3-4):252-257.

Influenza A virus in swine - moving beyond 2009 - (Proceedings)

Vincent, A.L., Lorusso, A., Lager, K.M., Gauger, P.C., Gramer, M.R., Ciacci-Zanella, J.R. 2011. Influenza A virus in swine - moving beyond 2009. In: Proceedings of the 6th International Symposium on Emerging and Re-emerging Pig Diseases, June 12-15, 2011, Barcelona, Spain. p. 35-37.

Spatial dynamics of human-origin H1 influenza A v irus in North American swine - (Peer Reviewed Journal)

Nelson, M.I., Lemey, P., Tan, Y., Vincent, A., Lam, T.T-Y., Detmer, S., Viboud, C., Suchard, M.A., Rambaut, A., Holmes, E.C., Gramer, M. 2011. Spatial dynamics of human-origin H1 influenza A virus in North American swine. PLoS Pathogens. 7(6):e1002077.

Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus - (Peer Reviewed Journal)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A. 2011. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine. 29(15):2712-2719.

Utility of a Panviral Microarray for Detection of Swine Respiratory Viruses in Clinical Samples - (Peer Reviewed Journal)

Nicholson, T.L., Kukielka, D., Vincent, A.L., Brockmeier, S.L., Miller, L.C., Faaberg, K.S. 2011. Utility of a panviral microarray for detection of swine respiratory viruses in clinical samples. Journal of Clinical Microbiology. 49(4):1542-1548.

Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States - (Peer Reviewed Journal)

Chen, L.M., Rivailler, P., Hossain, J.M., Carney, P., Balish, A., Perry, I., Davis, C.T., Garten, R., Shu, B., Xu, X., Klimov, A., Paulson, J.C., Cox, N.J., Swenson, S., Stevens, J., Vincent, A., Gramer, M., Donis, R.O. 2011. Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States. Virology. 412(2):401-410.

Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1in pigs - (Abstract Only)

Loving, C.L., Vincent, A.L., Pena, L., Perez, D. 2011. Immune responses elicited to a live-attenuated influenza virus vaccine compared to a traditional whole-inactivated virus vaccine for pandemic H1N1 in pigs [abstract]. Keystone Symposium, Immunity in the Respiratory Tract. Poster No. 228. p. 163.

Innate immune responses to pathogens involved in the porcine respiratory disease complex - (Abstract Only)

Brockmeier, S.L., Loving, C.L., Vincent, A.L. 2011. Innate immune responses to pathogens involved in the porcine respiratory disease complex [abstract]. Keystone Symposia, Immunity in the Respiratory Tract. Poster No. 114. p. 149.

Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008 - (Peer Reviewed Journal)

Lorusso, A., Vincent, A.L., Harland, M.L., Alt, D., Bayles, D.O., Swenson, S.L., Gramer, M.R., Russel, C.A., Smith, D.J., Lager, K.M., Lewis, N.S. 2011. Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008. Journal of General Virology. 92(Pt 4):919-930.

Pandemic H1N1 influenza: zoonoses are a two-way street - (Abstract Only) - (16-Nov-10)

Innate Immune Responses are Enhanced in Pigs After Sequential Infection with Influenza Virus and Haemophilus parasuis - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Innate immune responses are enhanced in pigs after sequential infection with influenza virus and Haemophilus parasuis [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 165.

Swine Influenza Virus: Emerging Understandings - (Proceedings)

Vincent, A.L., Lorusso, A., Lager, K.M., Gauger, P.C., Gramer, M.R., Ciacci-Zanella, J.R. 2010. Swine influenza virus: emerging understandings. In: Proceedings of 18th Annual Swine Disease Conference for Swine Practitioners, November 4-5, 2010, Ames, IA. p. 57-62.

Genetic and Antigenic Characterization of H1 Influenza Viruses from United States Swine Prior to the Emergence of the 2009 Pandemic H1N1 - (Abstract Only)

Lorusso, A., Vincent, A., Harland, M., Alt, D., Bayles, D., Swenson, S., Gramer, M., Russell, C., Smith, D., Lager, K., Lewis, N. 2010. Genetic and antigenic characterization of H1 Influenza Viruses from United States swine prior to the emergence of the 2009 pandemic H1N1 [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 194.

Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs - (Abstract Only)

Platt, R., Gauger, P., Kimura, K., Roth, J., Vincent, A., Loving, C., Zanella, E., Lager, K., Kehrli, M. 2010. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 085P/85P.

Pathogenesis Studies of the 2009 Pandemic Influenza Virus and Pseudorabies Virus From Wild Pigs In Swine - (Proceedings)

Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Miller, L.C., Kehrli, Jr., M.E. 2010. Pathogenesis studies of the 2009 pandemic influenza virus and pseudorabies virus from wild pigs in swine. In: Proceedings of the Brazilian Society for Virology XXI Meeting, October 18-20, 2010, Gramado, Rio Grande do Sul, Brazil. p. 33-34.

Safety and efficacy of a novel live attenuated influenza vaccine against pandemic H1N1 in swine - (Peer Reviewed Journal)

Pena, L., Vincent, A.L., Ye, J., Ciacci-Zanella, J.E., Angel, M., Lorusso, A., Gauger, P.C., Janke, B.H., Loving, C.L., Perez, D.R. 2011. Safety and efficacy of a novel live attenuated influenza vaccine against pandemic H1N1 in swine. Influenza and Other Respiratory Viruses. 5(S1):341-344.

A monoclonal antibody-based ELISA for differential diagnosis of 2009 pandemic H1N1 - (Peer Reviewed Journal)

Shao, H., Ye, J., Vincent, A.L., Song, H., Hickman, D., Qi, A., Lamichhane, C., Perez, D.R. 2011. A monoclonal antibody-based ELISA for differential diagnosis of 2009 pandemic H1N1. Influenza and Other Respiratory Viruses. 5(Suppl.1):138-142.

Influenza Vaccination in the Face of Maternal Antibody Results in Enhanced Pneumonia Following Heterologous, Homosubtypic Influenza Challenge - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Kehrli, Jr., M.E. 2010. Influenza vaccination in the face of maternal antibody results in enhanced pneumonia following heterologous, homosubtypic influenza challenge [abstract]. Keystone Symposia, Immunological Mechanisms of Vaccination. Paper No. 243.

Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Influenza Virus Coinfection with Bordetella bronchiseptica Enhances Bacterial Colonization and Host Responses Exacerbating Pulmonary Lesions. Microbial Pathogenesis. 49(5):237-245.

Enhanced Pneumonia and Proinflammatory Cytokine Response in Pigs Challenged with Pandemic 2009 A/H1N1 Influenza Virus Following Vaccination with an Inactivated delta-Cluster H1N2 Virus - (Abstract Only)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.A., Roth, J.A. 2010. Enhanced pneumonia and proinflammatory cytokine response in pigs challenged with pandemic 2009 A/H1N1 influenza virus following vaccination with an inactivated delta-cluster H1N2 virus [abstract]. International Conference on Emerging Infectious Diseases. Paper No. L1345.

Zoonoses: USDA ARS Lessons Learned During Novel Influenza H1N1 Investigations - (Abstract Only)

Vincent, A.L. 2010. Zoonoses: USDA ARS Lessons Learned During Novel Influenza H1N1 Investigations [abstract]. American Veterinary Medical Association 147th Annual Convention. Paper No. 8515.

Development and validation of a real-time RT-PCR assay for the 2009 pandemic H1N1 virus in veterinary specimens - (Abstract Only)

Spackman, E., Suarez, D.L., Killian, M.L., Koster, L., Swenson, S., Pedersen, J., Vincent, A.L., Lager, K.M., Jenkins-Moore, M., Schmitt, B. 2010. Development and validation of a real-time RT-PCR assay for the 2009 pandemic H1N1 virus in veterinary specimens [abstract]. Swine Origin H1N1: The First Pandemic of the 21st Century meeting, April 18-20, 2010, Atlanta, Georgia. p. 30.

Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate - (Abstract Only)

Buehler, J., Mccullough, D., Loving, C.L., Vincent, A.L., Lager, K.M., Miller, C. 2010. Investigation of the Function of the Influenza A Virus PB1-F2 Protein During Infection of Swine and Human Cells with a Predominant Circulating Swine Virus Isolate [abstract]. American Society for Virology Meeting. p. 279.

Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses - (Proceedings)

Lager, K.M., Vincent, A.L., Gauger, P.C., Senne, D.A., Swayne, D.E., Miller, L.C., Richt, J., Ma, W., Suarez, D.L., Kehrli Jr, M.E. 2010. Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 79.

Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs - (Proceedings)

Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.R., Kehrli, Jr., M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 299.

Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States - (Proceedings)

Vincent, A.L., Harland, M.L., Lorusso, A., Alt, D.P., Bayles, D.O., Swenson, S.L., Gramer, M.R., Lager, K.M., Lewis, N. 2010. Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 259.

Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs - (Proceedings)

Vincent, A.L., Ciacci Zanella, J.R., Lorusso, A., Zanella, E.L., Lager, K.M., Gauger, P.C., Janke, B.H., Kehrli, Jr., M.E. 2010. Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 74.

Human-Like H1 (Delta-Cluster) Swine Influenza Virus (SIV) Can Efficiently Replicate, Transmit, Cause Lung Pathology and Induce Humoral Immune Responses in the Swine Host - (Proceedings)

Ciacci Zanella, J.R., Vincent, A.L., Zanella, E.L., Brockmeier, S. 2010. Human-Like H1 (Delta-Cluster) Swine Influenza Virus (SIV) Can Efficiently Replicate, Transmit, Cause Lung Pathology and Induce Humoral Immune Responses in the Swine Host. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 262.

Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs - (Proceedings)

Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M. 2010. Enhanced Pneumonia With Pandemic 2009 A/H1N1 Swine Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 255.

Challenge of Pigs with Natural Immunity to H1 and H3 Swine Influenza Virus with Pandemic 2009 H1N1 Influenza Virus - (Proceedings)

Ciacci Zanella, J.R., Lager, K.M., Vincent, A.L., Zanella, E.L., Gava, D. 2010. Challenge of Pigs with Natural Immunity to H1 and H3 Swine Influenza Virus with Pandemic 2009 H1N1 Influenza Virus. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 253.

Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection - (Proceedings)

Loving, C.L., Brockmeier, S., Vincent, A.L. 2010. Prior Swine Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus parasuis Infection. In: Proceedings of the Pig Veterinary Society International Congress, July 18-21, 2010, Vancouver, Canada. p. 264.

Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2 - (Proceedings)

Kehrli, Jr., M.E., Gauger, P.C., Cheung, A.K., Vincent, A.L., Lager, K.M. 2010. Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 332.

A Set of Novel Monoclonal Antibodies Against Swine-Origin Pandemic H1N1 Differentiate Swine H1N1 and Human Seasonal H1N1 - (Abstract Only)

Shao, H., Ye, J., Song, H., Lamichhane, C., Qin, A., Vincent, A.L., Perez, D.R. 2010. A Set of Novel Monoclonal Antibodies Against Swine-Origin Pandemic H1N1 Differentiate Swine H1N1 and Human Seasonal H1N1 [abstract]. International Symposium on Neglected Influenza Viruses. Poster #P-022. p. 41.

One Step Real-Time RT-PCR for 2009 Pandemic H1N1 Matrix Gene Detection in Swine Samples - (Proceedings)

Lorusso, A., Faaberg, K.S., Killian, M., Koster, L., Vincent, A.L. 2010. One Step Real-Time RT-PCR for 2009 Pandemic H1N1 Matrix Gene Detection in Swine Samples [abstract]. American Association of Swine Veterinarians. American Association of Swine Veterinarians. p. 369.

Antecedent Influenza Virus Infection Enhances Pulmonary Responses to Secondary Haemophilus Infection in a Porcine Co-Infection Model - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L. 2010. Antecedent Influenza virus infection enhances pulmonary responses to secondary Haemophilus infection in a porcine co-infection model [abstract]. American Association of Immunologists. Paper No. 803219.

Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs - (Peer Reviewed Journal)

Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.L., Kehrli Jr, M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs. Vaccine 28(15):2782-2787.

Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs - (Proceedings)

Vincent, A.L., Lager, K.M., Harland, M.L., Lorusso, A., Ciacci-Zanella, J.R., Zanella, E.L., Kehrli, Jr., M.E., Gauger, P.C., Janke, B.H., Klimov, A. 2010. Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs. In: Proceedings of the 41st Annual Meeting of the American Association of Swine Veterinarians, March 6-9, 2010, Omaha, Nebraska. p. 495-497.

Summary of Control Issues for Swine Influenza - (Abstract Only)

Vincent, A.L., Lager, K.M., Richt, J.A., Ma, W., Janke, B.H. 2010. Summary of control issues for swine influenza [abstract]. International Symposium on Neglected Influenza Viruses. p. 22.

One-Step Real-Time RT-PCR for Pandemic Influenza A Virus (H1N1) 2009 Matrix Gene Detection in Swine Samples - (Peer Reviewed Journal)

Lorusso, A., Faaberg, K.S., Killian, M., Koster, L., Vincent, A.L. 2010. One-Step Real-Time RT-PCR for Pandemic Influenza A Virus (H1N1) 2009 Matrix Gene Detection in Swine Samples. Journal of Virological Methods. 164(1-2):83-87.

Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Faaberg, K.S., Harland, M., Zanella, E.L., Zanella, J.R., Kehrli, Jr., M.E., Janke, B.H., Klimov, A. 2009. Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera. Influenza and Other Respiratory Viruses. 4(2):53-60.

Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Harland, M., Lorusso, A., Zanella, E., Ciacci-Zanella, J.R., Kehrli, Jr., M.E., Klimov, A. 2009. Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork. PLoS ONE. 4:(12):e8367.

Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions - (Abstract Only)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Palmer, M.V., Sacco, R.E., Nicholson, T.L. 2010. Swine influenza virus co-infection with Bordetella bronchiseptica enhances bacterial colonization and host immune responses exacerbating pulmonary lesions [abstract]. Conference Research Workers Disease Meeting. Paper No. 130.

Swine Influenza Update - (Proceedings)

Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Lorusso, A., Faaberg, K.S., Kehrli, Jr., M.E. 2009. Swine influenza update. In: Proceedings of the 17th Annual Swine Disease Conference, November 5-6, 2009, Iowa State University, Ames, Iowa. pp. 128-131.

Identification and Characterization of a Highly Virulent Triple Reassortant H1N1 Swine Influenza Virus in the Midwest of the United States - (Peer Reviewed Journal)

Ma, W., Vincent, A.L., Lager, K.M., Janke, B.H., Henry, S.C., Rowland, R.R., Hesse, R.A., Richt, J.A. 2010. Identification and Characterization of a Highly Virulent Triple Reassortant H1N1 Swine Influenza Virus in the United States. Virus Genes. 40(1):28-36.

Detection of Anti-Influenza A Nucleoprotein Antibodies in Pigs Using a Commercial Influenza Epitope-Blocking Enzyme-Linked Immunosorbent Assay Developed for Avian Species - (Peer Reviewed Journal)

Ciacci-Zanella, J.R., Vincent, A.L., Prickett, J.R., Zimmerman, S.M., Zimmerman, J.J. 2010. Detection of Anti-Influenza A Nucleoprotein Antibodies in Pigs Using a Commercial Influenza Epitope-Blocking Enzyme-Linked Immunosorbent Assay Developed for Avian Species. Journal of Veterinary Diagnostic Investigation. 22(1):3-9.

One Step Real-Time RT-PCR for 2009 Pandemic H1N1 Matrix Gene Detection and Quantitation in Clinical Samples - (Abstract Only)

Lorusso, A., Faaberg, K.S., Killian, M., Koster, L., Vincent, A.L. 2010. One Step Real-Time RT-PCR for 2009 Pandemic H1N1 Matrix Gene Detection and Quantitation in Clinical Samples [abstract]. American Association of Swine Veterinarians. p. 369.

Swine Influenza Matrix 2 (M2) Protein Contributes to Protection Against Infection with Different H1 Swine Influenza Virus (SIV) Isolates - (Peer Reviewed Journal)

Kitikoon, P., Vincent, A.L., Janke, B.H., Erickson, B., Strait, E.L., Yu, S., Gramer, M.R., Thacker, E.L. 2009. Swine Influenza Matrix 2 (M2) Protein Contributes to Protection Against Infection with Different H1 Swine Influenza Virus (SIV) Isolates. Vaccine. 28(2):523-531.

Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Gramer, M.R., Richt, J.A., Janke, B.H. 2009. Characterization of a Newly Emerged Genetic Cluster of H1N1 and H1N2 Swine Influenza Virus in the U.S. Virus Genes. 39(2):176-185.

Vaccine efficacy and immune response to swine influenza virus challenge in pigs infected with porcine reproductive and respiratory syndrome virus at the time of SIV-vaccination - (Peer Reviewed Journal)

Kitikoon, P., Vincent, A.L., Jones, K.R., Nilubol, D., Yu, S., Janke, B.H., Thacker, B.J., Thacker, E.L. 2009. Vaccine Efficacy and Immune Response to Swine Influenza Virus Challenge in Pigs Infected with Porcine Reproductive and Respiratory Syndrome Virus at the Time of SIV-Vaccination. Veterinary Microbiology. 139(3-4):235-244.

Clinical and pathological responses of pigs from two genetically diverse commercial lines to porcine respiratory and reproductive syndrome virus infection - (Peer Reviewed Journal)

Doeschl-Wilson, A.B., Kyriazakis, I., Vincent, A., Rothschild, M.F., Thacker, E., Galina-Pantoja, L. 2009. Clinical and Pathological Responses of Pigs from Two Genetically Diverse Commercial Lines to Porcine Respiratory and Reproductive Syndrome Virus Infection. Journal of Animal Science. 87(5):1638-1647.

Characterization of an Influenza A Virus Isolated from Pigs During an Outbreak of Respiratory Disease in Swine and People at a County Fair in the United States - (Peer Reviewed Journal)

Vincent, A.L., Swenson, S.L., Lager, K.M., Gauger, P.C., Loiacono, C., Zhang, Y. 2009. Characterization of an Influenza A Virus Isolated from Pigs During an Outbreak of Respiratory Disease in Swine and People at a County Fair in the United States. Veterinary Microbiology. 137(1-2):51-59.

Development of a replication defective adenovirus 5 vector expressing porcine interleukin-18 and a mutated analog - (Abstract Only)

Kappes, M.A., Ma, W., Richt, J.A., Lager, K.M., Vincent, A.L., Roth, J.A., Murtaugh, M.P., Kehrli, Jr., M.E. 2008. Development of a Replication Defective Adenovirus 5 Vector Expressing Porcine Interleukin-18 and a Mutated Analog [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 99P. p. 121.

The role of swine in the generation of novel influenza viruses - (Peer Reviewed Journal)

Ma, W., Lager, K.M., Vincent, A.L., Janke, B.H., Gramer, M.R., Richt, J.A. 2009. The Role of Swine in the Generation of Novel Influenza Viruses. Zoonoses and Public Health. 56(6-7):326-337.

Differences in immune response of pigs challenged with a high versus low dose inoculum of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)

Loving, C.L., Brockmeier, S.L., Vincent, A.L., Lager, K.M., Sacco, R.E. 2008. Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. Viral Immunology. 21(3):315-325.

Investigating the porcine immune reponse to Haemophilus parasuis - (Abstract Only) - (15-May-08)

Experimental Evaluation of a Swine Influenza Virus Isolated from a County Fair Outbreak in the United States - (Proceedings)

Vincent, A.L., Swenson, S.L., Lager, K.M., Gauger, P.C., Loiacono, C.M., Beach, T., Landgraf, J., Zhang, Y. 2008. Experimental Evaluation of a Swine Influenza Virus Isolated from a County Fair Outbreak in the United States. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. p. 7.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Proceedings)

Brockmeier, S., Vincent, A.L., Loving, C.L., Nicholson, T.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica. In: Proceedings of the 20th International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. 1:10.

Pathogenesis of PCV2a and PCV2b virus in germ-free pigs - (Proceedings)

Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2008. Pathogenesis of PCV2a and PCV2b Virus in Germ-Free pigs. In: Proceedings of the International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. Paper No. OR.01.28.

Swine Influenza Viruses: a North American Perspective - (Review Article)

Vincent, A.L., Ma, W., Lager, K.M., Janke, B.H., Richt, J.A. 2008. Swine Influenza Viruses: a North American Perspective. Advances in Virus Research. 72:127:154.

Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract Only)

Brockmeier, S., Loving, C.L., Nicholson, T.L., Vincent, A.L., Sacco, R.E. 2008. Early Induction of Cytokines in Pigs Coinfected with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. American Society for Microbiology Meeting, June 2-4, 2008, Boston, Massachusetts. 2008 CDROM.

Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica - (Abstract Only)

Brockmeier, S., Vincent, A.L., Nicholson, T.L., Sacco, R.E., Palmer, M.V. 2007. Coinfection of Pigs with Swine Influenza Virus and Bordetella bronchiseptica [abstract]. In: United States Japan Natural Resources Animal and Avian Health Panel, December 5, 2007, Tsukuba, Japan. p. 25.

Viral Reassortment and Transmission after Coinfection of Pigs with two Swine Influenza Viruses - (Abstract Only)

Ma, W., Lager, K.M., Fleckenstein, E.S., Lekcharoensuk, P., Janke, B.H., Vincent, A.L., Webby, R.J., Richt, J.A. 2007. Viral reassortment and transmission after coinfection of pigs with 2 swine influenza viruses [abstract]. Conference of Research Workers in Animal Diseases Annual Meeting. Paper No. 146. p. 147.

Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine - (Peer Reviewed Journal)

Vincent, A.L., Ma, W., Lager, K.M., Janke, B.H., Webby, R.J., Garcia-Sastre, A., Richt, J.A. 2007. Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine. Vaccine. 25:7999-8009.

VIRUS VACCINE RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER: LESSONS FROM SWINE INFLUENZA VIRUS AND BOVINE VIRAL DIARRHEA VIRUS - (Abstract Only)

Kehrli, Jr., M.E., Vincent, A.L., Richt, J.A., Wesley, R.D., Lager, K.M., Ridpath, J.F., Kimura, K., Roth, J.A. 2007. Virus vaccine research at the National Animal Disease Center: lessons from swine influenza virus and bovine viral diarrhea virus [abstract]. The Changing Landscape of Vaccine Development: Vaccines for Global Health. The University of Texas Medical Branch, Sealy Center for Vaccine Development. p. 14

Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate - (Proceedings)

Cheung, A.K., Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E. 2007. Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate. In: Proceedings of the 13th International World Association of Veterinary Laboratory Diagnosticians Symposium, November 11-14, 2007, Melbourne, Australia. p. 213.

Isolation of reassortant H2N3 avian/swine influenza virus from pigs in the United States - (Abstract Only)

Gramer, M., Goyal, S., Patnayak, D., Lager, K., Ma, W., Vincent, A., Richt, J., Webby, R. 2007. Isolation of reassortant H2N3 avian/swine influenza virus from pigs in the United States [abstract]. American Association of Veterinary Laboratory Diagnosticians 50th Annual Conference. p. 122.

Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Janke, B.H., Gramer, M.R., Richt, J.R. 2008. Failure of protection and enhanced pneumonia with a US H1N2 swine influenza virus in pigs vaccinated with an inactivated classical swine H1N1 vaccine. Veterinary Microbiology. 126(4):310-323.

Comparison of the pathogenicity of porcine circovirus type 2 group 1 and group 2 isolates - (Proceedings)

Cheung, A.K., Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T. 2007. Comparison of the pathogenicity of porcine circovirus type 2 group 1 and group 2 isolates. In: Proceedings of the 5th International Symposium on Emerging and Re-Emerging Pig Diseases, June 24-27, 2007, Krakow, Poland. p. 273.

Mortality in pigs given PCV2 virus derived from DNA clones - (Peer Reviewed Journal)

Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2007. Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Veterinary Record. 161(12):428-429.

Quantification of PCV2 capsid transcript in peripheral blood mononuclear cells (PBMCs) in vitro - (Peer Reviewed Journal)

Yu, S., Vincent, A., Opriessnig, T., Carpenter, S., Kitikoon, P., Halbur, P.G., Thacker, E. 2007. Quantification of PCV2 capsid transcript in peripheral blood mononuclear cells (PBMCs) in vitro. Veterinary Microbiology. 123:34-42.

Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs - (Abstract Only)

Brockmeier, S., Vincent, A.L., Sacco, R.E., Nicholson, T.L., Palmer, M.V. 2007. Coinfection with Swine Influenza Virus and Bordetella bronchiseptica in Pigs [abstract]. American Society for Microbiology Meeting, May 21-25,2007, Toronto, Canada. 2007 CD-ROM.

PCVAD diagnosis and emerging diseases: building a systematic approach - (Proceedings)

Lager, K.M., Gauger, P.C., Vincent, A.L., Cheung, A.K. 2007. PCVAD diagnosis and emerging diseases: building a systematic approach. In: Proceedings of the American Association of Swine Veterinarians Annual Meeting, March 3-6, 2007, Orlando, Florida. p. 525-528.

Identification of two genotype subgroups of porcine circovirus type 2 in swine herds of the United States - (Abstract Only)

Cheung, A.K., Lager, K.M., Vincent, A.L. 2006. Identification of two genotype subgroups of porcine circovirus type 2 in swine herds of the United States [abstract]. Conference of Research Workers in Animal Diseases 87th Annual Meeting. Paper No. 171. p. 78.

The selected B cell population in PRRS has a naive phenotype, undiversified repertoire and unusually hydrophobic HCDR3 - (Abstract Only)

Butler, J.E., Weber, P., Lemke, C.D., Kimura, K., Sinkora, M., Vincent, A.L., Vorwald, A.C., Lager, K.M. 2006. The selected B cell population in PRRS has a naive phenotype, undiversified repertoire and unusually hydrophobic HCDR3 [abstract]. 2006 International PRRS Symposium. Paper No. 33.

Detection of two porcine circovirus type 2 genotypic groups in United States swine herds - (Peer Reviewed Journal)

Cheung, A.K., Lager, K.M., Kohutyuk, O.I., Vincent, A.L., Henry, S.C., Baker, R.B., Rowland, R.R., Dunham, A.G. 2007. Detection of two porcine circovirus type 2 genotypic groups in United States swine herds. Archives of Virology. 152(5):1035-1044.

Diagnostics of Severe PCVAD - (Proceedings)

Lager, K.M., Vincent, A.L., Cheung, A.K., Gauger, P.C. 2006. Diagnostics of severe PCVAD. In: Proceedings of the 14th Annual Swine Disease conference for Practitioners, November 9-10, 2006, Ames, Iowa. p. 131-133.

Analysis of activated immune cell populations in the bronchoalveolar lavage fluid of pigs immunized and/or infected with SIV - (Abstract Only)

Kimura, K., Vincent, A.L., Richt, J.A., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Effect of vaccination and/or challenge of swine influenza virus on the proportion of activated cells in bronchoalveolar lavage fluid [abstract]. Great Lakes International Imaging and Flow Cytometry Association. Paper No. 7.

Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine - (Peer Reviewed Journal)

Richt, J.A, Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Loiacono, C.M., Janke, B.H., Wu, W.H., Yoon, K.J., Webby, R.J., Solorzano, A., Garcia-Sastre, A. 2006. Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine. Journal of Virology. 80(22):11009-11018.

EVALUATION OF HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA VIRUSES FROM THE UNITED STATES - (Peer Reviewed Journal)

Vincent, A.L., Lager, K.M., Ma, W., Lekcharoensuk, P., Gramer, M.R., Loiacono, C., Richt, J.A. 2006. Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States. Veterinary Microbiology. 118(3-4):212-222.

INFLUENZA VACCINE RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER - (Proceedings) - (30-Jun-06)

VACCINATION OF PIGS AGAINST SWINE INFLUENZA VIRUSES USING A NS1-DELETED MODIFIED LIVE VACCINE - (Abstract Only)

Richt, J.A., Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Ma, W., Loiacono, C.M., Wu, W.H., Webby, R.J., Solorzano, A., Garcia-Sastre, A. 2006. Vaccination of pigs against swine influenza viruses using a NS1-deleted modified live vaccine [abstract]. 13th International Conference on Negative Strand Viruses. Paper No. 277. p. 198.

FAILURE OF CROSS-PROTECTION BY INACTIVATED VACCINES FOR TWO U.S. H1 SWINE INFLUENZA VIRUS (SIV) ISOLATES - (Proceedings)

Vincent, A.L., Lager, K.M., Gramer, M.G., Richt, J.A., Janke, B.H. 2006. Failure of cross-protection by inactivated vaccines for two U.S. H1 swine influenza virus (SIV) isolates. In: Proceedings of the 19th International Pig Veterinary Society Congress, July 16-19, 2006, Copenhagen, Denmark. p. 266.

ASSAY FOR PROLIFERATION OF PORCINE PBMC WITH OREGON GREEN 488 AND ITS APPLICATION FOR EVALUATION OF T CELL RESPONSIVENESS TO SWINE INFLUENZA VIRUS - (Abstract Only)

Kimura, K., Vincent, A.L., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Assay for proliferation of porcine PBMC with Oregon Green 488 and its application for evaluation of T cell responsiveness to swine influenza virus [astract]. Journal of Immunology Supplement. 176:S118. Paper No. 59.12.

NOVEL SWINE INFLUENZA VIRUS SUBTYPE H3N1, UNITED STATES - (Peer Reviewed Journal)

Lekcharoensuk, P., Lager, K.M., Vemulapalli, R., Woodruff, M., Vincent, A.L., Richt, J.A. 2006. Novel swine influenza virus subtype H3N1, United States. Emerging Infectious Diseases. 12(5):787-794.

ACUTE BVDV INFECTIONS IN NON BOVINE SPECIES - (Abstract Only)

Ridpath, J.F., Lager, K.M., Vincent, A.L., Neill, J.D., Chase, C.L., Mark, C.S. 2006. Acute BVDV infections in non-bovine species. BVDV 2006 Symposium, National Cattlemens Beef Association Annual Meeting. Paper No. 19. p. 37.

EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Proceedings)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2005. Evaluation of North American hemagglutinin subtype 1 swine influenza isolates. 40th United States-Japan Cooperative Program in Natural Resources Panel of Animal and Avian Health Meeting. p. 7.

SEROLOGIC AND PATHOGENIC EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Proceedings)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2006. Serologic and pathogenic evaluation of North American hemagglutinin subtype 1 swine influenza isolates. In: Proceedings of the American Association of Swine Veterinarians 2006 Annual Meeting, March 5-7, 2006, Kansas City, Missouri. p. 467-470.

AN INVESTIGATION OF SUSCEPTIBILITY TO PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS BETWEEN TWO GENETICALLY DIVERSE COMMERCIAL LINES OF PIGS - (Peer Reviewed Journal)

Vincent, A.L., Thacker, B.J., Halbur, P.G., Rothschild, M.F., Thacker, E.L. 2006. An investigation of susceptibility to porcine reproductive and respiratory syndrome virus between two genetically diverse commercial lines of pigs. Journal of Animal Science. 84(1):49-57.

EVALUATION OF NORTH AMERICAN HEMAGGLUTININ SUBTYPE 1 SWINE INFLUENZA ISOLATES - (Abstract Only)

Vincent, A.L., Lekcharoensuk, P., Ma, W., Gramer, M., Richt, J.A., Lager, K.M. 2005. Evaluation of North American hemagglutinin subtype 1 swine influenza isolates [abstract]. International Congress of Virology. p. 44.

ESTABLISHMENT OF A PIG MODEL FOR THE 1930 H1N1 SWINE INFLUENZA VIRUS AND APPLICATION OF REVERSE GENETICS - (Abstract Only)

Lekcharoensuk, P., Vincent, A.L., Lager, K.M., Solorzano, A., Garcia-Sastre, A., Richt, J.A. 2005. Establishment of a pig model for the 1930 H1N1 swine influenza virus and application of reverse genetics [abstract]. International Congress of Virology. p. 42.

THE IN VITRO SUSCEPTIBILITY OF MACROPHAGES TO PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VARIES BETWEEN GENETICALLY DIVERSE LINES OF PIGS - (Peer Reviewed Journal)

Vincent, A.L., Thacker, B.J., Halbur, P.G., Rothschild, M.F., Thacker, E.L. 2005. The in vitro susceptibility of macrophages to porcine reproductive and respiratory syndrome virus varies between genetically diverse lines of pigs. Viral Immunology. 18:506-512.