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United States Department of Agriculture

Agricultural Research Service

Related Topics

Nancy W Shappell
Animal Metabolism-Agricultural Chemicals Research
Research Physiologist (Animals)

Phone: (701) 239-1233
Fax: (701) 239-1430
USDA,ARS,BRL
1605 ALBRECHT BLVD N
FARGO, ND, 58102-2765

Projects
METABOLIC FATE OF CHEMICAL AND BIOLOGICAL CONTAMINANTS
Appropriated (D)
  Accession Number: 421009

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Consumption of ground beef obtained from cattle that had received steroidal growth-promotants did not trigger early onset of estrus in pre-pubertal pigs - (Peer Reviewed Journal) - (28-Aug-14)
Potential bioactivity and association of 17ß-estradiol with the dissolved and colloidal fractions of manure and soil Reprint Icon - (Peer Reviewed Journal)
Chambers, K.B., Casey, F.X., Hakk, H., Desutter, T.M., Shappell, N.W. 2014. Potential bioactivity and association of 17ß-estradiol with the dissolved and colloidal fractions of manure and soil. Science of the Total Environment. 494/495:58-64.
Modulation of estrogenic effects by environmental temperature and food availability - (Abstract Only)
Feifarek, D.J., Shappell, N.W., Schoenfuss, H.L. 2014. Modulation of estrogenic effects by environmental temperature and food availability [abstract]. 4th International Conference on Occurrence, Fate, Effects, and Analysis of Emerging Contaminants in the Environment, August 19-22, 2014, Iowa City, IA. Presented in Effects - III module: 9:45-10:00 a.m..
Modulation of estrogenic effects by environmental temperature and food availability - (Abstract Only)
Feifarek, D.J., Shappell, N.W., Schoenfuss, H.L. 2014. Modulation of estrogenic effects by environmental temperature and food availability [abstract]. Midwest Regional Society of Environmental Toxicology and Chemistry, March 24-25, 2014, Chicago, IL. p. 13.
Modulation of estrogenic exposure effects mediated through temperature and dietary regimens in male fat head minnows - (Abstract Only) - (28-Jun-13)
Serum estrogenicity and biological responses in African catfish raised in wastewater ponds in Ghana - (Peer Reviewed Journal)
Asem-Hiablie, S., Church, C., Elliott, H.A., Shappell, N.W., Schoenfuss, H.L., Drechsel, P., Williams, C.F., Knopf, A.L., Dabie, M.Y. 2013. Serum estrogenicity and biological responses in African catfish raised in wastewater ponds in Ghana. Science of the Total Environment. 463-464. p.1182-1191.
E-Screen - potential tool for assessment of relative serum estrogenicity - (Abstract Only) - (17-Mar-13)
Bioassay of estrogenicity and chemical analysis of estrogens in streams across the United States associated with livestock operations Reprint Icon - (Peer Reviewed Journal)
Alvarez, D.A., Shappell, N.W., Billey, L.O., Bermudez, D.S., Wilson, V.S., Kolpin, D.W., Perkins, S.D., Evans, N., Foreman, W.T., Gray, J.L., Shipitalo, M.J., Meyer, M.T. 2013. Bioassay of estrogenicity and chemical analysis of estrogens in streams across the United States associated with livestock operations. Water Research. 47:3347-3363.
Egg wash wastewater: Estrogenic risk or environmental asset? Reprint Icon - (Peer Reviewed Journal)
Shappell, N.W. 2013. Egg wash wastewater: Estrogenic risk or environmental asset? Integrated Environmental Assessment and Management. 9(3):517-523.
Consumption of beef from cattle administered estrogenic growth promotants does not result in premature puberty and obesity using the swine model - (Proceedings)
Magolski, J.D., Anderson, G., Shappell, N.W., Vonnahme, K.A., Berg, E.P. 2012. Consumption of beef from cattle administered estogenic growth promotants does not result in premature puberty and obesity using the swine model. Proceedings 58th International Congress of Meat Science & Technology, August 12-17, 2012, Montreal, Canada. 58:D85.
Evaluation of surface waters associated with animal feeding operations for estrogenic chemicals and activity - (Abstract Only)
Shappell, N.W., Alvarez, D., Kolpin, D., Forman, W., Gray, J., Meyer, M. 2012. Evaluation of surface waters associated with animal feeding operations for estrogenic chemicals and activity. Society of Environmental Toxicology and Chemistry North American 33rd Annual Meeting, November 11-15, 2012, Long Beach, CA. p. 377.
E-Screen evaluation of sugar beet feedstuffs in a case of reduced embryo transfer efficiencies in cattle: the role of phytoestrogens and zearalenone - (Peer Reviewed Journal)
Shappell, N.W., Mostrom, M.S., Lenneman, E.M. 2012. E-Screen evaluation of sugar beet feedstuffs in a case of reduced embryo transfer efficiencies in cattle: the role of phytoestrogens and zearalenone. In Vitro Cellular and Developmental Biology - Animals. 48:216-228.
Comparing biological effects and potencies of estrone and 17 B-estradiol in mature fathead minnows, Pimephales promelas - (Peer Reviewed Journal)
Dammann, A.A., Shappell, N.W., Bartell, S.E., Schoenfuss, H.L. 2011. Comparing biological effects and potencies of estrone and 17 B-estradiol in mature fathead minnows, Pimephales promelas. Aquatic Toxicology. 105:559-568.
Estrogenic activity – a frame of reference for some foods, agricultural wastewaters, and animal feedstuffs. - (Abstract Only)
Shappell, N.W. 2011. Estrogenic activity – a frame of reference for some foods, agricultural wastewaters, and animal feedstuffs. Society of Environmental Toxicology and Chemistry North America 32nd Annual Meeting, November 13-17, 2011, Boston, MA. Abstract 302. p. 70.
In vivo and in vitro estrogenicity and GC/MS/MS and LC/MS/MS quantification of estrogens in aqueous mixtures of raw and pelletized poultry litter - (Abstract Only)
Yonkos, L.T., Fisher, D.J., Friedel, E.A., Wilson, V.S., Hutchins, S.R., Lazorchak, J.M., Reddy, T.V., Shappell, N.W., Van Veld, P.A., Hale, R.C. 2011. In vivo and in vitro estrogenicity and GC/MS/MS and LC/MS/MS quantification of estrogens in aqueous mixtures of raw and pelletized poultry litter. Society of Environmental Toxicology and Chemistry North America 32nd Annual Meeting, November 13-17, 2011, Boston, MA. abstr. 17, p. 8.
Estrogenicity of sugar beet by-products used as animal feeds - (Abstract Only)
Shappell, N.W., Lenneman, E.M., Mostrom, M.S. 2011. Estrogenicity of sugar beet by-products used as animal feeds [abstract]. American Society of Animal Science and American Diary Science Association, July 10-14, 2011, New Orleans, LA. p. 252.
Comparing biological effects of estrone (E1) and 17ß-estradiol (E2) in mature fathead minnows - (Abstract Only)
Dammann, A.A., Shappell, N.W., Billey, L.O., Bartell, S.E., Schoenfuss, H.L. 2011. Comparing biological effects of estrone (E1) and 17B-estradiol (E2) in mature fathead minnows. Joint Meeting of the Midwest Society of Environmental Toxicology and Chemistry and the Chicago Regional Chapter of Society for Risk Analysis, March 23-24, 2011, Lake Geneva, WI.
Estrogenicity of agricultural by-products - (Abstract Only)
Lenneman, E.M., Shappell, N.W. 2011. Estrogenicity of agricultural by-products. Joint Meeting of the Midwest Society of Environmental Toxicology and Chemistry and the Chicago Regional Chapter of Society for Risk Analysis, March 23-24, 2011, Lake Geneva, WI.
Effects of liquid swine manure on dissipation of 17ß-estradiol in soil Reprint Icon - (Peer Reviewed Journal)
Zitnick, K.K., Shappell, N.W., Hakk, H., DeSutter, T.M., Khan, E., Casey, F.X.M. 2011. Effects of liquid swine manure on dissipation of 17ß-estradiol in soil. Journal of Hazardous Materials. 186:1111-1117.
Nutrient and Estrogenic Activity of Runoff Post–Application of Animal Waste-Based Fertilizer to Frozen Fields - (Abstract Only)
Shappell, N.W., Owens, L.B., Shipitalo, M.J. 2010. Nutrient and estrogenic activity of runoff post–application of animal waste-based fertilizer to frozen fields. In: 2010 Portland SETAC North America 31st Annual Meeting Abstract Book. Presentation 372, Page 88.
Comparative Biological Effects and Potency of 17a- and 17ß-Estradiol In Fathead Minnows Reprint Icon - (Peer Reviewed Journal)
Shappell, N.W., Hyndman, K., Bartell, S.E., Schoenfuss, H. 2010. Comparative biological effects and potency of 17a- and 17ß-estradiol in fathead minnows. Aquatic Toxicology. 100:1-8. DOI:10.1016/j.aquatox.2010.07.005.
Estrogenic Activity in Runoff – Effect of Animal Waste-Based Fertilizer Application to Frozen Fields - (Abstract Only)
Billey, L.O., Shipitalo, M.J., Owens, L.B., Shappell, N.W. 2010. Estrogenic activity in runoff – effect of animal waste-based fertilizer application to frozen fields. Midwest Chapter Society of Environmental Toxicology and Chemistry Abstracts, March 24-26, 2010, St. Paul, MN. Available:http://www.midwestsetac.org/2010%20abstracts/Estrogenic%20activity%20in%20runoff%20–%20effect%20of%20animal%20waste-based%20fertilizer%20application%20to%20frozen%fields, %20Billey.pdf.
Estrogenicity and Nutrient Concentration of Surface Waters Surrounding a Large Confinement Dairy Operation Using Best Management Practices for Land Application of Animal Wastes Reprint Icon - (Peer Reviewed Journal)
Shappell, N.W., Elder, K.H., West, M.S. 2010. Estrogenicity and Nutrient Concentration of Surface Waters Surrounding a Large Confinement Dairy Operation Using Best Management Practices for Land Application of Animal Wastes. Environmental Science and Technology. 44:2365-2371.
Cytochrome P450 Expression Profile of the PICM-19H Pig Liver Cell Line: Potential Application to Rapid Liver Toxicity Assays. - (Peer Reviewed Journal)
Willard, R.R., Shappell, N.W., Meekin, J.H., Talbot, N.C., Caperna, T.J. 2009. Cytochrome P450 expression erofile of the PICM-19H pig liver cell line: Potential application to rapid liver toxicity assays. In Vitro Cellular and Developmental Biology - Animals. 46(1):11-19.
Residue and Food Safety Research at the USDA ARS Animal Metabolism Research Unit - (Abstract Only)
Smith, D.J., Huwe, J.K., Hakk, H., Shappell, N.W., Shelver, W.L. 2009. Residue and Food Safety Research at the USDA ARS Animal Metabolism Research Unit. In: Proceedings of 4th International Symposium on Recent Advances in Food Analysis, November 4-6, 2009, Prague, Czech Republic. Poster A-54, page 33.
Food Safety Research at USDA: Hormones in Water and POPs in Food - (Abstract Only)
Huwe, J.K., Shappell, N.W. 2009. Food Safety Research at USDA: Hormones in Water and POPs in Food. In: Proceedings of 4th International Symposium on Recent Advances in Food Analysis, November 4-6, 2009, Prague, Czech Republic. Presentation LS2, page 11.
Estrogenic Activity and Estrogens of Surface Waters in Proximity to a Large Dairy - (Abstract Only)
Shappell, N.W., Billey, L.O., Elder, K.H. 2009. Estrogenic Activity and Estrogens of Surface Waters in Proximity to a Large Dairy. Society of Environmental Toxicology and Chemistry (SETAC)Abstract Book, New Orleans, LA, November 19-23, 2009. Abstract 31, page 11.
Effects of liquid swine manure on sorption of 17ß-estradiol to soil - (Abstract Only)
Zitnick, K., Hakk, H., Shappell, N.W., Desutter, T., Casey, F.S., Khan, E. 2009. Effects of liquid swine manure on sorption of 17ß-estradiol to soil. ASA-CSSA-SSSA Annual Meeting, November 1-5, 2009, Pittsburgh, PA. Abstract #52904. Available http://a-c-s.confex.com/crops/ 2009am/webprogram/Paper52904.html.
Development of multi-residue sulfonamide analysis using LC-MS/MS for detection in wastewater and river samples - (Abstract Only)
Shelver, W.L., Shappell, N.W. 2008. Development of Multi-residue Sulfonamide Analysis Using LC-MS/MS for Detection in Wastewater and River Samples [Abstract]. Society of Environmental Toxicology and Chemistry (SETAC) 29th Annual Meeting Abstract Book, November 16-20, 2008, Tampla, FL. RP117, page 325.
Elisa for Sulfonamides and Its Application for Screening in Water Contamination - (Peer Reviewed Journal)
Shelver, W.L., Shappell, N.W., Franek, M., Rubio, F.R. 2008. ELISA for sulfonamides and its application for screening in water contamination. Journal of Agricultural and Food Chemistry 56:6609-6615.
Comment on extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities - (Other)
Shappell, N.W. 2008. Comment on extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. Journal of Agricultural and Food Chemistry 56:3427.
Destruction of estrogens using Fe-TAML/peroxide catalysis - (Peer Reviewed Journal)
Shappell, N.W., Vrabel, M.A., Madsen, P.J., Harrington, G.E., Billey, L.O., Hakk, H., Larsen, G.L., Beach, E.S., Horwitz, C.P., Ro, K.S., Hunt, P.G., Collins, T.J. 2008. Destruction of estrogens using Fe-TAML/peroxide catalysis. Environmental Science and Technology 42:1296-1300.
Coupling LC MS-MS analysis of estrogens with E-Screen bioassay in the evaluation of agricultural wastewater - (Abstract Only)
Shappell, N.W. 2007. Coupling LC MS-MS analysis of estrogens with E-Screen bioassay in the evaluation of agricultural wastewater. Meeting Abstract. 121st AOAC Annual Meeting & Exposition, Sept. 16-20, 2007, Anaheim, CA.
Swine lagoon wastewater treatment in marsh-pond/floating wetland-marsh constructed wetland Reprint Icon - (Proceedings)
Hunt, P.G., Poach, M.E., Shappell, N.W., Matheny, T.A., Reddy, G.B., Ro, K.S., Szogi, A.A. 2007. Swine lagoon wastewater treatment in marsh-pond/floating wetland-marsh constructed wetland. In: International Symposium on Air Quality and Waste Management for Agriculture, 16-19 September, Broomfield, Colorado. 7 p. 2007 CDROM.
Tissue Residues, Metabolism, and Excretion of Na[36cl]o3 in Rats - (Peer Reviewed Journal)
Hakk, H., Smith, D.J., Shappell, N.W. 2007. Tissue residues, metabolism, and excretion of Na[36Cl]O3 in rats. Journal of Agricultural and Food Chemistry 55:2034-2042.
Estrogenic Activity and Steroid Hormones in Swine Wastewater Processed Through a Lagoon Constructed-Wetland System. - (Peer Reviewed Journal)
Shappell, N.W., Billey, L.O., Forbes, D., Poach, M.E., Matheny, T.A., Reddy, G.B., Hunt, P.G. 2007. Estrogenic activity and steroid hormones in swine wastewater processed through a lagoon constructed-wetland system.. Environmental Science and Technology 41(2):444-450.
Degradation of Estradiol and Ethinylestradiol with Taml Oxidant Activator and Hydrogen Peroxide. - (Abstract Only)
Shappell, N.W., Ro, K.S., Madsen, P., Horowitz, C., Hunt, P.G., Collins, T.J., Vrabel, M. 2006. Degradation of estradiol and ethinylestradiol with taml oxidant activator and hydrogen peroxide. Meeting Abstract. 10th Annual Green Chemistry & Engineering Conference, Washington, DC, June 26-30, 2006.
Estrogenic Activity in the Environment: Municipal Wastewater Effluent, River, Ponds and Wetlands. - (Peer Reviewed Journal)
Shappell, N.W. 2006. Estrogenic activity in the environment: municipal wastewater effluent, river, ponds and wetlands. Journal of Environmental Quality 35:122-132.
Ergovaline Movement Across Caco-2 Cells. - (Peer Reviewed Journal)
Shappell, N.W., Smith, D.J. 2005. Ergovaline movement across CACO-2 cells. In Vitro Cellular and Developmental Biology - Animals 41:245-251.
Estrogenic Activity of Swine Wastewater Treated by a Lagoon Constructed Wetland System. - (Abstract Only)
Shappell, N.W., Billey, L.O., Poach, M.E., Matheny, T.A., Reddy, G.B., Hunt, P.G. 2005. Estrogenic activity of swine wastewater treated by a lagoon constructed wetland system. SETAC North American 26th Annual Conference, Baltimore, MD, Nov. 13-17, 2005.
Fate and Transport of Sex Hormones from Poultry Litter Applied to Till and No-Till Cropping Systems - (Abstract Only)
Jenkins, M., Endale, D.M., Schomberg, H.H., Sangsupan, H.A., Radcliffe, D.R., Hartel, P.G., Cabrera, M.L., Vencill, W.K., Shappell, N.W. 2004. Fate and transport of sex hormones from poultry litter applied to till- and no-till cropping systems [abstract]. American Society of Agronomy, Agronomy Abstracts. p. 339. CDROM.
Tillage and N-Fertilizer Source Effects on Yield and Water Quality in a Corn-Rye System - (Proceedings)
Endale, D.M., Schomberg, H.H., Jenkins, M., Cabrera, M.L., Radcliffe, D.R., Hartel, P.G., Shappell, N.W. 2004. Tillage and N-fertilizer source effects on yield and water quality in a corn-rye system. Annual Southern Conservation Tillage Conference for Sustainable Agriculture. p. 37-48. CDROM. Raleigh, North Carolina.
Ergovaline Transport Across Human Gastrointestinal Cells (Caco-2). - (Abstract Only)
Shappell, N.W., Smith, D.J. 2004. Ergovaline transport across human gastrointestinal cells (caco-2). [abstract] Joint Meeting of American Society of Animal Science, American Dairy Science Association, and Poultry Science Association, St. Louis, MO, July 25-29, 2004, Journal of Animal Science 82(Suppl 1):181, Abstract T71.
Assessment of Tasco and Ycwp on Ergovaline Toxicity in Caco-2 Cells. - (Abstract Only)
Shappell, N.W., Billey, L.O. 2004. Assessment of tasco and ycwp on ergovaline toxicity in caco-2 cells. [abstract] Joint Meeting of American Society of Animal Science, American Dairy Science Association, and Poultry Science Association, St. Louis, MO, July 25-29, 2004, Journal of Animal Science 82(Suppl 1):181, Abstract T72.
Ergovaline Toxicity on Caco-2 Cells As Assessed by Mtt, Almar Blue, and DNA Assay. - (Peer Reviewed Journal)
Shappell, N.W. 2003. Ergovaline toxicity on Caco-2 cells as assessed by MTT, alamarBlue, and DNA assay. In Vitro Cellular and Developmental Biology-Animal. 39:329-335.
Assessment of Estrogenic Activity and Toxicity of Red River Water. - (Abstract Only)
Shappell, N.W. 2003. Assessment of estrogenic activity and toxicity of Red River water. [abstract]. 1st International Water Conference, Water Science & Decision-Making, April 23-24, 2003, Moorhead, MN.
Decay of Estrogenic Activity in Municipal Wastewater Lagoons. - (Abstract Only)
Shappell, N.W. 2003. Decay of estrogenic activity in municipal wastewater lagoons. Society of Environmental Toxicology and Chemistry Asia/Pacific & Australasian Society for Ecotoxicology Meeting, Sept. 28-Oct. 2, 2003, Christchurch, New Zealand.
Comparative Metabolism of Chrysene and 5-Methylchrysene by Rainbow Trout and Rat Liver Microsomes - (Peer Reviewed Journal)
Shappell, N.W., Carlino-Macdonald, U., Amin, S., Kumar, S., Sikka, H.C. 2003. Comparative metabolism of chrysene and 5-methylchrysene by rainbow trout and rat liver microsomes. Toxicological Sciences. 72:260-266.
Technical Note: Eperimerization of Ergopeptine Alkaloids in Organic and Aqueous Solvents. - (Peer Reviewed Journal)
Smith, D.J. and Shappell, N.W. 2002. Technical note: eperimerization of ergopeptine alkaloids in organic and aqueous solvents. Journal of Animal Science 80:1616-1622.
Malformation, Mortality and Parasites in Northern Leopard Frogs in MN and Nd. - (Abstract Only)
Shappell, N.W., Gackle, N.J., Canfield, J., Sutherland, D. 2002. Malformation, mortality and parasites in northern leopard frogs in MN and ND. [abstract]. Minnesota Water 2002 Conference, April 17-20, 2002, St. Cloud, MN.
Malformation Versus Mortality, a Study of Northern Leopard Frog Development in Situ. - (Abstract Only)
Shappell, N.W., Garber, E.A., Gackle, N.J., Canfield, J., Larsen, G.L. 2002. Malformation versus mortality, a study of northern leopard frog development in situ. [abstract]. Minnesota Water 2002 Conference, April 17-20, 2002, St. Cloud, MN.
Toxicity of Ergovaline on Caco2 Cells As Assessed by Mtt, Alarmarblue, and DNA Analysis. - (Abstract Only)
Shappell, N.W. 2002. Toxicity of ergovaline on Caco2 cells as assessed by MTT, alarmarBlue, and DNA analysis. [abstract]. Journal of Animal Science. 80(Suppl 1):30.
Effect of Clenbuterol on Body Stores of Polychlorinated Dibenzofurans (Pcdfs) and Dibenzo-P-Dioxins (Pcdds) in Rats - (Peer Reviewed Journal)
Shappell, N.W., Billey, L.O., Feil, V.J. 2002. Effect of clenbuterol on body stores of polychlorinated dibenzofurans (PCDFs) and dibenzo-p-dioxins (PCDDs) in rats. Journal of Animal Science. 80:2461-2475.
Malformation Versus Mortality, a Study of Northern Leopard Frog Development in Situ. - (Abstract Only)
Shappell, N.W., Garber, E., Gackle, N.J., Canfield, J., Larsen, G.L. 2002. Malformation versus mortality, a study of northern leopard frog development in situ. [abstract]. Minnesota Water 2002 Conference, April 17-20, 2002, St. Cloud, MN.
Assessment of Parasite Abundance and Health of Native Frogs Relative to Surrounding Land Use in ND and Mn. - (Abstract Only)
Gackle, N.G., Shappell, N.W., Grier, J. 2002. Assessment of parasite abundance and health of native frogs relative to surrounding land use in ND and MN. [abstract]. American Society of Ichthyologists & Herpetologists, July 3-8, 2002, Kansas City, MO.
Effect of Clenbuterol on Fat Stores of Dioxins and Furans in Rats. - (Proceedings)
Shappell, N.W., Billey, L.O., Feil, V.J. 2001. Effect of clenbuterol on fat stores of dioxins and furans in rats. Organohalogen Compounds. 53:460-463.
Effect of Ractopamine on Pcna, Desmin, and Myosin Expression in C2c12 Mouse Cells. - (Abstract Only)
Shappell, N.W., Larsen, G.L. 2000. Effect of ractopamine on PCNA, desmin, and myosin expression in C2C12 mouse cells. [abstract]. 40th Annual Meeting of the American Society of Cell Biology, Dec. 9-13, 2000, San Francisco, CA. Molecular Biology of the Cell 11(Suppl):408. Abstract No. 2119.
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Last Modified: 12/20/2014
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