(PMR) from 1994 until his retirement in August 2012. He received a B. A. and M. Sc. from Rutgers University and a Ph.D. from the University of California, Davis.
Dr. Campbell has a broad spectrum of research experience involving biochemistry, evolutionary biology and molecular biology. Dr. Campbell is currently involved in chemogenomic and chemosensitization research. The chemogenomic research is being done in collaboration with Dr. Jong H. Kim, PMR, Dr. Russell Molyneux, College of Pharmacy, Univ. of Hawaii, Dr. Jiujiang Yu, ARS Food and Feed Safety Research Unit, New Orleans, and Dr. William Nierman, at the J. Craig Venter Institute. The chemogenomic research involves the use of chemical probes to elucidate the functional genomics of mycotoxin biosynthesis. This work has led to the discovery of targeting the oxidative stress response system of fungi to inhibit mycotoxin production. The chemosensitization work is being done in collaboration with Dr. Kim, of PMR, Dr. Robert Cramer, Montana State Univ., Dr. David A. Stevens, MD, Santa Clara Valley Medical Center, Stanford Univ. School of Medicine, Dr. Greg May, MD Anderson Cancer Center, Univ. of Texas, Dr. Arunmozhi Balajee, Centers for Disease Control and Prevention, Natália Faria and Dr. Maria de Luz Martins, Institute of Hygiene and Tropical Medicine, New Univ. of Lisbon, Portugal and Drs. Larisa Scherbakova and Vitaly Dzhavakhiya, Russian Research Institute of Phytopathology (VNIIF), Moscow. This work uses safe, natural products to target fungal genes that control stress response. This targeting results in greatly heightened sensitivity to commercial fungicides and antifungal drugs, with implications for improving veterinarial and medical treatment as well as controlling agriculturally important pathogens. Drs. Campbell and Kim received the Thomas J. Walsh Clinical Mycology Award for their research on chemosensitization as the most innovative research on chemotherapy for human mycoses in 2008.
Earlier research in Dr. Campbell's career originated the concept of tri-trophic interactions. This concept brought to light possible negative consequences in the interaction between biological control and host-plant resistance in that the chemical bases of insect-plant interactions involves other trophic levels, namely insect parasitoids or symbiotic bacteria. Later, with Dr. David Dreyer (ARS retired), he discovered structural differences in plant matrix heteropolysaccharides (e.g., pectins) affect host-plant recognition and feeding behavior by aphids. Dr. Campbell was also in the forefront of using molecular phylogenetic tools, based on DNA and RNA secondary structure, to infer evolutionary relationships among insects; including Hemiptera, with Drs. Thierry Bourgoin and David Ouvrard at the Museum national d'Histoire naturelle (MNHN), Paris, France, and Chalcidoidea, with Dr. John Heraty, University of California, Riverside.
Dr. Campbell has supervised the research of nine post-doctoral research associates, two Ph.D. students from the University of California, Berkeley, and Univ. of Oulu, Finland, Masters students from Northeastern Univ., the New Univ. of Lisbon and Univ. of Rome "La Sapienza" and a diplôme d'études approfondies and Ph. D. student from MNHN. In his lab, he has hosted visiting scholars from the Chinese Academy of Sciences, Univ. of Oulu, ARRIP and MNHN. Dr. Campbell was Adjunct Professor to the Univ. of California, Berkeley and Scientific Officer for the Office of Scientific Quality Review in charge of peer-review of all ARS research projects. He is a Fellow of the American Association for the Advancement of Science and currently has >100 senior and co-authored publications as peer-reviewed journal papers and book chapters. He is currently an Associate Editor for Frontiers in Microbiology.
2013
Kim, J. H., Campbell, B. C., Chan, K. L., Mahoney, N., Haff, R.P. 2013. Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid. Molecules. 18(2): 1564-1581. [PDF reprint]
2012
Kim, J. H., Chang, P.-K., Chan, K. L., Faria, N. C. G., Mahoney, N., Kim, Y. K., Martins, M. de L., Campbell, B. C. 2012. Enhancement of commercial antifungal agents by kojic acid. Int. J. Mol. Sci. 13(11):13867-13880. [PDF reprint]
Kim, J. H., Faria, N. C. G., Martins, M. de L., Chan, K. L., Campbell, B. C.* 2012. Enhancement of antimycotic activity of amphotericin B by targeting the oxidative stress response of Candida and Cryptococcus with natural dihydroxybenzaldehydes. Front. Microbio. 3: 261. DOI:10.3389/fmicb2012.00261.
Campbell, B. C.*, Chan, K. L., Kim, J. H. 2012. Chemosensitization as a means to augment commercial antifungal agents. Front. Microbio. 3: 79. DOI:10.3389/fmicb2012.00079.
Dzhavakhiya, V., Scherbakova, L., Semina, Y., Zhemchuzhina, N., Campbell, B. 2012. Chemosensitization of plant pathogenic fungi to agricultural fungicides. Front. Microbio. 3: 87. DOI:10.3389/fmicb2012.00087.
Kim, J. H., Chan, K. L., Faria, N. C. G., Martins, M. de L., Campbell, B. C.* 2012. Targeting the oxidative stress response system of fungi with safe, redox-potent chemosensitizing agents. Front. Microbio. 3: 88. DOI:10.3389/fmicb2012.00088.
2011
Chang, P.-K., Scharfenstein, L. L., Luo, M., Mahoney, N., Molyneux, R. J., Yu, J., Brown, R. L., Campbell, B. C. 2011. Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid. Toxins 3(1): 82-104. [PDF reprint]
Faria, N. C. G., Kim, J. H., Gonçalves, L. a. P., Martins, M. de L., Chan, K. L., Campbell, B. C.* 2011. Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus. Lett. Appl. Microbiol. 52(5): 506-513. [PDF reprint]
Kim, J. H. and Campbell, B. C.* 2011. Chemogenomic analysis of fungal stress-response systems using phytochemicals. In: Pirttilä, A. M. and Sorvari, S. (eds.). Prospects and Applications for Plant-Associated Microbes, A Laboratory Manual, Part B: Fungi. pp. 80-87. BioBien Innovations. Paimio, Finland. 328 pp.
Kim, J. H. and Campbell, B. C.* 2011. Chemosensitization of fungal pathogens to antimicrobial agents using phenolic compounds. In: Pirttilä, A. M. and Sorvari, S. (eds.). Prospects and Applications for Plant-Associated Microbes, A Laboratory Manual, Part B: Fungi. pp. 212-214. BioBien Innovations. Paimio, Finland. 328 pp.
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., and Molyneux, R. J. 2011. Chemosensitization of aflatoxigenic fungi to antimycin A and strobilurin using salicylaldehyde, a volatile natural compound targeting cellular antioxidation system. Mycopathologia. 171(4): 291-298. [PDF reprint]
Kim, J. H., Mahoney, N., Chan, K. L., Campbell, B. C.*. 2011. Antifungal activity of redox-active benzaldehydes that target cellular antioxidation. Annals of Clinical Microbiology and Antimicrobials 10:23. DOI:10.1186/1476-0711-10-23.
2010
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J., and Xiao, C.-L. 2010. Use of chemosensitization to overcome fludioxonil-resistance in Penicillium expansum. Letters Appl. Microbiol. 51(2): 177-183. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and Balajee, A. 2010. Augmenting the activity of antifungal agents against aspergilli using structural analogues of benzoic acid as chemosensitizing agents. Fungal Biol. 114(10): 817-824. [PDF reprint]
Mahoney, N., Molyneux, R. J., Kim, J. H., Campbell, B. C., Waiss, A. C. and Hagerman, A. E. 2010. Aflatoxigenesis induced in Aspergillus flavus by oxidative stress and reduction by phenolic antioxidants from tree nuts. World Mycotoxin J. 3(1): 49-57. [PDF reprint]
Yu, J., Nierman, W. C., Bennett, J. W., Campbell, B. C., Bhatnagar, D., Cleveland, T. E. and Payne, G. A. Genetics and Genomics of Aspergillus flavus. In: Rai, M. K. (ed). Progress in Mycology. Springer Verlag. (in press). ISBN: 978-90-481-3712-1.
2009
Molyneux, R. J., Mahoney, N., Kim, J. H., and Campbell, B. C. Health aspects and antiaflatoxigenic activity of phytochemicals in tree nuts. In: Alasalvar, C. and Shahidi, F. (eds.). Tree Nuts: Composition, Phytochemicals, and Health Effects. pp. 95-107. CRC Press, Boca Raton, FL. [PDF reprint]
2008
Campbell, B. C., Kim, J. H., Yu, J., Molyneux, R. J., Mahoney, N. Palumbo, J. D., Chan, K. L., Bhatnagar, D. Cleveland, T. E. and Nierman, W. C. Natural products as tools for chemogenomic analysis of mycotoxin biosynthesis and fungal stress-response systems. In: Siantar, D. P., Trucksess, M., Scott, P. M. and Herman, E. M. (eds.). Food Contaminants: Mycotoxins and Food Allergens. Proceedings of the 232nd National Meeting of the American Chemical Society, Symposium Series No. 1001. Chapter 1. ISBN13 978-0-8412-6954-5.
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2008. Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochem. Biophys. Res. Comm. 372: 266-271. [PDF reprint]
Kim, J. H., Mahoney, N., Chan, K. L,. Molyneux, R. J. , May, G. S. and Campbell, B. C.* 2008. Chemosensitization of fungal pathogens to antimicrobial agents using benzo analogs. FEMS Microbiol. Lett. 281(1): 64-72. [PDF reprint]
Kim, J. H., Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Varga, J., Bhatnagar, D., Cleveland, T. E., Nierman, W. C. and Campbell, B. C.* 2008. Elucidation of the functional genomics of antioxidant-based inhibition of aflatoxin biosynthesis. Int. J. Food Microbiol. 122: 49-60. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C. 2008. Bioassay-directed isolation and identification of anti-aflatoxigenic constituents of walnuts. In: Colegate, S. M. and Molyneux, R. J. (eds). Bioactive Natural Products: Detection, Isolation and Structural Identification. pp. 421-437. CRC Press, Boca Raton, FL.
Yu, J., Payne, G. A., Campbell, B. C., Guo, B. Z., Cleveland, T. E., Robens, J. F., Keller, N. P., Bennett, J. W. and Nierman, W. C. 2008. Mycotoxin production and prevention of aflatoxin contamination in food and feed. In: Osmani, S. and Goldman, G. (eds). The ASPERGILLI: Genomics, Medical Aspects, Biotechnology, and Research Methods. pp. 457-472. CRC Press, Boca Raton, FL.
Yu, J., Payne, G. A., Nierman, W. C., Machida, M., Bennett, J. W., Campbell, B. C., Robens, J. F., Bhatnagar, D., Dean, R. A. and Cleveland, T. E. 2008. Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation. Food Addit. Contamin. 25(9): 1152-1157. [PDF reprint]
2007
Beck, J. J., Kim, J. H., Campbell, B. C. and Chou, S.-C. 2007. Fungicidal activities of dihydroferulic acid alkyl ester analogues. J. Nat. Prod. 70(5): 779-782. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May. G. S. 2007. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol. 45(2):134-141. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L., Molyneux, R. J. and May, G. S. 2007. Enhancement of fludioxonil fungicidal activity by disrupting cellular glutathione homeostasis with 2,5-dihydroxybenzoic acid. FEMS Microbiol. Lett. 270(2): 284-290. [PDF reprint]
Lee, S.-E., Park, B. S., Bayman, P., Baker, J. L., Choi, W. S. and Campbell, B. C. 2007. Suppression of ochratoxin biosynthesis by naturally occurring alkaloids. Food Addit. Contamin. 24(4): 391-397. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C. 2007. Mycotoxins in edible tree nuts. Int. J. Food Microbiol. 119: 72-78. [PDF reprint]
Molyneux, R. J., Mahoney, N., Kim, J. H. and Campbell, B. C. 2007. Inhibition of aflatoxin biosynthesis in Aspergillus flavus by phenolic natural products. pp. 231-251 In: Natural Products: Essential Resources for Human Survival (Zhu, Y.-Z, Tan, B. K.-H., Bay, B.-H. and Liu, C.-H., eds.) World Scientific Publishing Co., Singapore.
Yu, J., Ronning, C. M., Wilkinson, J. R., Campbell, B. C., Payne, G. A., Bhatnagar, D., Cleveland, T. E. and Nierman, W. C. 2007. Gene profiling for studying the mechanism of aflatoxin biosynthesis in Aspergillus flavus and A. parasiticus. Food Addit. Contamin. 24(10): 1035-1042. [PDF reprint]
2006
Kim, J. H., Mahoney, N., Chan, K. L., Molyneux. R. J. and Campbell, B. C.*. 2006. Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds. Appl. Microbiol. Biotechnol. 70(6): 735-739. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Yu, J., Mahoney, N., Chan, K. L., Molyneux, R. J., Bhatnagar, D. and Cleveland, T. E. 2006. High throughput genetic tool for examining effects of natural products in fungi. pp. 27-33. In: EBA 2005 Proc. 1st Intl. Conf. Plant Microbe Interactions: Endophytes and Biocontrol Agents. (Sovari, S. and Toldi, O., eds.). SaariselkÅ , Finland, 18-22 April 2005. Karhukopio OY, Turku, Finland. 176 pp.
Kim, J. H., Campbell, B. C.*, Mahoney, N., Chan, K. L. and May, G. S. 2006. Targeting antioxidative signal transduction and stress response system: Control of pathogenic Aspergillus with phenolics that inhibit mitochondrial function. J. Appl. Microbiol. 101(1): 181-189. [PDF reprint]
Kim, J. H., Campbell, B. C.*, Molyneux, R. J., Mahoney, N., Chan, K. L., Yu, J., Wilkinson, J., Cary, J., Bhatnagar, D. and Cleveland., T. E. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Research 22(1): 3-8. [PDF reprint]
Yu, J., Cleveland, T. E., Wilkinson, J. R., Campbell, B. C., Kim, J. H., Kim, H. S., Bhatnagar, D., Payne, G. A. and Nierman, W. C. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Research 22(1): 16-21. [PDF reprint]
* corresponding author
Printable Version
E-mail this page
