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United States Department of Agriculture

Agricultural Research Service

JOHN WILLIAM. NEWMAN

Research Chemist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Metabolomics: Insulin Resistance and Type 2 Diabetes Mellitus - (Book / Chapter) - (13-May-14)
A diet containing a nonfat dry milk matrix significantly alters systemic endocannabinoids and oxylipins in diet-induced obese mice - (Peer Reviewed Journal)
Dunn, T.N., Keenan, A.H., Thomas, A.P., Newman, J.W., Adams, S.H. 2014. A diet containing a nonfat dry milk matrix significantly alters systemic endocannabinoids and oxylipins in diet-induced obese mice. Nutrition and Metabolism. 11:1-12.
Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin - (Peer Reviewed Journal)
Campbell, C., Grapov, D., Fiehn, O., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Gustafson, M.B., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., W. Timothy, G., Harper, M., Hoppel, C.L., Meissen, J.K., Takeuchi, K., Adams, S.H. 2014. Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One. 9(1):e84260. DOI:10.1371/journal.pone.0084260.
Indomethacin treatment prevents diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice - (Peer Reviewed Journal)
Fjaere, E., Aune, U., Keenan, A., Ma, T., Lillefosse, H., Xi, Y., Newman, J.W., Haj, F., Liaset, B., Kristiansen, K., Madsen, L. 2014. Indomethacin treatment prevents diet-induced obesity and insulin resistance, but not glucose intolerance in C57BL/6J mice. Journal of Biological Chemistry. DOI: 10.1074/jbc.M113525220.
Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults - (Peer Reviewed Journal)
Piccolo, B.D., Dolnikowski, G., Seyoum, E., Thomas, A., Gertz, E.R., Souza, E.C., Keim, N.L., Adams, S.H., Newman, J.W., Woodhouse, L.R., Van Loan, M.D. 2013. Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults. American Journal of Clinical Nutrition. 5(9), 3352-3366. DOI:10.3390/nu5093352.
Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets - (Peer Reviewed Journal)
Bruins, M.J., Dane, A.D., Strassburg, K., Vreeken, R.J., Newman, J.W., Salem, Jr, N., Tyburczy, C., Brenna, J.T. 2013. Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. Journal of Lipid Research. 54(6):1598-1607.
Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model - (Peer Reviewed Journal)
Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2013. Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model. International Journal of Oncology. 42:741-748. DOI: 10.3892/ijo.2012.1734.
The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle - (Peer Reviewed Journal)
Fedor, D.M., Adkins, Y.C., Newman, J.W., Mackey, B.E., Kelley, D.S. 2013. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle. Metabolic Syndrome and Disorders. 11(1):63-70. DOI: 10.1089/met.2012.0116.
Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids - (Peer Reviewed Journal)
Grapov, D., Adams, S.H., Pedersen, T.L., Garvey, W.T., Lok, K.H., Newman, J.W. 2012. Type 2 diabetes associated changes in the plasma non-esterified fatty acids, oxylipins and endocannabinoids. PLoS One. 7(11):e48852.
Dietary resveratrol does not delay engraftment, sensitize to vincristine, or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice - (Peer Reviewed Journal)
Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2012. Dietary resveratrol does not delay engraftment, sensitize to vincristine, or inhibit growth of high-risk acute lymphoblastic leukemia cells in NOD/SCID mice. International Journal of Oncology. 41(6):2207-2212. DOI: 10.3892/ijo.2012.1650.
Daily consumption of orange-fleshed sweet potato with added fat tends to increase total body vitamin A pool size in vitamin A depleted Bangladeshi women - (Peer Reviewed Journal) - (09-Aug-12)
Irf-1 and Mirna126 Modulate Inflammatory Vcam-1 Expression in Response to a High Fat Meal - (Peer Reviewed Journal)
Sun, C., Alkhoury, K., Wang, Y.I., Foster, G.A., Radecke, C.E., Tam, K., Edwards, C.M., Facciotti, M.T., Armstrong, E.J., Knowlton, A.A., Newman, J.W., Passerini, A.G., Simon, S.I. 2012. IRF-1 and miRNA126 modulate inflammatory VCAM-1 expression in response to a high fat meal. Circulation Research. 111:1054-1064.
imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel - (Peer Reviewed Journal)
Grapov, D., Newman, J.W. 2012. imDEV: a graphical user interface to R multivariate analysis tools in Microsoft Excel. Oxford University Press. doi:10.1093.
Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker - (Peer Reviewed Journal)
Shahab-Ferdows, S., Anaya-Loyola, M.A., Vergara-Castaneda, H., Rosado, J., Keyes, W.R., Newman, J.W., Miller, J., Allen, L.H. 5012. Vitamin B-12 supplementation of rural Mexican women changes biochemical B-12 status indicators but does not affect hematology or a bone turnover marker. Journal of Nutrition. vol. 142, no. 10, 1881-1887.
Quantitative profiling of oxylipins through comprehensive lc-ms/ms analysis: Application in cardiac surgery - (Peer Reviewed Journal)
Strassburg, K., Pedersen, T.L., Huijbrechts, A.M., Kortekaas, K., Lindeman, J., Dane, A., Berger, R., Brenkman, A., Hankemeier, T., Van Duynhoven, J., Kalkhoven, E., Newman, J.W., Vreeken, R. 2012. Quantitative profiling of oxylipins through comprehensive lc-ms/ms analysis: Application in cardiac surgery. Analytical and Bioanalytical Chemistry. 404(5):1413-1426.
Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers - (Peer Reviewed Journal)
Keenan, A.H., Pedersen, T.L., Fillaus, K., Larson, M.K., Shearer, G.C., Newman, J.W. 2012. Basal omega-3 fatty acid status affects fatty acid and oxylipin responses to high-dose n3-HUFA in healthy volunteers. Journal of Lipid Research. doi: 10.1194.
Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans - (Peer Reviewed Journal)
Armstrong, P., Kelley, D.S., Newman, J.W., Staggers, F., Hartiala, J., Allayee, H., Stephensen, C.B. 2012. Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. Journal of Nutrition. 142(8):1417-1428. DOI: 10.3945/jn.112.159814.
Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful? - (Peer Reviewed Journal)
Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variations in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Nutrition and Metabolism. 9:26.
Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful? - (Peer Reviewed Journal)
Krishnan, S., Newman, J.W., Hembrooke, T.A., Keim, N.L. 2012. Variation in metabolic responses to meal challenges differing in glycemic index in healthy women: Is it meaningful?. Journal of Nutrition and Metabolism. 9(1):26.
Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways - (Peer Reviewed Journal)
Huang, S., Rutkowsky, J.M., Snodgrass, R.G., Ono-Moore, K., Schneider, D.A., Newman, J.W., Adams, S.H., Hwang, D.H. 2012. Saturated fatty acids activate TLR-mediated pro-inflammatory signaling pathways. Journal of Lipid Research. Epublished. DOI: 10.1194/jlr.D029546.
Resveratrol given intraperitoneally does not inhibit growth of high-risk t(4;11) acute lymphoblastic leukemia cells in NOD/SCID mouse model - (Peer Reviewed Journal)
Zunino, S.J., Storms, D.H., Newman, J.W., Pedersen, T.L., Keen, C.L., Ducore, J.M. 2012. Resveratrol given intraperitoneally does not inhibit growth of high-risk t(4;11) acute lymphoblastic leukemia cells in NOD/SCID mouse model. International Journal of Oncology. 40(4):1277-84. DOI:10.3892/IJO.2011.1316.
An optimized method for measuring methylmalonic acid in low volumes of serum using UPLC-MS/MS - (Peer Reviewed Journal)
Pedersen, T.L., Keyes, W.R., Shahab-Ferdows, S., Allen, L.H., Newman, J.W. 2011. An Optimized Method for Measuring Methylmalonic Acid in Low Volumes of Serum Using UPLC-MS/MS. Journal of Chromatography. B. 879, 1502-6.
Effects of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women Reprint Icon - (Peer Reviewed Journal)
Bendensen, N.T., Stender, S., Szecsi, P.B., Pedersen, S.B., Basu, S., Hellgren, L.I., Newman, J.W., Larsen, T.M., Haugaard, S.B., Astrup, A. 2011. Effects of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. Journal of Lipid Research. doi 10.1194/jlr.M014738.
Alox5 Gene Variants Affect Eicosanoid Production and Response to Fish Oil Supplementation Reprint Icon - (Peer Reviewed Journal)
Stephensen, C.B., Armstrong, P., Newman, J.W., Pedersen, T.L., Legault, J., Schuster, G., Kelley, D.S., Vikman, S., Hartiala, J., Hooman, A. 2011. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. Journal of Lipid Research. 52(5):991-1003.
The human serum metabolome Reprint Icon - (Peer Reviewed Journal)
Psychogios, N., Hau, D.D., Peng, J., Guo, A., Mandal, R., Bouatra, S., Sinelnikov, I., Krishnamurthy, R., Eisner, R., Gautam, B., Young, N., Xia, J., Knox, C., Dong, E., Huang, P., Hollander, Z., Pedersen, T.L., Smith, S.R., Bamforth, F., Greiner, R., Mcmanus, B., Newman, J.W., Goodfriend, T., Wishart, D.S. 2011. THE HUMAN SERUM METABOLOME. PLoS One. 6(2): e16957.
12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms Reprint Icon - (Peer Reviewed Journal)
Gertow, K., Nobili, E., Folkersen, L., Newman, J.W., Pedersen, T.L., Swedenborg, J., Paulsson-Berne, G., Kuhn, H., Hedin, U., Wheelock, C.E., Hansson, G.K., Haeggstrom, J.Z., Gabrielsen, A. 2011. 12- and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebrovascular symptoms. Atherosclerosis. 215:411-416.
Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers - (Peer Reviewed Journal)
Giordano, R.M., Newman, J.W., Pedersen, T.L., Ramos, M.I., Stebbins, C. 2011. Effects of dynamic exercise on plasma arachidonic acid epoxides and diols in human volunteers. American Journal of Clinical Nutrition. doi: 21, 471-479.
Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and Type 2 diabetic obese African-American women Reprint Icon - (Peer Reviewed Journal)
Fiehn, O., Garvey, W., Newman, J.W., Lok, K.H., Hoppel, C.L., Adams, S.H. 2010. Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women. PLoS One. Vol.5(12): e15234.
Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical activity for personalized health research Reprint Icon - (Peer Reviewed Journal)
Stumbo, P.J., Weiss, R., Newman, J.W., Pennington, J.A., Tucker, K.L., Wiesenfield, P., Illner, A., Klurfeld, D.M., Kaput, J. 2010. Web-enabled and improved software tools and data are needed to measure nutrient intakes and physical activity for personalized health research. Journal of Nutrition. 140:2104-2115.
Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study - (Peer Reviewed Journal)
Van Erk, M.J., Wopereis, S., Rubingh, C., Van Vliet, T., Verheij, E., Cnubben, N., Pedersen, T.L., Newman, J.W., Age, S., Van Der Greef, J., Hendriks, H., Van Ommen, B. 2010. Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study. Biomed Central (BMC) Genomics. 3:5.
Trans fatty acids adversely affect blood lipids but not intra-abdominal and liver fat deposition - a randomized trial in overweight postmenopausal women - (Peer Reviewed Journal)
Bendsen, N.T., Chabanova, E., Thomsen, H.S., Larsen, T.M., Newman, J.W., Stender, S., Dyerberg, J., Haugaard, S.B., Astrup, A. 2010. Trans fatty acids adversely affect blood lipids but not intra-abdominal and liver fat deposition - a randomized trial in overweight postmenopausal women. Nutrition and Diabetes. 1:e4; 10.1038.
Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters Reprint Icon - (Peer Reviewed Journal)
Shearer, G.C., Harris, W.S., Pedersen, T.L., Newman, J.W. 2010. DETECTION OF OMEGA-3 OXYLIPINS IN HUMAN PLASMA AND RESPONSE TO TREATMENT WITH OMEGA-3 ACID ETHYL ESTERS. Journal of Lipid Research. 51(8):2074-81.
Impact of circulating esterified eicosanoids and other oxylipins on endothelial function - (Peer Reviewed Journal)
Shearer, G., Newman, J.W. 2009. Impact of circulating esterified eicosanoids and other oxylipins on endothelial function. Current Atherosclerosis Reports. Vol. 11:403-410.
Increased Expression of Receptors for Orexigenic Factors in Nodose Ganglion of Diet-Induced Obese Rats Reprint Icon - (Peer Reviewed Journal)
Paulino, G., Barbier De La Serre, C., Knotts, T.A., Oort, P.J., Newman, J.W., Adams, S.H., Raybould, H. 2009. INCREASED EXPRESSION OF RECEPTORS FOR OREXIGENIC FACTORS IN NODOSE GANGLION OF DIET-INDUCED OBESE RATS. American Journal of Physiology - Endocrinology and Metabolism, 296:898-903.
Administration of a Substituted Adamantly-Urea Inhibitor of the Soluble Epoxide Hydrolase Protects the Kidney from Damage in Hypertensive Goto-Kakizaki Rats Reprint Icon - (Peer Reviewed Journal)
Olearczyk, J.J., Quigley, J.E., Mitchell, B.C., Yamamoto, T., Kim, I., Newman, J.W., Luria, A., Hammock, B.D., Imig, J.D. 2010. ADMINISTRATION OF A SUBSTITUTED ADAMANTLY-UREA INHIBITOR OF THE SOLUBLE EPOXIDE HYDROLASE PROTECTS THE KIDNEY FROM DAMAGE IN HYPERTENSIVE GOTO-KAKIZAKI RATS. Trade Journal Publication. 10.1042/CS20080039.
Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women Reprint Icon - (Peer Reviewed Journal)
Adams, S.H., Hoppel, C.L., Lok, K.H., Zhao, L., Wong, S.W., Minkler, P.E., Hwang, D.H., Newman, J.W., Garvey, W.T. 2009. Plasma Acylcarnitine Profiles Suggest Incomplete Fatty Acid ß-Oxidation and Altered Tricarboxylic Cycle Activity in Type 2 Diabetic African-American Women. Journal of Nutrition, 139:1073-1081.
Triglyceride-Rich Lipoprotein Lipolysis Releases Neutral and Oxidized Free Fatty Acids That Induce Endothelial Cell Inflammation Reprint Icon - (Peer Reviewed Journal)
Wang, L., Gill, R., Pedersen, T.L., Higgins, L.J., Newman, J.W., Rutledge, J.C. 2008. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that induce endothelial cell inflammation. Journal of Lipid Research. Papers in press published ahead of print, doi:10.1194/jlr.M700505-JLR200
Lipoprotein Lipase Releases Esterified Oxylipins from Very Low-Density Lipoproteins. Reprint Icon - (Peer Reviewed Journal)
Shearer, G.C., Newman, J.W. 2008. Lipoprotein lipase releases esterified oxylipins from very low-density lipoproteins. Prostaglandins Leukot. Essent. Fatty Acids. 79:215-222.
Phospholipase A2 Reduction Ameliorates Cognitive Deficits in Mouse Model of Alzheimer’s Disease Reprint Icon - (Peer Reviewed Journal)
Sanchez-Mejia, R.O., Newman, J.W., Toh, S., Yu, G., Zhou, Y., Scearce-Levie, K., Cheng, I.H., Gan, L., Palop, J.J., Bonventre, J.V., Mucke, L. 2008. PHOSPHOLIPASE A2 REDUCTION AMELIORATES COGNITIVE DEFICITS IN MOUSE MODEL OF ALZHEIMER’S DISEASE. Nature Neuroscience. 11(11): 1311–1318.
Isolation and characterization of a low phytic acid rice mutant reveals a mutation in the rice orthologue of maize mik. Reprint Icon - (Peer Reviewed Journal)
Kim, S., Andaya, C.B., Newman, J.W., Goyal, S.S., Tai, T. 2008. ISOLATION AND CHARACTERIZATION OF A LOW PHYTIC ACID RICE MUTANT REVEALS A MUTATION IN THE RICE ORTHOLOGUE OF MAIZE MIK. Journal of Theoretical and Applied Genetics. 117(8):1291-301.
Increased Blood Pressure in Mice Lacking Cytochrome P450 2j5 Reprint Icon - (Peer Reviewed Journal)
Athirakul, K., Bradbury, A.J., Graves, J.P., Degraff, L.M., Ma, J., Zhao, Y., Couse, J.F., Quigley, R., Harder, D.R., Zhao, X., Imig, J.D., Pedersen, T.L., Newman, J.W., Hammock, B.D., Conley, A.J., Korach, K.S., Coffman, T.M., Zeldin, D.C. 2008. INCREASED BLOOD PRESSURE IN MICE LACKING CYTOCHROME P450 2J5. Federation of American Societies for Experimental Biology Conference. 12):4096-108.
Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase - (Peer Reviewed Journal)
Morisseau, C., Newman, J.W., Wheelock, C.E., Hill, Iii, T., Morin, D., Buckpitt, A.R., Hammock, B.D. 2008. Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology. 21:951-957.
Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Reprint Icon - (Peer Reviewed Journal)
Wheelock, C.E., Forshed, J., Goto, S., Hammock, B.D., Newman, J.W. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology. 21;583-590, 2008.
Salt Loading Increases Urinary Excretion of Linoleic Acid Diols and Triols in Healthy Human Subjects - (Peer Reviewed Journal)
Driesbach, A.W., Rice, J.C., Japa, S., Newman, J.W., Sigel, A., Gill, R., Hess, A.E., Cemo, A.C., Fonseca, J.P., Hammock, B.D., Lertora, J., Hamm, J.P. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. 2008 Hypertension. 51:755-761.
Pathogenesis of Aryl Hydrocarbon Receptor-Mediated Development of Lymphoma Is Associated with Increased Cyclooxygense-2 Expression - (Peer Reviewed Journal)
Vogel, C., Li, W., Sciullo, E., Newman, J.W., Hammock, B., Reader, R.J., Tuscano, J., Matsumura, F. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygense-2 expression. 2007. American Journal of Pathology. Vol.171, No.5;1538-1548.
Clofibrate-Induced Changes in the Liver, Heart, Brain and White Adipose Lipid Metabolome of Swiss-Webster Mice. Reprint Icon - (Peer Reviewed Journal)
Wheelock, C.S., Goto, S., Hammock, B.D., Newman, J.W. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of swiss-webster mice. Metabolomics 3(2):137-145, 2007.
Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice - (Peer Reviewed Journal)
Luria, A., Weldon, S.M., Kabcenell, A.K., Ingraham, R.H., Matera, D., Jiang, H., Gill, R., Morisseau, C., Newman, J.W., Hammock, B.D. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene disrupted mice. 2007. Journal of Biological Chemistry. Vol.282,No.5:12891-2898.
Peptidyl-urea based inhibitors of soluble epoxide hydrolases - (Peer Reviewed Journal)
Norisseau, C., Newman, J.W., Tsai, H., Baecker, P.A., Hammock, B.D. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. 2006. Bioorganic and Medicinal Chemistry Letters. Vol.16: 5439-5444.
Role of Soluble Epoxide Hydrolase in Post-Ischemic Recovery of Heart Contractile Function Reprint Icon - (Peer Reviewed Journal)
Seubert, J.M., Sinal, C.J., Graves, J.P., Degraff, L.M., Bradbury, A.J., Lee, C.R., Goralski, K.B., Carey, M.A., Luria, A., Newman, J.W., Hammock, B.D., Roberts, H., Rockman, H.A., Murphy, E., Zeldin, D.C. 2006. Role of soluble epoxide hydrolase in post-ischemic recovery of heart contractile function. Journal of Clinical Investigation. 2006. 99:442-450.
Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study Reprint Icon - (Peer Reviewed Journal)
Lee, C.R., North, K.E., Bray, M.S., Fornage, M., Seubert, J.M., Newman, J.W., Hammock, B.D., Couper, D.J., Heiss, G., Zeldin, D.C. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Human Molecular Genetics. 15(10): 1640-1649, 2006.
Fatty Acid Profiles of Liver, Adipose Tissue, Spleen, and Heart of Mice Fed Diets Containing T10, C-12-, and C9, T11-Conjugated Linoleic Adic Reprint Icon - (Peer Reviewed Journal)
Kelley, D.S., Bartolini, G.L., Newman, J.W., Vemuri, M., Mackey, B.E. 2006. FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC. Prostaglandins Leukotrienes and Essential Fatty Acids. 74:331-338.
Attenuation of Vascular Smooth Muscle Cell Proliferation by 1-Cyclohexyl-3-Dodecyl Urea Is Independent of Soluble Epoxide Hydrolase Inhibition. Reprint Icon - (Peer Reviewed Journal)
Davis, B.B., Morisseau, C., Pedersen, T., Newman, J.W., Hammock, B.D., Weiss, R.H. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition.. American Society of Pharmacology and Experimental Therapeutics. 2006: Vol.316, No.2:815-821.
An Epoxide Hydrolase Inhibitor, 12-(3-Adamantan-1-Yl-Ureido) Dodecanoic Acid (Auda), Reduces Ischemic Cerebral Infarct Size in Stroke-Prone Spontaneously Hypertensive Rats. Reprint Icon - (Peer Reviewed Journal)
Dorrance, A.M., Rupp, N., Pollock, D.M., Newman, J.W., Hammock, J.D., Imig, J.D. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido) dodecanoic acid (auda), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal Cardiovasc Pharmacol. 2005; 46(6):842-848.
Lipid Sulfates and Sulfonates Are Allosteric Competitive Inhibitors of the N-Terminal Phosphatase Activity of the Mammalian Soluble Epoxide Hydrolase Reprint Icon - (Peer Reviewed Journal)
Tran, K.L., Aronov, P.A., Tanaka, H., Newman, J.W., Hammock, B.D., Morisseau, C. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the n-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Journal of Biochemistry. 44:12179-12187, 2005.
An Orally Active Epoxide Hydrolase Inhibitor Lowers Blood Pressure and Provides Renal Protection in Salt-Sensitive Hypertension - (Peer Reviewed Journal)
Imig, J.D., Zhao, X., Zaharis, C.Z., Olearczyk, J.J., Pollock, D.M., Newman, J.W., Kim, I.H., Watanabe, T., Hammock, B.D. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 2005;46(part 2):975-981.
Soluble Epoxide Hydrolase Is a Therapeutic Target for Acute Inflammation Reprint Icon - (Peer Reviewed Journal)
Schmelzer, K.R., Kubala, L., Newman, J.W., Kim, I., Eiserich, J.P., Hammock, B.D. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Journal of the National Academy of Sciences. 102,9772-9777, 2005.
The Graded Effects of Proteinuria on Hdl Structure in Nephrotic Rats Reprint Icon - (Peer Reviewed Journal)
Shearer, G.C., Newman, J.W., Hammock, B.D., Kaysen, G.A. The graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology. 16: 1309-1319, 2005.
Last Modified: 6/10/2013
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