Page Banner

United States Department of Agriculture

Agricultural Research Service

Related Topics

Thomas Ty Wang (Tom)
Diet, Genomics and Immunology Laboratory
Chemistry

Phone: (301) 504-8459 ext. 239
Fax: (304) 504-9062

Room 132
10300 BALTIMORE AVE
BLDG 307-C BARC-EAST
BELTSVILLE , MD 207052350

Projects
Regulatory Mechanisms Induced by Health-Promoting Bioactive Food Components on Sex Steroid Hormone-Dependent Pathways, Cancer Cell-Stromal Cell Interactions, and the Gut Microbiome
Appropriated (D)
  Accession Number: 426494
John A. Milner Fellowship Program
Interagency Reimbursable Agreement (I)
  Accession Number: 428527
Study of Nutrient Gene Interactions (Erx/AhR)2/3
Interagency Reimbursable Agreement (I)
  Accession Number: 427257
Nutrient Gene Interaction in Prostate Cancer Cells: Effects of I3C/DIM on AhR-Mediated Pathway
Interagency Reimbursable Agreement (I)
  Accession Number: 431013
Research Partnership with Howard University
Nonfunded Cooperative Agreement (N)
  Accession Number: 427623
Investigation on Phytochemical and Macronutrient Properties of Soybeans Grown in Romania
Nonfunded Cooperative Agreement (N)
  Accession Number: 429701
Research Partnership with the University of the District of Columbia
Nonfunded Cooperative Agreement (N)
  Accession Number: 427121
Research Partnership with Old Dominion University
Nonfunded Cooperative Agreement (N)
  Accession Number: 426389
Research Partnership with Konkuk University Division of Food and Bioscience (KKU)
Nonfunded Cooperative Agreement (N)
  Accession Number: 426462
Research Partnership with Shanghai Jiao Tong University
Nonfunded Cooperative Agreement (N)
  Accession Number: 426471
Cross-Kingdom Regulation Between Dietary Small RNAs and Human Gut Microbiome, and Its Influence on Human Health
Specific Cooperative Agreement (S)
  Accession Number: 428823
Metabolic Effects of Prenatal Exposure to Particulate Matter
Specific Cooperative Agreement (S)
  Accession Number: 428958
Studies on the Effects of Dietary Bioactive Components on Chronic Disease Prevention
Specific Cooperative Agreement (S)
  Accession Number: 429208
Dietary Small RNAs, the Human Gut Microbiome, and Influence on Human Health
Specific Cooperative Agreement (S)
  Accession Number: 429362
Diet Induced Changes in Gene Interactions in Cancer Cells
Specific Cooperative Agreement (S)
  Accession Number: 421966

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice -
Liu, M., Liu, J., Wu, Y., Gao, B., Wu, P., Shi, H., Sun, X., Huang, H., Wang, T.T., Yu, L. 2016. Preparation of five 3-MCPD fatty acid esters and the effects of their chemical structures on acute oral toxicity in Swiss mice. Journal of Food Chemistry. doi: 10.1002/jsfa.7805.
Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties -
Liu, J., Li, Y., Haiming, S., Wang, T.T., Wu, X., Sun, X., Yu, L. 2016. Components characterization of total tetraploid jiaogulan (Gynostemma pentaphylla) saponin and its cholesterol-lowering properties. Journal of Functional Foods. 23: 542-555.
3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway -
Liu, M., Huang, G., Wang, T.T., Sun, X., Yu, L. 2016. 3-MCPD 1-palmitate induced renal tubular cell apoptosis in vivo via JNK/p53 pathway. Toxicological Sciences. 151(1):181-92. doi: 10.1093/toxsci/lfw033.
Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model -
Huang, H., Xie, Z., Yokoyama, W.H., Yu, L., Wang, T.T. 2016. Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model. Journal of Nutritional Science. doi: 10.1017/jns.2016.3eCollection2016.
An effective and simple procedure to isolate abundant quantities of biologically active chemopreventive lunasin-protease inhibitor concentrate (LPIC) from soybean Reprint Icon -
Krishnan, H.B., Wang, T.T. 2015. An effective and simple procedure to isolate abundant quantities of biologically active chemopreventive lunasin-protease inhibitor concentrate (LPIC) from soybean. Food Chemistry. 177:120-126.
The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate -
Luo, Y., Teng, Z., Wang, T.T., Wang, Q. 2013. The cellular uptake and transport of zein nanoparticles: Effect of sodium caseinate. Journal of Agricultural and Food Chemistry. 61(31):7621-9.
Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages -
Trasino, S.E., Dawson, H.D., Urban Jr, J.F., Wang, T.T., Solano Aguilar, G. 2013. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. Journal of Nutritional Biochemistry. 24(11):1931-1939.
Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model -
Huang, H., Xie, Z., Boue, S.M., Bhatnagar, D., Yokoyama, W.H., Yu, L.L., Wang, T.T. 2013. Cholesterol-lowering activity of soy-derived glyceollins in the golden Syrian hamster model. Journal of Agricultural and Food Chemistry. 61(24):35772-5782.
Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells -
Kim, E.K., Kim, Y.S., Milner, J.A., Wang, T.T. 2013. Indole-3-carbinol and 3’, 3’-diindolylmethane modulate androgen effect up-regulation on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells. Cancer Prevention Research. 6(6):519-529.
Development and application of nanoparticles synthesized with folic acid-conjugated soy protein -
Teng, Z., Luo, Y., Wang, T.T., Zanh, B., Wang, Q. 2013. Development and application of nanoparticles synthesized with folic acid-conjugated soy protein. Journal of Agricultural and Food Chemistry. 61(10):2556-64.
Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability -
Lou, Y., Wang, T.T., Teng, Z., Chen, P., Sun, J., Wang, Q. 2013. Encapsulation of indole-3-carbinol and 3'3'-diindolylmethane in zein/carboxymethyl chitosan nanoparticles with controlled release property and improved stability. Food Chemistry. 139(1-4):224-30.
Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms -
Wang, T.T., Edwards, A.J., Clevidence, B.A. 2013. Strong and weak plasma response to dietary carotenoids identified by cluster analysis and linked to beta-carotene 15,15'-monooxygenase 1 single nucleotide polymorphisms. Journal of Nutritional Biochemistry. 24(8):1538-1546.
Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes -
Huang, H., Fletcher, A., Niu, Y., Wang, T.T., Yu, L. 2012. Characterization of lipopolysaccharide-stimulated cytokine expression in macrophages and monocytes. Inflammation Research. 61(12):1329-1338.
Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance -
Park, J.B., Wang, T.T. 2012. Safflomide increases the expression of adiponectin in vitro and in vivo: Implication for hypoadiponectemia, visceral obesity, and insulin resistance. Journal of Agricultural and Food Chemistry. 25(60):4048-52.
Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent -
Palavalli, M.H., Natarajan, S.S., Wang, T.T., Krishnan, H.B. 2012. Inhibition of soybean seeds in warm water results in the release of copious amounts of Bowman-Birk protease inhibitor, a putative anticarcinogenic agent. Journal of Agricultural and Food Chemistry. 60:3135-3143.
Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP -
Wang, T.T., Schoene, N.W., Kim, E.K., Kim, Y.S. 2012. Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in the androgen-responsive prostate cancer cell LNCaP. Molecular Carcinogenesis. DOI:10.1002/mc.21906.
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate -
Li, R.W., Li, C., Wang, T.T. 2012. Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanate. Molecular Carcinogenesis. DOI: 10.1002/mc.21873.
The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways -
Wang, T.T., Boue, S.M., Krishnan, H.B. 2011. The protective effect of soybean phytochemicals on androgen responsive human prostate cancer cells LNCaP is likely mediated through modulation of hormone/cytokine-dependent pathways. Functional Foods in Health and Disease. 1(11):457-471.
Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum -
Xie, Z., Huang, H., Zhao, Y., Shi,, H., Wang, S., Wang, T.T., Chen, P., Yu, L. 2011. Chemical composition, and anti-proliferative and anti-inflammatory effects of the leaf and wholeplant samples of diploid and tetraploid gynostemma pentaphyllum. Food Chemistry. 132:125-133.
A role for p53 in selenium-induced senescence -
Wu, M., Wu, R., Wang, T.T., Cheng, W. 2011. A role for p53 in selenium-induced senescence. Journal of Agricultural and Food Chemistry. 591:1182-1187.
Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis -
Hudson, T., Perkins, S., Hursting, S., Young, H., Kim, Y., Wang, T., Wang, T.T. 2011. Dietary phenethyl isothiocyanate inhibition of androgen-responsive LNCaP prostate cancer cell tumor growth correlates with decreased angiogenesis. International Journal of Oncology. 40:1113-1121.
Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties -
Huang, H., Cheng, Z., Shi, H., Xin, W., Wang, T.T., Yu, L. 2011. Isolation and characterization of two flavonoids, engeletin and astilbin, from the leaves of Engelhardia roxburghiana, and their potential anti-inflammatory properties. Journal of Agricultural & Food Chemistry. 59(9):4562-9.
Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals -
Wang, T.T., Schoene, N.W., Milner, J.A., Kim, Y.S. 2011. Broccoli-derived phytochemicals indole-3-carbinol and 3,3’-diindolylmethane exert concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals. Molecular Carcinogenesis. DOI: 10.1002/mc.20774.
Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties -
Xie, Z., Liu, W., Huang, H., Slavin, M., Zhao, Y., Whent, M., Blackford, J., Lutterodt, H., Zhou, H., Chen, P., Wang, T.T., Liangli, Y. 2010. Chemical composition of five commercial gynostemma pentaphyllum samples and their radical scavenging, antiproliferative, and anti-inflammatory properties. Journal of Agricultural and Food Chemistry. 58(21):11243-11249.
Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells -
Zhang, J., Wu, M., Schoene, N.W., Cheng, W., Wang, T.T., Alshatwi, A.A., Alsaif, M., Lei, K.Y. 2009. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. American Journal of Physiology - Cell Physiology. 297(3):C632-644.
Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells -
Wang, T.T., Schoene, N.W., Kim, Y.S., Mizuno, C.S., Rimando, A.M. 2010. Differential effects of resveratrol and its methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells. Molecular Nutrition and Food Research. 54(3):335-344.
Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells -
Trasino, S.E., Kim, Y.S., Wang, T.T. 2009. Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. Molecular Cancer Therapeutics. 8(7):1934-1945.
Selenoprotein W Modulates Control of Cell Cycle Entry Reprint Icon -
Hawkes, W.C., Wang, T.T., Alkan, Z., Richter, D., Dawson, K. 2009. Selenoprotein W Modulates Control of Cell Cycle Entry. Humana Press Inc, Biological Trace Element Research. 131:229-244.
Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP Reprint Icon -
Payton-Stewart, F., Schoene, N.W., Kim, Y.S., Burrow, M.E., Cleveland, T.E., Boue, S.M., Wang, T.T. 2009. Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP. Molecular Carcinogenesis. 48(9):862-871.
Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. -
Wang, T.T., Hudson, T.S., Wang, T.C., Remsberg, C.M., Davies, N.M., Takahashi, Y., Kim, Y.S., Seifried, H., Vinyard, B.T., Perkins, S.N., Hursting, S.D. 2008. Differential effects of resveratrol on androgen-responsive LNCaP human prostrate cancer cells in vitro and in vivo. Carcinogenesis. 29(10):2001-2010.
Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. -
Lavigne, J.A., Takahashi, Y., Chandramouli, G.V., Liu, H., Shih, J., Perkins, S.N., Hursting, S.D., Barrett, J., Wang, T.T. 2007. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Research and Treatment. [DOI 10.1007/s10549-007-9705-6].
Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms -
Hudson, T.S., Hartle, D.K., Hursting, S.D., Nunez, N.P., Wang, T.T., Young, H.A., Arany, P., Green, J.E. 2007. Inhibition of prostate cancer growth by muscadine grapeskin extract and resveratrol through distinct mechanisms. Cancer Research. 67(17):8396-8405.
Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. -
Trasino, S.E., Harrison, E.H., Wang, T.T. 2007. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in androgen responsive human prostate cancer cell LNCaP. Experimental Biology and Medicine (Maywood). 232(6):762-771.
MOLECULAR SIGNATURES OF SOY-DERIVED PHYTOCHEMICALS IN ANDROGEN-RESPONSIVE PROSTATE CANCER CELLS: A COMPARISON STUDY USING DNA MICROARRAY -
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Kim, Y.S., Wang, T.T. 2006. Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using dna microarray. Molecular Carcinogenesis. 12:943-956.
ENHANCED ESTROGENIC RESPONSES AND SENSITIVITY TO AZOSYMETHANE FOLLOWING DIETARY SOY ISOFLAVONE SUPPLEMENTATION IN OLDER FEMALE RATS -
Daly, K.T., Tracy, A.C., Malik, M., Wang, T.T., Francke-Carroll, S., Magnuson, B.A. 2007. Enhanced estrogenic responses and sensitivity to azosymethane following dietary soy isoflavone supplementation in older female rats. Food and Chemical Toxicology. 45(4):628-637.
17BETA-ESTRADIOL DIFFERENTIALLY REGULATES ANDROGEN-RESPONSIVE GENES THROUGH AN ESTROGEN RECEPTOR-BETA-DEPENDENT PATHWAY IN LNCAP HUMAN PROSTATE CANCER CELLS -
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2007. 17beta-estradiol differentially regulates androgen-responsive genes through an estrogen receptor-beta-dependent pathway in lncap human prostate cancer cells. Molecular Carcinogenesis. E-publication. 46(2):117-129.
DECIPHERING MOLECULAR SIGNATURES OF PHYTOCHEMICALS IN CELLS -
Wang, T.T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Gadisetti, C.R., Lavigne, J.A., Takahashi, Y. 2005. Deciphering molecular signatures of phytochemicals in cells. UJNR Food & Agricultural Panel Proceedings.
GENISTEIN AFFECTS ANDROGEN-RESPONSIVE GENES THROUGH BOTH ANDROGEN RECEPTOR- AND ESTROGEN RECEPTOR-MEDIATED PATHWAYS -
Takahashi, Y., Hursting, S.D., Perkins, S.N., Wang, T.T. 2006. Genistein affects androgen-responsive genes through both androgen receptor- and estrogen receptor-mediated pathways. Molecular Carcinogenesis. 45:18-25.
PHYTOCHEMICALS AS MODULATOR OF APOPTOSIS PATHWAYS -
Wang, T.T., Wang, T., Kim, Y.S., Hursting, S.D., Perkins, S.N., Lavigne, J.A., Leh, Y., Takahashi, Y. 2004. Phytochemicals as modulator of apoptosis pathways. United Stats/Japan Nutrition Research (UJNR) Food and Agricultural Panel Proceedings. p.149-152.
USING DNA MICROARRAY ANALYSES TO ELUCIDATE THE EFFECTS OF GENISTEIN IN ANDROGEN-DEPENDENT PROSTATE CANCER CELLS: IDENTIFICATION OF NOVEL TARGETS FOR CANCER PREVENTION -
Takahashi, Y., Lavigne, J.A., Hursting, S.D., Chandramouli, G.V., Perkins, S.N., Barrett, C., Wang, T.T. 2004. Using dna microarray analyses to elucidate the effects of genistein in androgen-dependent prostate cancer cells: identification of novel targets for cancer prevention. Molecular Carcinogenesis, Vol. 1 (2), pp. 108-119.
NUMERICAL DECONVOLUTION OF CDNA MICROARRAY SIGNAL -
Rosenfeld, S., Wang, T.T.Y., Young, K., and Milner, J. Numerical deconvolution of cDNA microarray signal, Ann. N.Y. Acad. Sci., 1020:110-123, 2004.
UTIITY OF MICROARRAY TECHNOLOGY IN STUDIES OF CANCER PREVENTIVE PHYTOCHEMICALS (ABSTRACT, US-JAPAN NATURAL RESOURCES PANEL MEETING, TSUKUBA, JAPAN, NOVEMBER 7-15, 2003) -
Wang, T.T., Lavigne, J.A., Hursting, D.S., Chandramouli, G.V.R., Takahashi, Y. 2003. Utillity of microarray technology in studies of cancer preventive phytochemicals. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members Meeting, Tsukuba, Japan. 304-307.
SOY ISOFLAVONE GENISTEIN MODULATES EXPRESSION OF AN ANDROGEN-RESPONSIVE GENE SPAK IN HUMAN PROSTATE CANCER (US-JAPAN NATURAL RESOURCES PANEL MEETING, TSUKUBA, JAPAN, NOVEMBER 7-15, 2003) -
Takahashi, Y., Hursting, D.S., Wang, T.T. 2003. Soy isoflavone genistein modulates expression of an androgen-respnsive gene SPAK in human prostate cancer cells. Proceedings of the 32nd Annual Meeting of the United States-Japan Natural Resources Food and Agriculture Panel Members, Tsukuba, Japan. 313-315.
GENISTEIN-INDUCED APOPTOSIS IN MCF-7 CELLS INVOLVES CHANGES IN BAK AND BEL-X WITHOUT EVIDENCE OF ANTI-OESTROGENIC EFFECTS -
BETA-NAPHTHOFLAVONE, AN INDUCER OF XENOBIOTIC METABOLIZING ENZYMES, I LUCIFERASE ACTIVITY -
Wang, T.T. 2002. Beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes,inhibits luciferase activity. Analytical Biochemistry. 304:122-126.
LOW DOSE GENISTEIN INDUCES CYCLIN-DEPENDENT KINASE INHIBITORS AND G1 CELL CYCLE ARREST IN HUMAN PROSTATE CANCER CELLS -
MODULATION OF CYCLOPHILIN GENE EXPRESSION BY N-4-(HYDROXYPHENYL) RETINAMIDEASSOCIATION WITH REACTIVE OXYGEN SPECIES GENERATION AND APOPTOSIS -
ARS News Articles
Last Modified: 5/2/2016
Footer Content Back to Top of Page