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United States Department of Agriculture

Agricultural Research Service

Darshan S Kelley
Research Chemist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Citrus limonin glucoside supplementation decreased biomarkers of liver disease in overweight human subjects -
Kelley, D.S., Adkins, Y.C., Zunino, S.J., Woodhouse, L., Bonnel, E., Breksa Iii, A.P., Manners, G.D., Mackey, B.E. 2014. Citrus limonin glucoside supplementation decreased biomarkers of liver disease in overweight human subjects. Journal of Functional Foods. 12:271-281. doi: 10.1016/jff.2014.11.026.
Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults -
Zunino, S.J., Storms, D.H., Freytag, T.L., Adkins, Y.C., Bonnel, E.L., Woodhouse, L.R., Breksa Iii, A.P., Manners, G.D., Mackey, B.E., Kelley, D.S. 2016. Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults. Nutrition Research. doi: 10.1016/j.nutres.2015.10.011.
Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice -
Schuster, G.U., Bratt, J., Jiang, X., Pedersen, T.L., Grapov, D., Adkins, Y.C., Kelley, D.S., Newman, J.W., Kenyon, N.J., Stephensen, C.B. 2014. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. American Journal of Respiratory Cell and Molecular Biology. doi: 10.1165/rcmb.2013-0136OC.
Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans -
Kelley, D.S., Adkins, Y.C., Reddy, A., Woodhouse, L.R., Mackey, B.E., Erickson, K.L. 2013. Sweet bing cherries lower circulating concentrations of markers for chronic inflammatory diseases in healthy humans. Journal of Nutrition. DOI: 10.3945/jn.112.171371.
The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle -
Fedor, D.M., Adkins, Y.C., Newman, J.W., Mackey, B.E., Kelley, D.S. 2013. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose and muscle. Metabolic Syndrome and Disorders. 11(1):63-70. DOI: 10.1089/met.2012.0116.
Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans -
Armstrong, P., Kelley, D.S., Newman, J.W., Staggers, F., Hartiala, J., Allayee, H., Stephensen, C.B. 2012. Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans. Journal of Nutrition. 142(8):1417-1428. DOI: 10.3945/jn.112.159814.
Docosahexaenoic acid prevents trans-10, cis-12 conjugated linoleic acid-induced non-alcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation -
Fedor, D.M., Adkins, Y.C., Mackey, B.E., Kelley, D.S. 2012. Docosahexaenoic acid prevents trans-10, cis-12 conjugated linoleic acid-induced non-alcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation. Metabolic Syndrome and Disorders. 10(3):175-180. DOI: 10.1089/met.2011.0113.
Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects -
Zunino, S.J., Parelman, M., Freytag, T.L., Stephensen, C.B., Kelley, D.S., Mackey, B.E., Woodhouse, L.R., Bonnel, E. 2011. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. British Journal of Nutrition. 1-10. DOI: 10.1017/S0007114511006027.
Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men -
Kelley, D.S., Adkins, Y.C., Woodhouse, L.R., Swislocki, A., Mackey, B.E., Siegel, D. 2012. Docosahexaenoic acid supplementation improved lipocentric but not glucocentric markers of insulin sensitivity in hypertriglyceridemic men. Metabolic Syndrome and Disorders. 10(1):32-38.
Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects -
Kelley, D.S., Adkins, Y.C. 2012. Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. Proceedings of the Nutrition Society. 10.1017/S0029665112000080.
Modulation of atherosclerosis by N-3 polyunsaturated fatty acids -
Kelley, D.S., Adkins, Y.C., Sharma, S., Fedor, D.M. 2011. Modulation of atherosclerosis by N-3 polyunsaturated fatty acids. In: Bidlack, W., Rodriguez, R., editors. The Impact of Dietary Regulation of Gene Function on Human Disease. New York, NY: CRC Press. p. 139-160.
Polyunsaturated fatty acids and insulin resistance -
Fedor, D.M., Kelley, D.S. 2012. Polyunsaturated fatty acids and insulin resistance. In: Watson, R.R., Preedy, V.R., editors. Bioactive Food as Dietary Interventions for Diabetes. San Diego, CA: Academic Press, Elsevier. pp 183-194.
Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men Reprint Icon -
Dawson, K., Zhao, L., Adkins, Y.C., Rodriguez, R.L., Kelley, D.S., Hwang, D.H. 2011. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. Journal of Nutritional Biochemistry. Available: http://www.sciencedirect.com/science/article/pii/S0955286311000933
ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation Reprint Icon -
Stephensen, C.B., Armstrong, P., Newman, J.W., Pedersen, T.L., Legault, J., Schuster, G., Kelley, D.S., Vikman, S., Hartiala, J., Hooman, A. 2011. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation. Journal of Lipid Research. 52(5):991-1003.
DHA Supplementation Decreases Serum C - Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men1-3 Reprint Icon -
Kelley, D.S., Siegel, D., Fedor, D.M., Adkins, Y.C., Mackey, B.E. 2009. Docosahexaenoic Acid Supplementation Decreases Serum C - Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men1-3. Journal of Nutrition. 138: 30-35, 2008.
Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and increases omega-3 index in hypertriglyceridemic men1-3. Reprint Icon -
Kelley, D.S., Siegel, D., Vemuri, M., Chung, G.H., Mackey, B.E. 2007. Docosahexaenoic acid supplementation decreases remnant-like particle-cholesterol and improves omega-3 index in hypertriglyceridemic men1-3.. Journal of Nutrition. 2007. Journal Nutrition 138:30-35, 2008.
Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Reverses Trans-10, Cis-12 Conjugated Linoleic Acid Induced Insulin Resistance in Mice1 -
Vemuri, M., Kelley, D.S., Mackey, B.E., Rasooly, R., Bartolini, G.L. Docosahexaenoic Acid (DHA) But Not Eicosapentaenoic Acid (EPA) Reverses Trans-10, Cis-12 Conjugated Linoleic Acid Induced Insulin Resistance in Mice. Metabolic Syndrome and Related Disorders, 2007 Vol.5, No.4:315-322.
Health Effects of Foods Rich in Polyphenols -
Vermuri, M., Kelley, D.S., Erickson, K. 2008. Health Effects of Foods Rich in Polyphenols. Book Chapter, "Wild-Type Food in Health Promotion and Disease Prevention, The Columbus Concept. De Meester, Fabien; Watson, Ronald R. (Eds.) Humana Press, Chapter 27;pp.393-412.
Docosahexaenoic acid supplementation improves fasting and postprandial plasma lipid profiles in hypertriglyceridemic men. Reprint Icon -
Kelley, D.S., Siegel, D., Vemuri, M., Mackey, B.E. 2007. Docosahexaenoic acid supplementation improves fasting and postprandial plasma lipid profiles in hypertriglyceridemic men. American Journal of Clinical Nutrition. 86:324-333, 2007.
The Effects of Dietary Fatty Acids on Lipid Metabolism -
Vemuri, M., Kelley, D.S. 2007. The Effects of Dietary Fatty Acids on Lipid Metabolism. Book Chapter in, "Fatty Acids in Foods and their Health Implications, third edition". CRC Press Taylor & Francis Group pp.591-630.
DIETARY T10, C-12-CONJUGATED LINOLEIC ACID REDUCES THE EXPRESSION OF FATTY ACID OXIDATION AND DRUG DETOXIFICATION ENZYMES IN MOUSE LIVER -
Rasooly, R., Kelley, D.S., Greg, J., Mackey, B.E. Dietary t10, c-12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver. Journal of Nutrition. 97:58-66, 2007.
FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC -
Kelley, D.S., Bartolini, G.L., Newman, J.W., Vemuri, M., Mackey, B.E. 2006. FATTY ACID PROFILES OF LIVER, ADIPOSE TISSUE, SPLEEN, AND HEART OF MICE FED DIETS CONTAINING T10, C-12-, AND C9, T11-CONJUGATED LINOLEIC ADIC. Prostaglandins Leukotrienes and Essential Fatty Acids. 74:331-338.
THE INNATE IMMUNE SYSTEM - FRIEND AND FOE -
Kelley, D.S., Stephensen, C.B. 2006. THE INNATE IMMUNE SYSTEM - FRIEND AND FOE. American Journal of Clinical Nutrition. 83:187-188, 2006.
CONSUMPTION OF BING SWEET CHERRIES LOWERS CIRCULATING CONCENTRATIONS OF INFLAMMATION MARKERS IN HEALTHY MEN AND WOMEN -
Kelley, D.S., Rasooly, R., Jacob, R.A., Kader, A.A., Mackey, B.E. 2006. CONSUMPTION OF BING SWEET CHERRIES LOWERS CIRCULATING CONCENTRATIONS OF INFLAMMATION MARKERS IN HEALTHY MEN AND WOMEN. Journal of Nutrition. 136:981-986, 2006.
DIETARY FAT AND IMMUNITY IN HUMANS -
Erickson, K.L., Kelley, D.S., Hubbard, N.E. Dietary fat and immunity in humans. Humana Press, Scientific and Medical Publishers, Handbook of Nutrition and Immunology. 2004 Chp.7:141152.
CONTRASTING EFFECTS OF 110, C-12-, AND C9, T11-CONJUGATED LINOLEIC ACID ISOMERS ON FATTY ACID PROFILES OF MOUSE LIVER LIPIDS -
Kelley, D.S., Bartolini, G.L., Warren, J.M., Simon, V.A., Mackey, B.E., Erickson, K.L. 2004. Contrasting effects of 110, c-12-, and c9, t11-conjugated linoleic acid isomers on fatty acid profiles of mouse liver lipids. Lipids. 39:135-141.
DIETARY FAT, IMMUNITY AND CANCER -
Erickson, K.L., Kelley, D.S., Hubbard, N.E. Dietary fat, immunity and cancer. Diet and Human Immune Function. Humana Press Inc., Totowa, NJ, chapter 18,pp345-360
LONG-TERM HIGH COPPER INTAKE: EFFECTS ON INDICES OF COPPER STATUS, ANTIOXIDANT STATUS, AND IMMUNE FUNCTION IN YOUNG MEN -
Turnlund, J.R., Jacob, R.A., Keen, C.L., Strain, J.J., Kelley, D.S., Domek, J.M., Keyes, W.R., Ensunsa, J.L., Lykkesfeldt, J., Coulter, J. 2004. Long-term high copper intake: effects on indices of copper status, antioxidant status, and immune function in young men. American Journal of Clinical Nutrition. 79:1037-1044.
Trans-10, CIS-12 conjugated linoleic acid increases liver and decreases adipose tissue lipids in mice: possible role of specific lipid metabolism genes -
Warren, J.M., Simon, V.A., Bartolini, G.L., Erickson, K.L., Mackey, B.E., Kelley, D.S. 2003. TRANS-10, CIS-12 CONJUGATED LINOLEIC ACID INCREASES LIVER AND DECREASES ADIPOSE TISSUE LIPIDS IN MICE: POSSIBLE ROLE OF SPECIFIC LIPID METABOLISM GENES. Lipids Journal. 38(5):497-504, 2003.
IMMUNE FUNCTIONS ARE MAINTAINED IN HEALTHY MEN WITH LOW ZINC INTAKE -
Pinna, K., Kelley, D.S., Taylor, P.C., King, J.C. 2002. IMMUNE FUNCTIONS ARE MAINTAINED IN HEALTHY MEN WITH LOW ZINC INTAKE. Journal of Nutrition. 132:2033-2036, 2002.
THE EFFECT OF CONJUGATED LINOLEIC ACID ON PLATELET FUNCTION, PLATELET FATTYACID COMPOSITION, AND BLOOD COAGULATION IN HUMANS -
EFFECT OF INDIVIDUAL FATTY ACIDS OF N-6 AND N-3 TYPE ON HUMAN IMMUNE STATUSAND ROLE OF EICOSANOIDS -
THE EFFECTS OF DIETARY SELENIUM ON THYROID HORMONES, ENERGY METABOLISM, SEMEN QUALITY, AND IMMUNE FUNCITON IN HEALTHY MEN -
DIETARY FAT AND HUMAN IMMUNE RESPONSE -
FATTY ACIDS AND IMMUNE FUNCTIONS -
DIETARY FATTY ACIDS AND IMMUNE FUNCTIONS -
EFFECTS OF DIETARY ARACHIDONIC ACID ON HUMAN IMMUNE RESPONSE: STIMULATION OF SECONDARY RESPONSE TO INFLUENZA VACCINE -
EFFECTS OF DIETARY ARACHIDONIC ACID (AA) ON HUMAN IMMUNE RESPONSE (IR) -
THE EFFECT OF DIETARY ARACHIDONIC ACID ON PLATELET FUNCTION, PLATELET FATTYACID COMPOSITION AND BLOOD COAGULATION IN HUMANS -
THE EFFECT OF DIETARY ARACHIDONIC ACID ON PLASMA LIPOPROTEIN DISTRIBUTIONS,APOPROTEINS, BLOOD LIPIDS LEVELS, AND TISSUE FATTY ACID COMPOSITION IN HUMANS. -
Last Modified: 8/26/2016
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