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United States Department of Agriculture

Agricultural Research Service

Research Project: DIET AND IMMUNE FUNCTION RELATED TO INFECTIOUS AND ALLERGIC DISEASE

Location: Diet, Genomics and Immunology Lab

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Adaptation of innate lymphoid cells to nutrient deprivation promotes type 2 barrier immunity - (Peer Reviewed Journal)
Spencer, S.P., Wilhelm, C., Yang, Q., Hall, J.A., Bouladoux, N., Boyd, A., Nutman, T.B., Urban Jr, J.F., Wang, J., Bhandoola, A., Ramalingam, T.R., Wynn, T.A., Belkaid, Y. 2014. Adaptation of innate lymphoid cells to nutrient deprivation promotes type 2 barrier immunity. Science. 343(6169):432-7.
Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection     Reprint Icon - (Peer Reviewed Journal)
Notari, L., Riera, D.C., Sun, R., Bohl, J.A., Mcclean, L.P., Madden, K., Vanrooijen, N., Vanuytsel, T., Urban Jr, J.F., Zhao, A., Shea-Donohue, T. 2014. Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection. PLoS One. 23:9(1)e84763.
SerpinB2 is critical to Th2 immunity against enteric nematode infection - (Peer Reviewed Journal)
Zhao, A., Yang, Z., Sun, R., Grinchuk, V., Netzel-Arnett, S., Anglin, I.E., Driesbaugh, K.H., Notari, L., Bohl, J.A., Madden, K.B., Urban Jr, J.F., Antalis, T.M., Shea-Donahue 2013. SerpinB2 is critical to Th2 immunity against enteric nematode infection. Journal of Immunology. 190(11):5779-87.
Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity - (Peer Reviewed Journal)
Yang, Z., Grinchuk, V., Smith, A.D., Qin, B., Bohl, J.A., Sun, R., Notari, L., Zhang, Z., Sesaki, H., Urban Jr, J.F., Shea-Donahue, T., Zhao, A. 2013. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infection and Immunity. 81(6):1905-1914.
Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice - (Peer Reviewed Journal)
Smith, A.D., Cheung, L., Shea-Donohue, T., Urban Jr, J.F. 2013. Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice. Infection and Immunity. 81(7):2546-2553.
Structural and Functional Annotation of the Porcine Immunome     Reprint Icon - (Peer Reviewed Journal)
Dawson, H.D., Loveland, J., Pascal, G., Gilbert, J., Uenishi, H., Mann, K., Sang, Y., Zhang, J., Carvalho-Silva, D., Hunt, T., Hardy, M., Hu, Z., Zhao, S., Anselmo, A., Sinkai, H., Chen, C.T., Badaoui, B., Berman, D.J., Amid, C., Kay, M., Lloyd, D., Snow, C., Morozumi, T., Cheng, R., Bystrom, M., Bourneuf, E., Kapetanovic, R., Schwartz, J.C., Kataria, R., Astley, M., Fritz, E., Steward, C., Thomas, M., Wilming, L., Giuffra, E., Archibald, A., Bed'Hom, B., Beraldi, D., Ait-Ali, T., Blecha, F., Botti, S., Freeman, T., Hume, D.A., Lunney, J.K., Murtaugh, M.P., Reecy, J.M., Harrow, J., Rogel-Gaillard, C., Tuggle, C.K. 2013. Structural and Functional Annotation of the Porcine Immunome. Biomed Central (BMC) Genomics. 14:332-370.
Synthesis, biological activity, and bioavailability of moschamine, a safflomide-type phenylpropenoic acid amide found in Centaurea cyanus - (Peer Reviewed Journal)
Park, J.B. 2012. Synthesis, biological activity, and bioavailability of moschamine, a safflomide-type phenylpropenoic acid amide found in Centaurea cyanus. Natural Product Research. 26(16):1465-72.
Heligmosomoides polygyrus bakeri infection activates colonic FoxP3+ T cells enhancing their capacity to prevent colitis - (Peer Reviewed Journal)
Hang, L., Blum, A.M., Setiawan, T., Urban Jr, J.F., Stoyanoff, K., Weinstock, J.V. 2013. Heligmosomoides polygyrus bakeri infection activates colonic FoxP3+ T cells enhancing their capacity to prevent colitis. Journal of Immunology. 191(4):1927-34.
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity - (Peer Reviewed Journal)
Yang, Z., Grinchuk, V., Urban Jr, J.F., Bohl, J., Sun, R., Notari, L., Yan, S., Ramalingam, T., Keegan, A.D., Wynn, T.A., Shea-Donohue, T., Zhao, A. 2013. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One. 8(3):e59441,1-11.
Il-33-Induced Alterations in Murine Intestinal Function and Cytokine Responses Are Myd88, Stat6, and Il-13-Dependent - (Peer Reviewed Journal)
Yang, Z., Sun, R., Grinchuk, V., Blanco, J.A., Notari, L., Bohl, J.A., Mclean, L.P., Ramalingam, J.R., Wynn, T.A., Urban Jr, J.F., Vogel, S.N., Shea-Donohue, T., Zhao, A. 2013. IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13-dependent. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304(4):G381-389.
Characterization of Fecal Microbiota of Children With Diarrhea in 2 Locations in Colombia - (Peer Reviewed Journal)
Solano Aguilar, G., Fernandez Duarte, K., Ets, H.K., Molokin, A., Vinyard, B.T., Urban Jr, J.F., Guitierrez, M. 2013. Characterization of Fecal Microbiota of Children With Diarrhea in 2 Locations in Colombia. Journal of Pediatric Gastroenterology and Nutrition. 56:503-511.
Analysis of pig genomes provide insight into porcine demography and evolution - (Peer Reviewed Journal)
Groenen, M.A., Archibald, A.L., Uenishi, H., Tuggle, C., Takeuchi, Y., Rothschild, M.F., Rogel-Gaillard, C., Park, C., Milan, D., Hendrik-Jan, M., Li, S., Larkin, D., Kim, H., Franz, L.A., Caccamo, M., Hyeonju, A., Aken, B.L., Anselmo, A., Anthon, C., Auvil, L., Bouabid, B., Beattie, C.W., Bendixen, C., Berman, D.J., Blecha, F., Blomberg, J., Bolund, L., Bosse, M., Botti, S., Zhan, B., Bystrom, M., Capitanu, B., Silva, D.C., Chardon, P., Chen, C.T., Cheng, R., Choi, S., Chow, W., Clark, R.C., Clee, C., Crooijmans, R.P., Dawson, H.D., Dehais, P., De Sapio, F., Dibbits, B., Drou, N., Du, Z., Eversole, K., Fadista, J., Fairley, S., Faraut, T., Faulkner, G.J., Fowler, K.E., Fredholm, M., Fritz, E., Gilbert, J.G., Giuffra, E., Gorodkin, J., Griffin, D., Harrow, J.L., Hayward, A., Howe, K., Zhi-Liang, H., Humphray, S.J., Hunt, T., Hornshoj, H., Jeon, J., Jern, P., Jones, M., Jurka, J., Kanamori, H., Kapetanovic, R., Jaebum, K., Kim, J., Kim, K., Kim, T., Larson, G., Lee, K., Lee, K., Leggett, R., Lewin, H.A., Li, Y., Liu, W., Loveland, J.E., Lu, Y., Lunney, J.K., Ma, J., Madsen, O., Mann, K., Mathews, L., Mclaren, S., Morozumi, T., Murtaug, M.P., Narayan, J., Nguyen, D., Ni, P., Oh, S., Onteru, S., Rohrer, G.A., et al. 2012. Analysis of pig genomes provide insight into porcine demography and evolution. Nature. 491(7424):393-8.
Heligmosomoides induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut Tcell responses - (Peer Reviewed Journal)
Blum, A.M., Hang, L., Setiawan, T., Urban Jr, J.F., Stoyanoff, K., Leung, J., Weinstock, J.V. 2012. Heligmosomoides induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut Tcell responses. Journal of Immunology. Sept 1:189(5):2512-2520.
Acute effects of all-trans-retinoic acid in ischemic injury - (Peer Reviewed Journal)
Panickar, K.S., Dawson, H.D. 2012. Acute effects of all-trans-retinoic acid in ischemic injury. Translational Neuroscience. 3:2 DOI: 10.2478/S3380-012-0015-Z.
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization - (Peer Reviewed Journal)
Santiago, H.C., Leevan, E., Bennuru, S., Ribeiro-Gomes, F., Mueller, E., Wilson, M., Wynn, T., Garboczi, D., Urban Jr, J.F., Nutman, T.B. 2012. Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization. Journal of Allergy Clinical Immunology. 130:248-256.
An essential role for TH2-type response in limiting acute tissue damage during experimental helminth infection. - (Peer Reviewed Journal)
Chen, F., Liu, Z., Rozo, C., Wu, W., Bowdridge, S., Wynn, T., Urban Jr, J.F., Gauge, W. 2012. An essential role for TH2-type response in limiting acute tissue damage during experimental helminth infection.. Nature Medicine. 18(2):260-6.
Comparative assessment of the pig, mouse, and human genomes: A structural and functional analysis of genes involved in immunity - (Book / Chapter)
Dawson, H.D. 2011. Comparative assessment of the pig, mouse, and human genomes: A structural and functional analysis of genes involved in immunity. In: McAnulty,P.A., Dayan, A., Hastings, K.H., Ganderup, N.-C., editors. The Minipig in Biomedical Research. Boca Raton, FL: CRC Press. p. 321-341.
Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice - (Peer Reviewed Journal)
Smith, A.D., Cheung, L., Botero, S. 2011. Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice. Biological Trace Element Research. Available: dx.doi.org/10.1007/S12011-011-9071-4.
Critical role of intestinal epithelial cell-derived IL-25 in enteric nematode infection-induced changes in intestinal function - (Peer Reviewed Journal)
Zhao, A., Urban Jr, J.F., Sun, R., Stiltz, J., Morimoto, M., Notari, L., Madden, K., Ramalingam, T., Wynn, T., Shea-Donohue, T. 2010. Critical role of intestinal epithelial cell-derived IL-25 in enteric nematode infection-induced changes in intestinal function. Journal of Immunology. 185:6921-6929.
Role of enteric nerves in immune-mediated changes in protease activated receptor 2 effects on gut function - (Peer Reviewed Journal)
Shea-Donohue, T., Notari, L., Stiltz, J., Sun, R., Madden, K.B., Urban Jr, J.F., Zhao, A. 2010. Role of enteric nerves in immune-mediated changes in protease activated receptor 2 effects on gut function. Neurogastroenterology & Motility. 10:1138-e291.
Helogmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity - (Peer Reviewed Journal)
Hang, L., Setiawan, T., Blum, A., Urban Jr, J.F., Stoyanoff, K., Reinecker, H.C., Weinstock, J. 2010. Helogmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. Journal of Immunology. 185(6):3184-9.
Enteric pathogens and gut function: role of cytokines and STATs - (Peer Reviewed Journal)
Shea-Donohue, T., Fasano, A., Smith, A.D., Zhao, A. 2010. Enteric pathogens and gut function: role of cytokines and STATs. Gut Microbes. 1(5):316-324.
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma - (Peer Reviewed Journal)
Yagi, R., Junttila, I., Wei, G., Urban Jr, J.F., Zhao, K., Paul, W., Zhu, J. 2010. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity. 32:507-517.
B cells have distinct roles in host protection against different nematode parasites - (Peer Reviewed Journal)
Liu, Q., Kreider, T., Bowdridge, S., Liu, Z., Song, Y., Gaydo, A.G., Urban, J.F. Jr., Gause, W.C. 2010. B cells have distinct roles in host protection against different nematode parasites. Journal of Immunology. 184(9):5213-5223.
Safety assessment of probiotics for human use - (Review Article)
Sanders, M.E., Akkermans, L.M.A., Haller, D., Hammerman, C., Heimbach, J.T., Hormannsperger, G., Huys, G., Levy, D.D., Lutgendorff, F., Mack, D., Phothirath, P., Solano-Aguilar, G., Vaughan, E. 2010. Safety assessment of probiotics for human use. Gut Microbes. 1(3):164-185.
Il25 Elicits a Multipotent Progenitor Cell Population That Promotes Th2 Cytokine Responses - (Peer Reviewed Journal)
Saenz, S.A., Siracusa, M.C., Perrigoue, J.G., Spencer, S.P., Urban Jr, J.F., Tocker, J.E., Budelsky, A.L., Kleinschek, M.A., Kambayashi, T., Artis, D. 2010. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature. 464(7923):1362-1366.
Characterization of porcine CD205 - (Peer Reviewed Journal)
Flores-Mendoza, L., Sotelo-Mundo, R.R., Dawson, H.D., Mwangi, W., Hernandez, J. 2010. Characterization of porcine CD205. Developmental and Comparative Immunology. 34(7):715-721.
Immune regulation of epithelial cell function: Implications for GI pathologies - (Peer Reviewed Journal)
Shea-Donohue, T., Notari, L., Urban Jr, J.F., Zhao, A. 2010. Immune regulation of epithelial cell function: Implications for GI pathologies. International Dairy Journal. 20(4):248-252.
Supplemental dietary inulin influences expression of iron and inflammation related genes in young pigs - (Peer Reviewed Journal)
Yasuda, K., Dawson, H.D., Wasmuth, E.V., Roneker, C.A., Chen, C., Urban, J.F., Welch, R.M., Miller, D.D., Lei, X.G. 2009. Supplemental dietary inulin influences expression of iron and inflammation related genes in young pigs. Journal of Nutrition. 139(11):2018-2023.
Characterization of effector mechanisms at the host: parasite interface during the immune response to tissue-dwelling intestinal nematode parasites - (Review Article)
Patel, N., Kreider, T., Urban Jr, J.F., Gause, W. 2009. Characterization of effector mechanisms at the host: parasite interface during the immune response to tissue-dwelling intestinal nematode parasites. International Journal for Parasitology. 39(1):13-21.
Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production - (Peer Reviewed Journal)
Elliott, D.E., Metwali, A., Leung, J., Setiawan, T., Blum, A.M., Ince, M.N., Bazzone, L.E., Stadecker, M.J., Urban Jr, J.F., Weinstock, J.V. 2008. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. Journal of Immunology. 181(4):2414-2419.
Last Modified: 7/24/2014
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