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United States Department of Agriculture

Agricultural Research Service

Research Project: Dietary Modulation of Obesity-Related Cancer by Selenium Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Consumption of a high-fat diet abrogates inhibitory effect of methylseleninic acid on spontaneous metastasis of Lewis lung carcinoma in mice - (Peer Reviewed Journal)
(05-Jul-14)
Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention - (Peer Reviewed Journal)
Zeng, H., Lazarova, D.L., Bordonaro, M. 2014. Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World Journal of Gastrointestinal Oncology. 6(2):41-51.
Plasma and breastmilk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementations: Breastfeeding, Antiretrovirals, and Nutrition Study - (Peer Reviewed Journal)
Flax, V.L., Bentley, M.E., Combs, G.F., Chasela, C.S., Kayira, D., Tegha, G., Kamwendo, D., Daza, E.J., Fokar, A., Kourtis, A.P., Jamieson, D.J., Van Der Horst, C.M., Adair, L.S. 2014. Plasma and breastmilk selenium in HIV-infected Malawian mothers are positively associated with infant selenium status but are not associated with maternal supplementations: Breastfeeding, Antiretrovirals, and Nutrition Study. American Journal of Clinical Nutrition. 99:950-956.
Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Graef, G.L., Claycombe, K.J., Johnson, L.K. 2013. Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice. Journal of Agricultural and Food Chemistry. 61:9373-9379.
Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Yee, J.A., Cao, J.J. 2013. Curcumin reduces trabecular and cortical bone in naive and Lewis lung carcinoma-bearing mice. Anticancer Research. 33:3153-3162.
Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice     Reprint Icon - (Peer Reviewed Journal)
Yuan, K., Xie, K., Fox, J., Zeng, H., Gao, H., Huang, C., Wu, M. 2013. Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology. 145:853–864.
Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-Adenosylmethionine-dependent methylation     Reprint Icon - (Peer Reviewed Journal)
Jackson, M.I., Lunoe, K., Gabel-Jensen, C., Gammelgaard, B., Combs, G.F. 2013. Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-Adenosylmethionine-dependent methylation. Journal of Nutritional Biochemistry. 24:2023-2030.
Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of MC-26 colon cancer xenografts in balb/c mice - (Peer Reviewed Journal)
Zeng, H., Cheng, W., Johnson, L.K. 2012. Methylselenol, a selenium metabolite, modulates p53 pathway and inhibits the growth of MC-26 colon cancer xenografts in balb/c mice. Journal of Nutritional Biochemistry. DOI:10.1016/j.nutbio.2012.04.008.
Activation of ERK signaling and induction of colon cancer cell death by piperlongumine     Reprint Icon - (Peer Reviewed Journal)
Randhawa, H., Kibble, K., Zeng, H., Mayer, M.P., Reindl, K.M. 2013. Activation of ERK signaling and induction of colon cancer cell death by piperlongumine. Toxicology In Vitro. 27:1626-1633.
Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Liu, J., Jackson, M.I., Zhao, F., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase in Lactobacillus species in the hind gut of C57BL/6 mice fed a high-fat diet. Journal of Nutrition. doi:10.3945/jn.112.172460.
Lentils (Lens culinaris L.) as a source of dietary selenium - (Book / Chapter)
Thavarajah, D., Thavarajah, P., Combs, G.F. 2013. Lentils (Lens culinaris L.) as a source of dietary selenium. Preedy, Victor R.; Srirajaskanthan, Rajaventhan; Patel, Vinood B., editors. Handbook of Food Fortification and Health. Vol. 2. Springer Science+Business Media New York., p. 255-264.
Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa     Reprint Icon - (Peer Reviewed Journal)
Moustafa, M., Carlson, B.A., Anver, M.R., Bobe, G., Zhong, N., Ward, J.M., Parella, C.M., Hoffmann, V.J., Rogers, K., Combs, G.F., Schweizer, U., Merlino, G.T., Gladyshev, V.N., Hatfield, D.L. 2013. Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa . PLoS One. 8(2): e57389. doi:10.1371/journal.pone.0057389.
Selenium in bone health: roles in antioxidant protection and cell proliferation     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Cao, J.J., Combs, G.F. 2013. Selenium in bone health: roles in antioxidant protection and cell proliferation. Nutrients. 5:97-110.
Methylselenol, a selenium metabolite, inhibits colon cancer cell growth in vitro and in vivo - (Abstract Only)
Zeng, H. 2013. Methylselenol, a selenium metabolite, inhibits colon cancer cell growth in vitro and in vivo. Federation of American Societies for Experimental Biology Conference. 27:860.13.
Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet - (Abstract Only)
Zeng, H., Liu, J., Jackson, M.I., Yan, L., Combs, G.F. 2013. Fatty liver accompanies an increase of Lactobacillus acidophilus in the hind gut of C57/BL mice fed a high-fat diet. Federation of American Societies for Experimental Biology Conference. 27:1067.4.
Plasma and breastmilk selenium in HIV-infected Malawian mothers is positively associated with infant selenium status at 2 or 6 and 24 weeks post-partum but is not associated with supplementation - (Abstract Only)
Flax, V.L., Bentley, M.E., Combs, G.F., Chasela, C.S., Kayira, D., Tegha, G., Daza, E.J., Jamieson, D.J., Van Der Horst, C.M., Adair, L.S. 2013. Plasma and breastmilk selenium in HIV-infected Malawian mothers is positively associated with infant selenium status at 2 or 6 and 24 weeks post-partum but is not associated with supplementation. Federation of American Societies for Experimental Biology Conference. 27:845.16.
Influences of fiber, methionine and form of selenium on selenium hindgut targeting and tissue accumulation - (Abstract Only)
Jackson, M.I., Padmanaban, K., Cao, J.J. 2013. Influences of fiber, methionine and form of selenium on selenium hindgut targeting and tissue accumulation. Federation of American Societies for Experimental Biology Conference. 27:860.16.
Effect of vitamin E on the immune system of ewes during late pregnancy and lactation     Reprint Icon - (Peer Reviewed Journal)
Anugu, S., Petersson-Wolfe, C.S., Combs, G.F., Petersson, K.H. 2012. Effect of vitamin E on the immune system of ewes during late pregnancy and lactation. Small Ruminant Research. 111:83-89.
S-Adenosylmethionine-dependent protein methylation Is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes     Reprint Icon - (Peer Reviewed Journal)
Jackson, M.I., Cao, J.J., Zeng, H., Uthus, E.O., Combs, G.F. 2012. S-Adenosylmethionine-dependent protein methylation Is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes. Journal of Biological Chemistry. 287(43):36455-36464.
Biomarkers in nutrition: new frontiers in research and application     Reprint Icon - (Proceedings)
Combs, G.F., Trumbo, P.R., Mckinley, M.C., Milner, J., Studenski, S., Kimura, T., Watkins, S.M., Raiten, D.J. 2013. Biomarkers in nutrition: new frontiers in research and application. Annals of the New York Academy of Sciences. 1278:1-10.
Geological impacts on nutrition - (Book / Chapter)
Combs, G.F. 2013. Geological impacts on nutrition. Selinus O., editor. Essentials of Medical Geology Revised Edition. Springer Science+Business Media Dordecht., p. 179-194.
Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L. 2012. Dietary supplementation with curcumin enhances metastatic growth of Lewis lung carcinoma in mice. International Journal of Cancer. 132:269-275.
Selenium and the regulation of cell cycle and apoptosis - (Book / Chapter)
(19-May-12)
Long-term voluntary running improves diet-induced adiposity in young adult mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Demars, L.C., Johnson, L.K. 2012. Long-term voluntary running improves diet-induced adiposity in young adult mice. Nutrition Research. 32:458-465.
Metabolic production of methylated selenium species requires adequate methylation status - (Abstract Only)
Jackson, M.I., Gabel-Jensen, C., Lunge, K., Gammelgaard, B., Combs, G.F. 2012. Metabolic production of methylated selenium species requires adequate methylation status. Federation of American Societies for Experimental Biology Conference. 26:241.6.
Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice - (Abstract Only)
Yan, L., Demars, L.C. 2012. Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. Federation of American Societies for Experimental Biology Conference. 26:376.2.
Non-motorized voluntary running does not affect experimental and spontaneous metastasis in mice - (Abstract Only)
Yan L, DeMars LC. Non-motorized voluntary running does not affect experimental and spontaneous metastasis in mice. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 March 31-April 4; Chicago, IL. Philadelphia (PA): AACR; 2012; 2012. Abst nr 595.
Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Demars, L.C. 2012. Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice. International Journal of Cancer. 131:1260-1266.
8-oxoguanine DNA glycosylase 1-deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice - (Peer Reviewed Journal)
Li, G., Yuan, K., Fox, J., Gaid, M., Seeger, D., Weaver, A., Breitwieser, W., Bansal, A.K., Zeng, H., Gao, H., Wu, M. 2012. 8-oxoguanine DNA glycosylase 1-deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radicals in Biology and Medicine. 15;52(2):392-401.
Effect of dietary selenium and cancer cell xenograft on peripheral T and B lymphocytes in adult nude mice     Reprint Icon - (Peer Reviewed Journal)
Cheng, W., Holmstrom, A., Li, X., Wu, R.T., Zeng, H., Xiao, Z. 2012. Effect of dietary selenium and cancer cell xenograft on peripheral T and B lymphocytes in adult nude mice. Biological Trace Element Research. 146:230-235.
Inverse association between gluthathione peroxidase activity and both selenium-binding protein 1 levels and gleason score in human prostate tissue     Reprint Icon - (Peer Reviewed Journal)
Jerome-Morais, A., Wright, M.E., Liu, R., Yang, W., Jackson, M.I., Combs, G.F., Diamond, A.M. 2012. Inverse association between gluthathione peroxidase activity and both selenium-binding protein 1 levels and gleason score in human prostate tissue. The Prostate Journal. 72(9): 1006-1012.
Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Demars, L.C. 2011. Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice. Anticancer Research. 31:3337-3344.
Selenium as a cancer preventive agent - (Book / Chapter)
Combs, G.F., Jackson, M.I. 2012. Selenium as a cancer preventive agent. In: Hatfield, D.L., Berry, M.J., Gladyshev, V.N. Selenium Its Molecular Biology and Role in Human Health. 3rd Edition. New York, NY: Springer. p. 313-323.
Genotype × Environment interactions for mineral concentration in grain of organically grown spring wheat     Reprint Icon - (Peer Reviewed Journal)
Murphy, K.M., Hoagland, L.A., Yan, L., Colley, M., Jones, S.S. 2011. Genotype × Environment interactions for mineral concentration in grain of organically grown spring wheat. Agronomy Journal. 103:1734–1741.
Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Briske Anderson, M.J., Wu, M., Moyer, M.P. 2012. Methylselenol, a selenium metabolite, plays common and different roles in cancerous colon HCT116 cell and noncancerous NCM460 colon cell proliferation. Nutrition and Cancer. 64(1):128-135.
Differential responses to selenomethioinine supplementation by sex and genotype in healthy adults     Reprint Icon - (Peer Reviewed Journal)
Combs, G.F., Jackson, M.I., Watts, J.J., Johnson, L.K., Zeng, H., Idso, J.P., Schomburg, L., Hoeg, A., Hoefig, C.S., Chiang, E.C., Waters, D.J., Tsuji, P.A., Davis, C.D., Milner, J.A. 2012. Differential responses to selenomethioinine supplementation by sex and genotype in healthy adults. British Journal of Nutrition. 107:1514-1525.
Determinants of selenium status in healthy adults     Reprint Icon - (Peer Reviewed Journal)
Combs, G.F., Watts, J.J., Jackson, M.I., Johnson, L.K., Zeng, H., Scheett, A.J., Uthus, E.O., Schomburg, L., Hoeg, A., Hoefig, C.S., Davis, C.D., Milner, J.A. 2011. Determinants of selenium status in healthy adults. Nutrition Journal. 10(75):1-10.
Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice - (Peer Reviewed Journal)
Holmstrom, A., Zeng, H., Lei, K., Cheng, W., Wu, R. 2012. Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice. Journal of Nutritional Biochemistry. 23(9):1086-91.
Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo - (Abstract Only)
(12-May-11)
Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Johnson, L.K. 2011. Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats. Journal of Agricultural and Food Chemistry. 59:6305-6311.
Dietary selenium intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa - (Abstract Only)
(11-Apr-11)
Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Yan, L., Cheng, W., Uthus, E.O. 2011. Dietary selenomethionine intake increases exon-specific DNA methylation of p53 gene in rat liver and colon mucosa. Journal of Nutrition. 141(8):1464-1468.
Obesity-related colon cancer: dietary factors and their mechanisms of anticancer action     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Lazarova, D.L. 2011. Obesity-related colon cancer: dietary factors and their mechanisms of anticancer action. Clinical and Experimental Pharmacology and Physiology. 39:161-167.
Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response - (Peer Reviewed Journal)
Zhang, S., Luo, Y., Zeng, H., Wang, Q., Tian, F., Song, J., Cheng, W. 2011. Encapsulation of selenium in chitosan nanoparticles improves selenium availability and protects cells from selenium-induced DNA damage response. Journal of Nutritional Biochemistry. 22(12):1137-42.
The potential of lentil (Lens culinaris L.) as a whole food for increased selenium, iron, and zinc intake: Preliminary results from a three year study     Reprint Icon - (Peer Reviewed Journal)
Thavarajah, D., Thavarajah, P., Wejesuriya, A., Rutzke, M., Glahn, R.P., Combs, G.F., Vandenberg, A. 2011. The potential of lentil (Lens culinaris L.) as a whole food for increased selenium, iron, and zinc intake: Preliminary results from a three year study. Euphytica. 180(1):123-128.
Effects of the physical form of the diet on food intake, growth, and body composition changes in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Combs, G.F., Demars, L.C., Johnson, L.K. 2011. Effects of the physical form of the diet on food intake, growth, and body composition changes in mice. Journal of the American Association for Laboratory Animal Science. 50(4):488-494.
A human model of selenium that integrates metabolism from selenite and selenomethionine     Reprint Icon - (Peer Reviewed Journal)
Wastney, M.E., Combs, G.F., Canfield, W.K., Taylor, P.R., Patterson, K.K., Hill, A.D., Moler, J.E., Patterson, B.H. 2011. A human model of selenium that integrates metabolism from selenite and selenomethionine. Journal of Nutrition. 141:708-717.
Chemical form of selenium affects its uptake, transport and glutathione peroxidase activity in the human intestinal Caco-2 cell model     Reprint Icon - (Peer Reviewed Journal)
Zeng, H., Jackson, M.I., Cheng, W., Combs, G.F. 2010. Chemical form of selenium affects its uptake, transport and glutathione peroxidase activity in the human intestinal Caco-2 cell model. Biological Trace Element Research. 143:1209-1218.
Obesity decreases serum selenium levels in DMBA-induced mammary tumor using Obese Zucker Rat Model - (Abstract Only)
Hakkak, R., Zeng, H., Lacher, C.P., Johnson, L.K., Korourian, S. 2011. Obesity decreases serum selenium levels in DMBA-induced mammary tumor using Obese Zucker Rat Model. Federation of American Societies for Experimental Biology Conference. 25:977.12.
Effect of dietary selenium on T cell immunity and cancer xenograft in nude mice - (Abstract Only)
Holmstrom, A., Li, X., Wu, R.T., Xiao, Z., Zeng, H., Lei, K.Y., Cheng, W. 2011. Effect of dietary selenium on T cell immunity and cancer xenograft in nude mice. Federation of American Societies for Experimental Biology Conference. 25:110.5.
Rapid determination of selenium in grain - (Abstract Only)
Combs, G.F., Lacher, C.P. 2011. Rapid determination of selenium in grain. Federation of American Societies for Experimental Biology Conference. 25:100.7.
Cellular methylation regulates hepatocyte expression of selenoprotein P and gluconeogenic enzymes - (Abstract Only)
Jackson, M.I., Combs, G.F. 2011. Cellular methylation regulates hepatocyte expression of selenoprotein P and gluconeogenic enzymes. Federation of American Societies for Experimental Biology Conference. 25:100.3.
Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo - (Abstract Only)
Zeng, H., Briske Anderson, M.J. 2011. Methylselenol, a selenium metabolite, plays a critical role in inhibiting colon cancer cell growth in vitro and in vivo. Federation of American Societies for Experimental Biology Conference. 25:110.4.
Chemical form of selenium affects its uptake and transport in the human intestinal cell model, Caco-2 - (Abstract Only)
Zeng, H., Jackson, M.I., Cheng, W., Combs, G.F. 2011. Chemical form of selenium affects its uptake and transport in the human intestinal cell model, Caco-2. Federation of American Societies for Experimental Biology Conference. 25:786.2.
Effects of diet-induced obesity on secondary tumor development and plasma cytokine expression in mice - (Abstract Only)
Yan, L., Demars, L.C. 2011. Effects of diet-induced obesity on secondary tumor development and plasma cytokine expression in mice. Federation of American Societies for Experimental Biology Conference. 25:977.11
Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epitehlial cells and in mice     Reprint Icon - (Peer Reviewed Journal)
Wu, M., Huang, H., Zhang, W., Kannan, S.H., Weaver, A., Mckibben, M., Herington, D., Zeng, H., Gao, H. 2011. Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epitehlial cells and in mice. Infection and Immunity. 79(1):75-87.
Selenium - (Book / Chapter)
COMBS, G.F. 2012. SELENIUM. IN:STIPANUK, M.H., CAUDILL, M.A., EDITORS. BIOCHEMICAL, PHYSIOLOGICAL, AND MOLECULAR ASPECTS OF HUMAN NUTRITION. 3RD EDITION. PHILADELPHIA, PA. SAUNDERS. 867-887.
Sulforaphane plays common and different roles in tumorigenic and nontumorigenic colon cell growth - (Abstract Only)
Zeng, H., Trujillo, O., Moyer, M.P., Botnen, J.H. 2010. Sulforaphane plays common and different roles in tumorigenic and nontumorigenic colon cell growth [abstract]. American Institute for Cancer Research . Poster No. 40.
Surveying selenium speciation from soil to cell—forms and transformations     Reprint Icon - (Review Article)
Gammelgaard, B., Jackson, M.I., Gabel-Jensen, C. 2011. Surveying selenium speciation from soil to cell—forms and transformations. Analytical and Bioanalytical Chemistry. 399:1743-1763.
Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice     Reprint Icon - (Peer Reviewed Journal)
Yan, L., Demars, L.C. 2010. Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Clinical and Experimental Metastasis. 27(8):581-590.
Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma and changes in plasma cytokine concentrations in mice - (Abstract Only)
Yan, L. 2010. Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma and changes in plasma cytokine concentrations in mice. American Association of Cancer Research Meeting. Abstract No.B41 p.107.
Last Modified: 7/30/2014
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