Location: Natural Products Utilization Research
2013 Annual Report
Pterostilbene was shown to inhibit progression of prostate cancer in animals. Pterostilbene inhibited the metastasis protein 1 (MTA1), and reduced tumor size more than resveratrol. This study found:.
The biting deterrent effect of a series of fatty acids against the yellow fever mosquito [Aedes (Ae.) aegypti] was investigated, in collaboration with an entomologist at the University of Mississippi. Bioassays on mid-chain length fatty acids showed at 24-h post treatment; lauric acid had a proportion not biting value higher than DEET at low concentrations and a similar value at higher concentrations. Cloth patch assays with human subjects at USDA, ARS, Center for Medical, Agricultural and Veterinary Entomology (CMAVE) showed that the mid-chain length fatty acids were not as effective as DEET against Ae. Aegypti.
Phenolic compounds from cashew nut shell liquid were evaluated for activity against Ae. aegypti larvae, in collaboration with CMAVE. Cardol and cardanol derivatives were active. Neither methylation nor hydrogenation of the compounds improved their activities. Large scale synthesis of a mosquito repellent, with duration of action three times longer than DEET, was performed. Toxicity studies were performed by a private company.
Collaboration with scientists from China and Brazil yielded:.
In collaboration with microbiologists from Brazil, bioactive compounds from fungi associated with macroalgae from Antarctica were surveyed. Penicillium spp. recovered from the endemic species Palmaria decipiens and Monostrama hariotii, respectively, yielded extracts with high and selective antifungal and/or trypanocidal activities. Extracts of the phytopathogenic fungi Fomitopsis and Epicoccum species were antifungal and phytotoxic. Acyl derivatives of glucinol were as active against the fish bacteria Flavobacterium columnare and Streptococcus iniae as a drug control.
Zhelijazkov, V.D., Cantrell, C.L., Donega, M.A., Astatkie, T. 2013. Bioprospecting for podophyllotoxin in the Big Horn Mountains, Wyoming. Industrial Crops and Products. 43:787-790.
Kun, L., Dias, S.J., Rimando, A.M., Dhar, S., Mizuno, C.S., Penman, A.D., Lewin, J.R., Levenson, A.S. 2013. Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor progression and metastasis in prostate cancer. PLoS One. 8(3):e557542.
Zheljazkov, V.D., Cantrell, C.L., Astatkie, T., Jeliazkova, E. 2012. Fall frosts effects on the essential oil of “Native” spearmint in Wyoming. Industrial Crops and Products. 47(11):1603-1606.
Zheljazkov, V.D., Cantrell, C.L., Astatkie, T., Jeliazkova, E. 2013. Distillation time effect on lavender essential oil yield and composition. Journal Oleo Science. 62(4):195-199.
Rosa, L., Tabanca, N., Techen, N., Pan, Z., Wedge, D.E., Moraes, R. 2012. Antifungal activity of extracts from endophytic fungi associated with Smallanthus maintained in vitro as autotrophic cultures and as pot plants in the greenhouse. Canadian Journal of Microbiology. 58:1202-1211.
Ali, A., Murphy, C., Demirci, B., Wedge, D.E., Sampson, B., Khan, I.A., Baser, H., Tabanca, N. 2013. Insecticidal and biting deterrent activity of rose-scented geranium (Pelargonium spp.) essential oils and individual compounds against Stephanitis pyrioides and Aedes aegypti. Pest Management Science. DOI 10.1002/ps.3518.
Rahim, A., Rimando, A.M., Silistrel, K., El-Alfy, A.T. 2013. Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation. Planta Medica. 19:723-730.
Shiwakoti, S., Shannon, D.A., Wood, C., Lawrence, K.S., Kemppainen, B., Joshee, N., Rimando, A.M. 2013. Harvesting number and timing effects on shoot yield and flavonoid content in organically grown American skullcap (Scutellaria lateriflora). Journal of Herbs, Spices and Medicinal Plants. 19:248-261.
Tabanca, N., Wedge, D.E., Ali, A., Khan, I.A., Kaplancikli, Z.A., Altintop, M.D. 2012. Antifungal, misquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives. Research and Reports in Medicinal Chemistry. 22:2602-2609.
Wedge, D.E., Curry, K.J., Kreiser, B., Curry, A., Abril, M., Smith, B.J. 2013. Fungicide resistance profiles for 13 Botrytis cinerea isolated from strawberry in southeastern Louisiana. International Journal of Fruit Science. 13(4):413-429.
Ali, A., Tabanca, N., Demirci, B., Baser, K., Ellis, J., Gray, S., Lackey, B., Murphy, C., Khan, I.A., Wedge, D.E. 2013. Composition, mosquito larvicidal, biting deterrent and antifungal activity of essential oils of different plant parts of Cupressus arizonica var. glabra (Carolina Sapphire). Natural Product Communications. 8(2):257-260.
Cantrell, C.L., Zheljazkov, V.D., Osbrink, W.L., Maddox, V., Craker, L., Khan, S. 2012. Podophyllotoxin and essential oil profile of Juniperus and related species. Industrial Crops and Products. 43:668-676.
Dias, S.J., Li, K., Rimando, A.M., Dhar, S., Mizuno, C.S., Penman, A.D., Levenson, A.S. 2013. Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. The Prostate Journal. 73:1135-1146.
Donega, M.A., Mello, S.C., Moraes, R.M., Cantrell, C.L. 2013. Nutrient uptake, biomass yield and quantitative analysis of aliphatic aldehydes in cilantro plants. Industrial Crops and Products. 44:127-131.
Godinho, V.M., Esteves, L.F., Santiago, T., Pellizari, F.M., Yokoya, N., Pupo, D., Alves, T., Junior, S., Romanha, A.J., Zani, C.L., Cantrell, C.L., Rosa, C.A., Rosa, L.H. 2013. Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica. The ISME Journal: Multidisciplinary Journal of Microbial Ecology. 7:1434-1451.
Kaymakcioglu, B., Celen, A.O., Nurhayat, T., Abbas, A., Khan, S.I., Khan, I.A., Wedge, D.E. 2013. Synthesis and biological activity of substituted urea and thiourea derivatives containing 1,2,4-triazole moiety. Molecules. 18(3):3562-3576.
Patel, P., Joshee, N., Rimando, A.M., Parajuli, P. 2013. Anti-cancer scopes and associated mechanisms of Scutellaria extract and flavonoid wogonin. Current Cancer Therapy Reviews. 9(1):34-42.
Tekippe, J.E., Hristov, A.N., Heyler, K.S., Zheljazkov, V.D., Ferreira, J.F.S., Cantrell, C.L., Varga, G.A. 2012. Effects of plants and essential oils on ruminal in vitro batch culture methane production and fermentation. Canadian Journal of Animal Science. 92:395-408.
Ali, A., Cantrell, C.L., Bernier, U.R., Duke, S.O., Schneider, J.C., Agramonte, N.M., Khan, I. 2012. Aedes aegypti (Diptera: culicidae) biting deterrence: structure-activity relationship of saturated and unsaturated fatty acids. Journal of Medical Entomology. 49:1370-1378.
Wang, X., Radwan, M.M., Tarawneh, A.H., Gao, J., Wedge, D.E., Rosa, L.G., Cutler, H., Cutler, S. 2013. Antifungal activity against plant pathogens of metabolites from the endophytic fungus Cladosporium cladosporioides. Journal of Agricultural and Food Chemistry. 61(19):4551-4555.
Nakano, H., Cantrell, C.L., Mamonov, L.K., Kustova, T.S., Fronczek, F.R., Ross, S.A. 2012. Chemical constituents from Echinops nanus and Echinops transiliensis. Biochemical Systematics and Ecology. 45:127-129.
Sakhanokho, H.F., Sampson, B.J., Tabanca, N., Wedge, D.E., Demirci, B., Husnu Can Baser, K., Bernier, U.R., Tsikolia, M., Agramonte, N.M., Becnel, J.J., Rajasekaran, K., Chen, J., Spiers, J.M. 2013. Chemical composition, antifungal and insecticidal activities of Hedychium essential oils. Molecules. 18:4308-4327.