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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Genetic and Biological Determinants of Avian Tumor Virus Pathogenicity, Transmission, and Evolution

Location: Avian Disease and Oncology Laboratory

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Mutations within ICP4 acquired during in vitro attenuation do not alter virulence of recombinant Marek’s disease viruses - (Peer Reviewed Journal)
Hildebrandt, E., Dunn, J.R., Niikura, M., Cheng, H.H. 2014. Mutations within ICP4 associated with in vitro attenuation do not alter in vivo virulence of recombinant Marek’s disease viruses. Virology. Virol Rep (2014). Available: http://dx.doi.org/10.1016/j.virep.2014.11.002.
A single nucleotide mutation within the UL5 helicase-primase subunit gene not only reduces virulence, but also provides partial vaccinal protection against Marek's disease - (Peer Reviewed Journal)
(13-Nov-14)
Further observations on serotype 2 Marek's Disease Virus-induced enhancement of spontaneous Avian Leukosis Virus-like bursal lymphomas in ALVA6 transgenic chickens - (Peer Reviewed Journal)
(08-Nov-14)
Succesive outbreaks of Marek's Disease in brown commercial layer chickens on the same farm - (Abstract Only)
Shivaprasad, H.L., Bland, M., Fadly, A.M., Dunn, J.R., Buscaglia, C. 2014. Succesive outbreaks of Marek's Disease in brown commercial layer chickens on the same farm. Meeting Abstract. Abstract No. 16663.
Partial attenuation of Marek's disease virus by manipulation of Di-codon bias - (Abstract Only)
Dunn, J.R., Silva, R.F. 2014. Partial attenuation of Marek's disease virus by manipulation of Di-codon bias [abstract]. In: Proceeding for 10th International Symposium on Marek's Disease and Avian Herpesviruses, July 20-23, 2014, East Lansing, Michigan. p.70.
Protective efficacy of a recombinant BAC clone of Marek's disease virus containing REV-LTR - (Abstract Only)
Mays, J.K., Dunn, J.R., Fadly, A.M. 2014. Protective efficacy of a recombinant BAC clone of Marek's disease virus containing REV-LTR [abstract]. In: Proceeding of 10th International Symposium on Marek's Disease and Avian Herpesviruses, July 20-23, 2014, East Lansing, Michigan. p. 84.
Marek’s disease virus induces transient atrophy of cecal tonsils - (Abstract Only)
Heidari, M., Fitzgerald, S.D., Zhang, H. 2014. Marek’s disease virus induces transient atrophy of cecal tonsils [abstract]. In: Proceeding for 10th International Symposium on Marek's Disease and Avian Herpesviruses, July 20-23, 2014, East Lansing, Michigan. p. 43.
Tumorous diseases of turkeys - an update - (Proceedings)
Fadly, A.M. 2014. Tumorous diseases of turkeys - an update. In: Proceedings of the 10th "Hafez" International Symposium on Turkey Diseases, June 5-7, 2014, Berlin Germany.
Characterizing the molecular basis of attenuation of Marek’s disease virus via in vitro serial passage - (Peer Reviewed Journal)
Hildebrandt, E.C., Dunn, J.R., Perumbakkam, S., Niikura, M., Cheng, H.H. 2014. Characterizing the molecular basis of attenuation of Marek’s disease virus via in vitro serial passage. Journal of Virology. 88(11):6232. Available: http://jvi.asm.org/content/88/11/6232#ref-list-1.
Correlation between Marek’s disease virus pathotype and replication - (Peer Reviewed Journal)
Dunn, J.R., Auten, K.A., Heidari, M., Buscaglia, C. 2014. Correlation between Marek’s disease virus pathotype and replication. Avian Diseases. 58:287-292.
The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek’s disease in chickens - (Peer Reviewed Journal)
Parvizi, P., Abdul-Careem, M.F., Mallick, A.I., Haq, K., Haghighi, H.R., Orouji, S., Heidari, M., Behboudi, S., Sharif, S. 2014. The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek’s disease in chickens. Vaccine. 32(17):1932-1938. Available: http://dx.doi.org/10.1016/j.vaccine.2014.01.082.
Marek’s disease virus-induced transient cecal tonsil atrophy - (Peer Reviewed Journal)
(24-Jan-14)
Detection and differentiation of CVI988 (Rispens vaccine) from other serotype 1 Marek’s disease viruses - (Peer Reviewed Journal)
Gimeno, I.M., Dunn, J.R., Cortes, A.L., El-Gohary, A., Silva, R.F. 2014. Detection and differentiation of CVI988 (Rispens vaccine) from other serotype 1 Marek’s disease viruses. Avian Diseases. 58:232-243.
Safety and efficacy of a backpassaged rMd5-delta-Meq vaccine virus in chickens - (Abstract Only)
Lee, L.F., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M. 2013. Safety and efficacy of a backpassaged rMd5-delta-Meq vaccine virus in chickens [abstract]. American Association of Avian Pathologists, July 19-23, 2013, Chicago, Illinois. p. 35.
Use of BAC clones as standardized reagents for Marek’s disease virus research - (Abstract Only)
Dunn, J.R., Cheng, H.H. 2014. Use of BAC clones as standardized reagents for Marek’s disease virus research. American Veterinary Medical Association Convention, July 25-29, 2014, Denver, Colorado. Abstract No. 16755.
Role of endogenous avian leukosis virus and serotype 2 Marek’s disease virus in enhancement of spontaneous lymphoid-leukosis-like tumors in chickens - (Abstract Only)
Fadly, A.M., Mays, J.K., Zhang, H., Hunt, H.D. 2014. Role of endogenous avian leukosis virus and serotype 2 Marek’s disease virus in enhancement of spontaneous lymphoid-leukosis-like tumors in chickens. American Veterinary Medical Association Annual Convention, July 25-29, 2014, Denver, Colorado. Abstract No. 16756.
Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen? - (Peer Reviewed Journal)
Allison, A.B., Keel, K.M., Philips, J.E., Cartoceti, A.N., Munk, B.A., Nemeth, N.M., Welsh, T.I., Thomas, J.M., Crum, J.M., Lichtenwalner, A.B., Fadly, A.M., Zavala, G., Holmes, E.C., Brown, J.D. 2014. Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen? Virology. 450-451:2-12. Available: http://dx.doi.org/10.1016/j.virol.2013.11.037.
Spontaenous Avian Leukosis Virus-like lymphomas in specific-pathogen-free chickens inoculated with serotype 2 Marek’s disease virus - (Abstract Only)
Fadly, A.M., Cao, W., Fulton, R.M., Mays, J.K. 2013. Spontaenous Avian Leukosis Virus-like lymphomas in specific-pathogen-free chickens inoculated with serotype 2 Marek’s disease virus [abstract]. American Association of Avian Pathologists, July 19-23, 2013, Chicago, Illinois. p. 31.
Role of NK cells in vaccine-induced immunity against Marek’s disease - (Abstract Only)
Heidari, M., Hunt, H.D. 2013. Role of NK cells in vaccine-induced immunity against Marek’s disease [abstract]. American Association of Avian Pathologists, July 19-23, 2013, Chicago, Illinois. p. 35.
Use of polymerase chain reaction in detection of Marek’s disease and reticuloendotheliosis viruses in formalin-fixed, paraffin-embedded tumorous tissues - (Peer Reviewed Journal)
Cao, W., Mays, J.K., Dunn, J.R., Fulton, R.M., Silva, R.F., Fadly, A.M. 2013. Use of polymerase chain reaction in detection of Marek’s disease and reticuloendotheliosis viruses in formalin-fixed, paraffin-embedded tumorous tissues. Avian Diseases. 57:785-789.
Deletion of Marek’s disease virus large subunit of ribonucleotide reductase (RR) impairs virus growth in vitro and in vivo - (Peer Reviewed Journal)
Sun, A., Lee, L.F., Khan, O., Heidari, M., Zhang, H., Lupiani, B., Reddy, S. 2013. Deletion of Marek’s disease virus large subunit of ribonucleotide reductase (RR) impairs virus growth in vitro and in vivo. Avian Diseases. 57(2):464-468.
Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek’s disease virus results in enhanced growth and protection - (Peer Reviewed Journal)
Lupiani, B., Lee, L.F., Kreager, K.S., Witter, R.L., Reddy, S.M. 2013. Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek’s disease virus results in enhanced growth and protection. Avian Diseases. 57(2):427-431.
Positive correlation between replication rate and pathotype of Marek’s disease virus strains in maternal antibody negative chickens - (Abstract Only)
Dunn, J.R., Auten, K.A., Heidari, M. 2013. Positive correlation between replication rate and pathotype of Marek’s disease virus strains in maternal antibody negative chickens [abstract]. American Association of Avian Pathologists, July 19-23, 2013, Chicago, Illinois. p. 34.
Cloning of a very virulent plus, 686 strain of Marek’s disease virus as a bacterial artificial chromosome - (Peer Reviewed Journal)
Reddy, S.M., Sun, A., Khan, O.K., Lee, L.F., Lupiani, B. 2013. Cloning of a very virulent plus, 686 strain of Marek’s disease virus as a bacterial artificial chromosome. Avian Diseases. 57(2):469-473.
Identification and in vitro characterization of a Marek’s disease virus encoded ribonucleotide reductase - (Peer Reviewed Journal)
Lee, L.F., Heidari, M., Sun, A., Zhang, H., Lupiani, B., Reddy, S.M. 2013. Identification and in vitro characterization of a Marek’s disease virus encoded ribonucleotide reductase. Avian Diseases. 57:178-187.
Current status of Marek’s disease in the United States & worldwide based on a questionnaire survey - (Peer Reviewed Journal)
Dunn, J.R., Gimeno, I.M. 2013. Current status of Marek’s disease in the United States & worldwide based on a questionnaire survey. Avian Diseases. 57(2):483-490.
Properties of a meq-deleted rMd5 Marek’s disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro - (Peer Reviewed Journal)
Lee, L.F., Kreager, K., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2013. Properties of a meq-deleted rMd5 Marek’s disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro. Avian Diseases. 57(2):491-497.
Leukosis/Sarcoma Group - (Book / Chapter)
Nair, V., Fadly, A.M. 2013. Leukosis/Sarcoma Group. In: Swayne, D.E, Glisson, J.R., McDougald, L.R., Nolan, L.K., Suarez, D.L., Nair, V., editors. Diseases of Poultry, 13th edition. Ames, IA: Wiley-Blackwell. p.553-592.
Reticuloendotheliosis - (Book / Chapter)
Nair, V., Zavala, G., Fadly, A.M. 2013. Reticuloendotheliosis. In: Swayne, D.E, Glisson, J.R., McDougald, L.R., Nolan, L.K., Suarez, D.L., Nair, V., editors. Diseases of Poultry, 13th edition. Ames, IA: Wiley-Blackwell. p.593-604.
Identification of lymphoproliferative disease virus in wild turkeys (Meleagris gallopavo) in the United States - (Proceedings)
Brown, J.D., Allison, A.B., Keel, K.M., Welch, T., Fadly, A.M. 2012. Identification of lymphoproliferative disease virus in wild turkeys (Meleagris gallopavo) in the United States. Proceedings for the 116th Annual Meeting of the United States Animal Health Association, October 18-October 24, 2012, Greensboro, North Carolina. 97-98.
Research update: Avian Disease and Oncology Laboratory avian tumor viruses - (Proceedings)
Fadly, A.M., Cheng, H.H., Dunn, J.R., Heidari, M., Hunt, H.D., Lee, L.F., Silva, R.F., Zhang, H. 2012. Research update: Avian Disease and Oncology Laboratory avian tumor viruses. United States Animal Health Association Proceedings. 513-516.
Role of alveolar macrophages in dissemination of Marek’s disease virus from lungs to lymphoid organs - (Abstract Only)
Heidari, M. 2012. Role of alveolar macrophages in dissemination of Marek’s disease virus from lungs to lymphoid organs. American Veterinary Medical Association Abstract. Paper No. 12500.
Large subunit of the ribonucleotide reductase gene is a virulent factor and plays a critical role in Marek's disease virus pathogenesis - (Abstract Only)
Lee, L.F., Sun, A., Heidari, M., Silva, R.F., Lupiani, B., Reddy, S.M. 2012. Large subunit of the ribonucleotide reductase gene is a virulent factor and plays a critical role in Marek's disease virus pathogenesis. American Veterinary Medical Association Abstract. Paper No. 12501.
Positive correlation between replication rate and pathotype of Marek’s disease virus strains in maternal antibody negative chickens - (Abstract Only)
Auten, K.M., Heidari, M., Dunn, J.R. 2012. Positive correlation between replication rate and pathotype of Marek’s disease virus strains in maternal antibody negative chickens. Meeting Abstract. Merial-NIH National Veterinary Scholar Sympsoium. Comparative Medicine: The Key to Translation, August 2-5, 2012, Loveland, Colorado.
Current status of Marek's disease in the united states and worldwide - (Abstract Only)
Dunn, J.R., Gimeno, I. 2012. Current status of Marek's disease in the united states and worldwide [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 53.
Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens. - (Abstract Only)
Lee, L.F., Kreager, K.S., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2012. Pathogenesis and protective efficacy of attenuated Meq null rMd5 virus in maternal antibody negative and commercial chickens [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 42.
Marek’s disease virus encoded ribonucleotide reductase large subunit is essential for in vivo replication and plays a critical role in viral pathogenesis. - (Abstract Only)
Sun, A., Lee, L.F., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M. 2012. Marek’s disease virus encoded ribonucleotide reductase large subunit is essential for in vivo replication and plays a critical role in viral pathogenesis [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 60.
Cloning of a very virulent plus, 686 strain of Marek’s disease virus as a bacterial artificial chromosome. - (Abstract Only)
Sun, A., Lupiani, B., Lee, L.F., Reddy, S.M. 2012. Cloning of a very virulent plus, 686 strain of Marek’s disease virus as a bacterial artificial chromosome [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 40.
Insertion of reticuloendotheliosis virus long terminal repeat into CVI988 strain of Marek’s disease virus results in enhanced growth and protection - (Abstract Only)
Lupiani, B., Lee, L.F., Sun, A., Witter, R.L., Reddy, S.M. 2012. Insertion of reticuloendotheliosis virus long terminal repeat into CVI988 strain of Marek’s disease virus results in enhanced growth and protection [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 31.
Some observations on the pathogenicity of a molecular clone of a very virulent strain of Marek’s disease virus containing an insert of long terminal repeat of reticuloendotheliosis virus - (Abstract Only)
Fadly, A.M., Mays, J.K., Silva, R.F., Kim, T. 2012. Some observations on the pathogenicity of a molecular clone of a very virulent strain of Marek’s disease virus containing an insert of long terminal repeat of reticuloendotheliosis virus [abstract]. 9th International Symposium on Marek's Disease and Avian Herpesviruses, June 24-28, 2012, Freie Universitat Berlin. p. 43.
Cell culture attenuation eliminates rMd5deltaMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease - (Peer Reviewed Journal)
Lee, L.F., Heidari, M., Zhang, H., Lupiani, B., Reddy, S.M., Fadly, A.M. 2012. Cell culture attenuation eliminates rMd5deltaMeq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease. Vaccine. 30(34):5151-5158.
Use of Polymerase chain reaction (PCR) in diagnosis of Marek’s disease and reticuloendotheliosis in formalin-fixed, paraffin-embedded tumorous tissues - (Abstract Only)
Fadly, A.M., Cao, W., Fulton, R.M., Mays, J.K., Dunn, J.R., Silva, R.F. 2012. Use of Polymerase chain reaction (PCR) in diagnosis of Marek’s disease and reticuloendotheliosis in formalin-fixed, paraffin-embedded tumorous tissues. Meeting Abstract. Paper No. 12498.
An overview of tumorous diseases of turkeys - (Proceedings)
Fadly, A.M. 2012. An overview of tumorous diseases of turkeys. In: Proceedings of the 9th International Symposium on Turkey Diseases, June 21-23, 2012, Berlin, Germany. p.178-182.
Molecular-genetic analysis of field isolates of Avian Leucosis Viruses in the Russian Federation - (Peer Reviewed Journal)
Plotnikov, V.A., Grebennikova, T.V., Yuzhakov, A.G., Dudnikova, E.K., Norkina, S.N., Zaberezhny, A.D., Aliper, T.I., Fadly, A.M. 2012. Molecular-genetic analysis of field isolates of Avian Leucosis Viruses in the Russian Federation. Problems of Virology. 57(5):39-43.
Ability of MEQ-deleted MDV vaccine candidates to adversely affect lymphoid organs and chicken weight gain - (Peer Reviewed Journal)
Dunn, J.R., Silva, R.F. 2012. Ability of MEQ-deleted MDV vaccine candidates to adversely affect lymphoid organs and chicken weight gain. Avian Diseases. 56:494-500.
Last Modified: 12/21/2014
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