Location: Animal Diseases Research
Project Number: 2090-32000-034-00
Start Date: Oct 06, 2011
End Date: Oct 05, 2016
The discovery of chemical (acaricide) resistant ticks capable of transmitting protozoan parasites that cause bovine babesiosis and the reemergence of equine babesiosis within the United States are the catalysts for this research plan. National concerns are eradication of the currently emerging equine babesiosis, the possibility of reemergence of bovine babesiosis and the need for novel methods to control the causal parasites and their tick vectors. The current strategy in the U.S. for bovine babesiosis is control of ticks through acaricides. However, the development of ticks resistant to acaricides is resulting in geographic expansion of these vectors in the U.S. Since cattle entry is not monitored by serology, infected cattle are entering the U.S. The risk of bovine babesiosis is significantly increased by the presence and expanding range of ticks capable of transmission and the lack of serologic monitoring of cattle. To protect the U.S. cattle population from babesiosis, this research plan proposes to develop novel immunological interventions and to use these tools to test the hypothesis that tick transmission of Babesia bovis can be blocked. The primary goal is to disrupt the B. bovis-tick interface at the level of the tick midgut and hemolymph. In contrast to bovine babesiosis, the control strategy for equine babesiosis is based on serological restriction of infected horses from entering the country. Due to previous use of the complement fixation test (CFT), which lacked sensitivity, infected horses have been admitted into the U.S. which likely led, at least in part, to the recent reemergence of this foreign equine disease in the U.S. The goal of this research plan related to equine babesiosis is to assist the Animal Plant Health Inspection Service (APHIS), State Veterinarians and owners in eliminating Babesia infections, transmission risk, and potential endemicity by developing pharmacological interventions.