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United States Department of Agriculture

Agricultural Research Service

Research Project: Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus (Fmdv)

Location: Foreign Animal Disease Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Salazar, A.M., Grubman, M.J., De Los Santos, T.B. 2014. Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine. Virology. 468-470C:283-292.
Virus-host interactions in persistently FMDV-infected cells derived from bovine pharynx - (Peer Reviewed Journal)
O'Donnell, V., Pacheco Tobin, J., Larocco, M.A., Gladue, D.P., Pauszek, S.J., Smoliga, G.R., Krug, P.W., Baxt, B., Borca, M.V., Rodriguez, L.L. 2014. Virus-host interactions in persistently FMDV-infected cells derived from bovine pharynx. Virology. 468-470C:185-196.
Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication. PLoS One. DOI:10.1371/journal.pone.0106859.
Fusion protein IRF7/3(5D) efficiently controls Foot-and-Mouth Disease Virus particles - (Peer Reviewed Journal)
Ramirez-Carvajal, L., Long, C.R., Zhu, J.J., Diaz San Segundo, F.C., Rodriguez, L.L., De Los Santos, T.B. 2014. Fusion protein IRF7/3(5D) efficiently controls Foot-and-Mouth Disease Virus particles. Journal of Virology. DOI:10.1128/JVI.00372-14.
Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Borca, M.V., Rodriguez, L.L., Arzt, J. 2014. Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A. Acta Veterinaria Scandinavica. 56(1):42.
Type III interferon protects swine against foot-and-mouth disease - (Peer Reviewed Journal)
Perez-Martin, E., Diaz San Segundo, F.C., Weiss, M., Sturza, D., Dias, C.C., Ramirez, E., Grubman, M.J., De Los Santos, T.B. 2014. Type III interferon protects swine against foot-and-mouth disease. Journal of Interferon and Cytokine Research. DOI:10.1089/jir.2013.0112.
Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2014. Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12235.
Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods - (Peer Reviewed Journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods. Research in Veterinary Science. 96:396-405.
Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon - (Peer Reviewed Journal)
Ludi, A., Ahmed, Z., Pomeroy, L.W., Pauszek, S.J., Smoliga, G.R., Moritz, M., Dickmu, S., Abdoulkadiri, S., Arzt, J., Garabed, R., Rodriguez, L.L. 2014. Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon. Transboundary and Emerging Diseases. DOI: 10.1111/TBED.12227.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection - (Peer Reviewed Journal)
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: role of jumonji C-domain containing protein 6 in RHA demethylation - (Peer Reviewed Journal)
Lawrence, P., Conderino, J., Rieder, A.E. 2014. Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: role of jumonji C-domain containing protein 6 in RHA demethylation. Virology. 452-453:1-11.
Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Arzt, J., Pauszek, S.J., Fernandez-Sainz, I., Fletcher, P., Brocchi, E., Lu, Z., Rodriguez, L.L., Borca, M.V. 2014. Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle. Journal of Virology. 88(5):2737-2747.
Enhanced IRES activity by the 3’UTR element determines the virulence of FMDV isolates - (Peer Reviewed Journal)
Garcia-Nunez, S., Gismondi, M.I., Konig, G., Berinstein, A., Taboga, O., Rieder, A.E., Martinez-Salas, E., Carrillo, E. 2014. Enhanced IRES activity by the 3’UTR element determines the virulence of FMDV isolates. Virology. 448:303-313.
Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase - (Peer Reviewed Journal)
Uddowla, S., Pacheco Tobin, J., Larson, C., Bishop, E.A., Rodriguez, L.L., Rai, D., Arzt, J., Rieder, A.E. 2013. Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase. Virology. 447(1-2):172-180.
A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle - (Peer Reviewed Journal)
Pacheco Tobin, J., Gladue, D.P., Holinka-Patterson, L.G., Arzt, J., Bishop, E.A., Smoliga, G.R., Pauszek, S.J., Bracht, A.J., O'Donnell, V., Fernandez-Sainz, I., Fletcher, P., Piccone, M.E., Rodriguez, L.L., Borca, M.V. 2013. A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology. 446(1-2):260-267.
Heterogeneity in the antibody response to foot-and-mouth disease primo-vaccinated calves - (Peer Reviewed Journal)
Di Giacomo, S., Brito, B.P., Perez, A.M., Bucafusco, D., Pega, J., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2013. Heterogeneity in the antibody response to foot-and-mouth disease primo-vaccinated calves. Transboundary and Emerging Diseases. DOI:10.1111/tbed.12130.
Understanding the mechanism of interferon-induced protection against foot-and-mouth disease - (Book / Chapter)
Diaz San Segundo, F.C., Montiel, N., De Los Santos, T.B., Grubman, M.J. 2014. Understanding the mechanism of interferon-induced protection against foot-and-mouth disease. In: IConcept Press, Ltd. Virology II Advanced Issues. 1st edition. United States of America: IConcept Press Ltd. p. 51-72.
Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity     Reprint Icon - (Review Article)
Toka, F.N., Golde, W.T. 2013. Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity. Immunology Letters. 152(2):135-143 DOI:10.1016/j.imlet.2013.05.007.
Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression     Reprint Icon - (Peer Reviewed Journal)
Zhu, J.J., Arzt, J., Puckette, M.C., Smoliga, G.R., Pacheco Tobin, J., Rodriguez, L.L. 2013. Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression. PLoS One. 8(5):e64119. DOI:10.1371/journal.pone.0064119.
Foot-and-mouth disease virus modulates cellular vimentin for virus survival     Reprint Icon - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Holinka-Patterson, L.G., Pacheco Tobin, J., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Piccone, M.E., Fletcher, P., Ambroggio, X., Rodriguez, L.L., Borca, M.V. 2013. Foot-and-mouth disease virus modulates cellular vimentin for virus survival. Journal of Virology. 87(12):6794-6803.
Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells.     Reprint Icon - (Peer Reviewed Journal)
Rai, D.K., Schafer, E.A., Singh, K., Mcintosh, M., Sarafianos, S., Rieder, A.E. 2013. Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells. Antiviral Research. 98(3):380-385 DOI:10.1016/j.antiviral.2013.03.022.
Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability     Reprint Icon - (Peer Reviewed Journal)
Maree, F.F., Blignaut, B., De Beer, T.A., Rieder, A.E. 2013. Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability. PLoS One. 8(5):e61612 DOI:10.1371/journal.pone.0061612.
Structure-based discovery of foot-and-mouth disease inhibitors that target the 3Dpol RNA-dependent RNA polymerase - (Peer Reviewed Journal)
(27-Feb-13)
An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine     Reprint Icon - (Peer Reviewed Journal)
Alejo, D.M., Moraes, M.P., Liao, X., Dias, C.C., Tulman, E.R., Diaz San Segundo, F.C., Rood, D., Grubman, M.J., Silbart, L.K. 2013. An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine. Vaccine. 313(18):2302-2309.
Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus     Reprint Icon - (Peer Reviewed Journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Owens, G., Custer, M., Kamrud, K., De Los Santos, T.B., Grubman, M.J. 2013. Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus. Journal of Virology. 87(10):5447-5460. DOI: 10.1128/JVI.03462-12.
Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle     Reprint Icon - (Peer Reviewed Journal)
Pega, J., Bucafusco, D., Di Giacomo, S., Malacari, D., Capozzo, A., Arzt, J., Perez-Beascoechea, C., Maradei, E., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2012. Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle. Journal of Virology. 87(5):2489-2495.
Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis     Reprint Icon - (Peer Reviewed Journal)
Lawrence, P., Uddowla, S., Pacheco Tobin, J., Kotecha, A., Fry, E., Rieder, A.E. 2012. Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis. Virology. 136(1):150-161.
Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism     Reprint Icon - (Peer Reviewed Journal)
Loughran, G., Libbey, J.E., Uddowla, S., Scallan, M.F., Ryan, M.D., Fujinami, R.S., Rieder, A.E., Atkins, J.F. 2013. Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism. Journal of General Virology. 94(2):348-353.
Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle     Reprint Icon - (Peer Reviewed Journal)
Montiel, N.A., Smoliga, G.R., Arzt, J. 2012. Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle. Veterinary Immunology and Immunopathology. 151(1-2):37-48. DOI: 110.1016/j.vetimm.2012.10.003.
Novel approaches to foot-and-mouth disease vaccine development - (Proceedings)
Ludi, A., Rodriguez, L.L. 2012. Novel approaches to foot-and-mouth disease vaccine development[abstract]. Vaccines and Diagnostics for Transboundary Animal Diseases. 135:107-116.
Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication     Reprint Icon - (Peer Reviewed Journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Baxt, B., Piconne, M.E., Rodriguez, L.L., Borca, M.V. 2012. Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication. Journal of Virology. 86(22):12080-12090. doi:10.1128/JVI.01610-12.
Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp)     Reprint Icon - (Peer Reviewed Journal)
Rai, D., Rieder, A.E. 2012. Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp). International Journal of Molecular Sciences. 2012(3):8998-9013.
Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401     Reprint Icon - (Peer Reviewed Journal)
Pedersen, L.E., Harndahl, M., Nielsen, M., Patch, J.R., Jungersen, G., Buus, S., Golde, W.T. 2012. Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401. Animal Genetics. 44(3):251-258. DOI: 10.1111/j.1365-2052.2012.02400.x
Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease - (Peer Reviewed Journal)
Grubman, M.J., Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Perez-Martin, E., De Los Santos, T.B. 2012. Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease. Future Virology. 7(8):767-778.
Novel antiviral therapeutics to control foot-and-mouth disease     Reprint Icon - (Peer Reviewed Journal)
Dias, C.C., Moraes, M.P., Weiss, M., Diaz San Segundo, F.C., Perez-Martin, E., Salazar, A.M., De Los Santos, T.B., Grubman, M.J. 2012. Novel antiviral therapeutics to control foot-and-mouth disease. Journal of Interferon and Cytokine Research. 32(10):462-473.
Foot-and-mouth disease virus serotype O phylodynamics: genetic variability associated with epidemiological factors in Pakistan - (Peer Reviewed Journal)
Brito, B.P., Perez, A.M., Jamal, S.M., Belsham, G.J., Pauszek, S.J., Ahmed, Z., Rodriguez, L.L. 2012. Foot-and-mouth disease virus serotype O phylodynamics: genetic variability associated with epidemiological factors in Pakistan. Transboundary and Emerging Diseases. 60(6):516-524.
Foot-and-mouth disease: global status and Indian perspective     Reprint Icon - (Peer Reviewed Journal)
Biswal, J.K., Sanyal, A., Rodriguez, L.L., Subramaniam, S., Arzt, J., Sharma, G.K., Hammond, J.M., Parida, S., Mohapatra, J.K., Mathapati, B.S., Dash, B.B., Ranjan, R., Rout, M., Venketaramanan, R., Misri, J., Krishna, L., Prasad, G., Pathak, K.M., Pattnaik, B. 2012. Foot-and-mouth disease: global status and Indian perspective. Indian Journal of Animal Sciences. 82(2):109-131.
Designing bovine T-cell vaccines via reverse immunology - (Review Article)
Nene, V., Svitek, N., Golde, W.T., Barlow, J., Buus, S., Nielsen, M. 2012. Designing bovine T-cell vaccines via reverse immunology. Ticks and Tick Borne Diseases. 3(2012):188-192.
Last Modified: 10/25/2014
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