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United States Department of Agriculture

Agricultural Research Service

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Research Project: Foot-and-Mouth Disease Surveillance, Diagnostics and Antigenic Matching Research in Uganda

Location: Foreign Animal Disease Research

Project Number: 8064-32000-057-32
Project Type: General Cooperative Agreement

Start Date: Oct 01, 2013
End Date: Mar 05, 2015

Objective:
Foot-and-Mouth Disease (FMD) is a high priority re-emerging zoonotic transboundary disease with high economic implications which threatens animal health and livestock production in sub-Saharan African nations. This research project seeks to improve Foot-and-Mouth Disease Virus (FMDV) surveillance and antigenic matching customized to the Uganda’s needs. Specific objectives of this collaboration include: 1. Conduct field sampling to identify the serotype, subtype and genetic makeup of FMDV circulating in Uganda that support current FMD surveillance program in this endemic country. 2. Conduct sequence determination and serological studies of FMDV circulating in Uganda in support of antigenic matching studies. 3. Conduct phylogenetic evaluation of FMDV strains. 4. Train Ugandan scientists in serological and molecular DNA techniques for the identification and characterization of FMDV types in endemic Uganda.

Approach:
1. In coordination with the Ministry of Agriculture, Animal Industry and Fisheries of Uganda, field samples of Foot-and-Mouth Disease (FMD) serotypes South African Territories (SAT), A and O will be obtained. Samples will be sequenced and the information obtained will be recorded for phylogenetic purposes. FMDV of SAT types will be sent to collaborators at South Africa's Agricultural Research Council-Onderstepoort Veterinary Institute (ARC-OVI) and types A and O to the ARS, PIADC for characterization and matching studies. This information, along with field surveillance data, will be provided to ARS, PIADC, Ugandan Veterinary Research Institute (UVRI) and other collaborators with epidemiological expertise for phylogenetic analysis. 2. ARC-OVI will provide training to Ugandan collaborators on serological cross-reactivity and molecular studies. The biological properties of selected field and laboratory altered FMDV variants will be determined. 3. In conjunction with collaborators from UVRI, OVI and ARS, PIADC, a FMD monitoring system, inclusive of epidemiological and surveillance data, will be established.

Last Modified: 10/21/2014
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