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United States Department of Agriculture

Agricultural Research Service

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Research Project: Foot-and-Mouth Disease Vaccine Matching and Virus Characterization Studies in Uganda

Location: Foreign Animal Disease Research

Project Number: 8064-32000-057-34
Project Type: General Cooperative Agreement

Start Date: Oct 01, 2013
End Date: Mar 05, 2015

Objective:
Foot-and-Mouth Disease (FMD) is a high priority re-emerging zoonotic transboundary disease with high economic implications which threatens animal health and livestock production in sub-Saharan African nations. This research project seeks to improve Foot-and-Mouth Disease Virus (FMDV) surveillance and vaccine developments customized to Uganda’s needs. Specific objectives of this collaboration include: 1. Characterization and sequence analysis of South African Territory (SAT) types FMD field samples provided by collaborators in Uganda. 2. Provide training to collaborators in Uganda to develop skills in viral characterization. 3. Provide technical assistance to collaborators in Uganda to develop FMD monitoring program.

Approach:
1. Field samples of FMD serotype SAT obtained by collaborators in Uganda will be sent to the Agricultural Research Council - Onderstepoort Veterinary Institute (ARC-OVI) for characterization and matching studies performed using ARC-OVI prototype strains and master serum. Samples will be sequenced and the information obtained will be processed for phylogenetic analysis. This information, along with field surveillance data, will be provided to ARS, PIADC and Uganda Virus Research Institute (UVRI) and to collaborators with epidemiological expertise to conduct phylogenetic studies. 2. ARC-OVI will provide training to Ugandan collaborators on serological cross-reactivity and molecular studies concerning SAT FMDVs. This information will aid in the development of recombinant FMD constructs for antigenic matching. 3. ARC-OVI will provide protocols and training to Uganda scientist using their experience handling FMDV in an endemic setting and in support to Uganda’s FMDV monitoring program.

Last Modified: 10/23/2014
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