Development of Improved Mucosal Foot-and-Mouth Disease Virus Vaccines
Foreign Animal Disease Research
Project Number: 1940-32000-057-44
Nonfunded Cooperative Agreement
Start Date: Jun 01, 2012
End Date: May 31, 2014
This collaborative research project seeks to develop novel approaches to induce mucosal immune responses to Foot-and-Mouth Disease Virus (FMDV) vaccines. Specifically, we will evaluate the efficacy of mucosal adjuvants, delivered via the replication-defective human adenovirus 5 (hAd5) vector system along with the hAd5-FMD vaccine, for augmenting immunity and protection following mucosal or parenteral administration, to mice and swine.
The evaluation of mucosal adjuvants efficacy delivered through the Ad5 platform, to induce mucosal immune responses to FMDV will be conducted alone or in combination with FMDV vaccine for induction of protection in swine. Challenge studies will be performed utilizing homotypic virus. Approaches to increase the efficacy of mucosally delivered Ad5-vectored mucosal adjuvants will be evaluated.