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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Discovery and Development of Natural Products for Pharmaceutical and Agrochemical Applications

Location: Natural Products Utilization Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Chemical composition, larvicidal, and biting deterrent activity of essential oils of two subspecies of Tanacetum argenteum (Asterales: Asteraceae) and individual constituents against Aedes aegypti (Diptera: Culicidae) - (Peer Reviewed Journal)
Ali, A., Tabanca, N., Kurkcuglu, M.K., Duran, A., Blythe, E., Khan, I.A., Can Baser, K. 2014. Chemical composition, larvicidal, and biting deterrent activity of essential oils of two subspecies of Tanacetum argenteum (Asterales: Asteraceae) and individual constituents against Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology. 51(4):1-7.
Antileukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora - (Peer Reviewed Journal)
Metwaly, A.M., Fronczek, F.R., Ma, G., Kadry, H.A., El-Hela, A.A., Mohammad, A.I., Cutler, S.J., Ross, S. 2014. Antileukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora. Tetrahedron Letters. 55:3478-3481.
Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline - (Peer Reviewed Journal)
Manda, V.K., Avula, B., Ali, Z., Khan, I.A., Walker, L., Khan, S.I. 2014. Evaluation of in vitro absorption, distribution, metabolism, and excretion (ADME) properties of mitragynine, 7-hydroxymitragynine, and mitraphylline. Planta Medica. 80:568-576.
Comparison of three chromatographic techniques for the detection of mitragynine and other indole and oxindole alkaloids in mitragyna speciosa (Kratom) plants - (Peer Reviewed Journal)
Wang, M., Carrell, E., Ali, Z., Avonto, C., Parcher, J., Khan, I. 2014. Comparison of three chromatographic techniques for the detection of mitragynine and other indole and oxindole alkaloids in mitragyna speciosa (Kratom) plants. Journal of Separation Science. PP 1-8.
Isolation and characterization of secondary metabolites from Asphodelus microcarpus - (Peer Reviewed Journal)
Ghoneim, M.M., Elokely, K.M., El-Hela, A.A., Mohammad, A.I., Jacob, M., Cutler, S.J., Doerksen, R.J., Ross, S. 2014. Isolation and characterization of secondary metabolites from Asphodelus microcarpus. Medicnal Chemistry Research. 23:3510-3515.
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents - (Review Article)
Yang, M., Kim, J., Khan, I.A., Walker, L., Khan, S.I. 2014. Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. Life Sciences. 100:75-84.
Uplc-Ms-Elsd-Pda As a Powerful Dereplication Tool to Facilitate Compound Identification from Small Molecule Natural Product Libraries - (Peer Reviewed Journal)
Yang, J., Liang, Q., Wang, M., Jeffries, C., Smithson, D., Tu, Y., Boulos, N., Jacob, M.R., Shelat, A.A., Wu, Y., Gilbertson, R., Avery, M.A., Khan, I.A., Walker, L.A., Guy, R., Li, X. 2014. UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small molecule natural product libraries. Journal of Natural Products. 77:902-909.
Characterization of steroidal saponins from Dioscorea villosa and D Cayennensis using ultrahigh performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry - (Peer Reviewed Journal)
Avula, B., Wang, Y., Wang, M., Ali, Z., Smillie, T.J., Zweigenbaum, J., Khan, K. 2014. Characterization of steroidal saponins from Dioscorea villosa and D Cayennensis using ultrahigh performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry. Planta Medica. 80:321-329.
Chemical composition and bioactivity studies of Alpinia nigra essential oils - (Peer Reviewed Journal)
Ghosh, S., Ozek, T., Tabana, N., Aabas, A., Rehman, J., Khan, I.A., Rangan, L. 2014. Chemical composition and bioactivity studies of Alpinia nigra essential oils. Industrial Crops and Products. 53:111-119.
New secondary metabolites isolated from dondonae viscosa - (Peer Reviewed Journal)
Mostafa, A.E., El-Hela, A.A., Mohammad, A.I., Jacob, M., Cutler, S., Ross, S. 2014. New secondary metabolites isolated from dondonae viscosa. Phytochemistry Letters. 8:10-15.
Octulosonic acid derivatives from roman chamomile (Chamaemelum Nobile) with activities against inflammation and metabolic disorder - (Peer Reviewed Journal)
Zhao, J., Khan, S.I., Wang, M., Vasquez, Y., Yang, M., Avula, B., Yan-Hong, W., Avonto, C., Smillie, T.J., Khan, I.A. 2014. Octulosonic acid derivatives from roman chamomile (Chamaemelum Nobile) with activities against inflammation and metabolic disorder. Journal of Natural Products. 77:509-515.
Comparative investigation of Umbellularia californica and Laurus nobilis Leaf essential oils and identification of constituents active against Aedes aegypti - (Peer Reviewed Journal)
Tabanca, N., Avonto, C., Wang, M., Parcher, J.F., Ali, A., Demirci, B., Raman, V., Khan, I.A. 2013. Comparative investigation of Umbellularia californica and Laurus nobilis Leaf essential oils and identification of constituents active against Aedes aegypti . Journal of Agricultural and Food Chemistry. 61:12283-12291.
An integrated approach utilizing chemometrics and GC/MS for classification of chamomile flowers, essential oils and commerical products - (Peer Reviewed Journal)
Wang, M., Avula, B., Wang, Y., Zhao, J., Avonto, C., Parcher, J., Raman, V., Zweigenbaum, J., Wylie, P., Khan, I. 2014. An integrated approach utilizing chemometrics and GC/MS for classification of chamomile flowers, essential oils and commerical products. Journal of Food Chemistry. 152:391-398.
Developmental regulation of neuroligin genes in Japanese rice fish (oryzias latipes) embryogenesis maintains the rhythym during ethanol-in - (Peer Reviewed Journal)
Haron, M.H., Khan, I.A., Dasmahapatra, A.K. 2014. Developmental regulation of neuroligin genes in Japanese rice fish (oryzias latipes) embryogenesis maintains the rhythym during ethanol-in. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 159C:62-68.
Asymmetric synthesis of Crispine A: constructing tetrahydroisoquinoline scaffolds using pummerer cyclizations - (Peer Reviewed Journal)
Rotte, S.K., Chittiboyina, A.G., Khan, I.A. 2013. Asymmetric synthesis of Crispine A: constructing tetrahydroisoquinoline scaffolds using pummerer cyclizations. European Journal of Organic Chemistry. 28:6355-6360.
Nigrosphaerin A., a new isachromene derivative from the endophytic fungus Nigrospora sphaerica - (Peer Reviewed Journal)
Metwaly, A.M., Kadry, H.A., El-Hela, A.A., Mohammad, A.I., Ma, G., Culter, S.J., Ross, S.A. 2014. Nigrosphaerin A., a new isachromene derivative from the endophytic fungus Nigrospora sphaerica. Phytochemistry Letters. 7:1-5.
Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of principal component analysis to differentiate chemo-types of chamomile/chrysanthemum flowerheads - (Peer Reviewed Journal)
Avula, B., Wang, Y., Wang, M., Avonto, C., Zhao, J., Smillie, T.J., Khan, I. 2014. Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of principal component analysis to differentiate chemo-types of chamomile/chrysanthemum flowerheads. Journal of Pharmaceutical and Biomedical Analysis. 88:278-288.
Hydroxylated bisabolol oxides: evidence for secondary oxidative metabolism in Matricaria chamomilla - (Peer Reviewed Journal)
Avonto, C., Wang, M., Chittiboyina, A.G., Avula, B., Zhao, J., Khan, I.A. 2013. Hydroxylated bisabolol oxides: evidence for secondary oxidative metabolism in Matricaria chamomilla. Journal of Natural Products. 76:1848-1853.
Characterization of in vitro ADME properties of diosgenin and dioscin from dioscorea villosa - (Peer Reviewed Journal)
Manda, V.K., Bharathi, A., Ali, Z., Wang, Y., Smillie, T.J., Khan, I.A., Khan, S.I. 2013. Characterization of in vitro ADME properties of diosgenin and dioscin from dioscorea villosa. Planta Medica. 79:1421-1428.
Constituents from Terminalia species increase PPAR-Alpha and PPAR-Gamma levels and stimulate glucose uptake without enhancing adipocyte differentiation - (Peer Reviewed Journal)
Yang, M., Vasquez, Y., Ali, Z., Khan, I.A., Khan, S.I. 2013. Constituents from Terminalia species increase PPAR-Alpha and PPAR-Gamma levels and stimulate glucose uptake without enhancing adipocyte differentiation. Journal of Ethnopharmacology. 149:490-498.
Synthesis and antifungal activities of miltefosine analogs - (Peer Reviewed Journal)
Ravu, R., Chen, Y., Jacob, M.R., Pan, X., Agarwal, A.K., Khan, S.I., Heitman, J., Clark, A.M., Li, X. 2013. Synthesis and antifungal activities of miltefosine analogs. Bioorganic and Medicinal Chemistry Letters. 23:4828-4831.
Screening of medicinal plants for PPPAR-alpha and PPAR-gamma activation and evaluation of their effects on glucose uptake and 3T3-L1 adipogenesis - (Peer Reviewed Journal)
Yang, M., Avula, B., Smillie, T., Khan, I.A., Khan, S.I. 2013. Screening of medicinal plants for PPPAR-alpha and PPAR-gamma activation and evaluation of their effects on glucose uptake and 3T3-L1 adipogenesis. Planta Medica. 79:1084-1095.
Phytochemical, antimicrobial and antiplasmodial investigations of Terminalia brownii - (Peer Reviewed Journal)
Machumi, F., Midiwo, J.O., Jacob, M.R., Khan, S.I., Tekwani, B.L., Zhang, J., Walker, L.A., Muhammad, I. 2013. Phytochemical, antimicrobial and antiplasmodial investigations of Terminalia brownii. Natural Product Communications. 8(6):761-764.
Biologically active secondary metabolites from Asphodelus microcarpus - (Peer Reviewed Journal)
Ghoneim, M.M., Ma, G., El-Hela, A.A., Mohammad, A., Kottob, S., El-Ghaly, S., Cutler, S.J., Ross, S.A. 2013. Biologically active secondary metabolites from Asphodelus microcarpus. Natural Product Communications. 8(8):1117-1119.
Synthesis of pterostilbene by Julie Olefination - (Peer Reviewed Journal)
Peddikotla, P., Khan, I.A., Chittiboyina, A.G. 2013. Synthesis of pterostilbene by Julie Olefination. Synthetic Communications. 78:43-50.
Preparation and application of reversed phase chromatorotor for the isolation of natural products by centrifugal preparative chromatography - (Peer Reviewed Journal)
Ilias, M., Samoylenko, V., Machumi, F., Zaki, M.A., Gillum, V. 2013. Preparation and application of reversed phase chromatorotor for the isolation of natural products by centrifugal preparative chromatography. Journal of Chromatography A. 8(3):311-314.
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)- 3,4,3´,5´ tetramethoxystilbene isolated from Eugenia rigida - (Peer Reviewed Journal)
Mohamed, Z., Balachandran, P., Khan, S., Wang, M., Mohammed, R., Hetta, M.H., Pasco, D.S., Muhammad, I. 2013. Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)- 3,4,3´,5´ tetramethoxystilbene isolated from Eugenia rigida. Journal of Natural Products. 76:679–684.
Total bacterial load within Echinacea purpurea, determined using a new PCR-based quantification method, is correlated with LPS levels and In vitro macrophage activity - (Peer Reviewed Journal)
Pugh, N.D., Jackson, C.R., Pasco, D.S. 2012. Total bacterial load within Echinacea purpurea, determined using a new PCR-based quantification method, is correlated with LPS levels and In vitro macrophage activity. Planta Medica. 79:9-14.
Last Modified: 8/2/2014
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