Location: Genetics, Breeding, & Animal Health
Project Number: 5438-31320-012-05
Start Date: Sep 01, 2013
End Date: Aug 31, 2016
Viral neutralization assays, a measure of B cell response to viral vaccination, in combination with SNPchip genotyping will be used so that whole genome prediction can be developed to allow producers to select for cattle that are “vaccine responsive”. These will allow for the simultaneous detection of genomic regions that control genetic variation in antibody response against BVDV type 1, IBR, BRSV or IP3. We will utilize a novel antibody sequencing technique to characterize the effect of modified-live, killed and intra nasally delivered vaccines against BVDV type 1 and 2, IBR, BRSV or IP3 and subsequent BVDV type 2 viral challenge on antibody production. This same sequencing technique will be used to determine the impact of identified genomic regions on antibody production in response to viral vaccination.