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United States Department of Agriculture

Agricultural Research Service

Research Project: Creation and Preparation of Monoclonal Antibodies for Use in Biological Toxins Detection Assays

Location: Foodborne Toxin Detection and Prevention

Project Number: 2030-42000-048-06
Project Type: Reimbursable

Start Date: Mar 01, 2010
End Date: Dec 31, 2014

Objective:
To develop a panel of monoclonal antibodies that will be used to develop sensitive immunoassays for detection of multiple serotypes of botulinum neurotoxin.

Approach:
Monoclonal anti-toxin antibodies for serotypes B and E will be developed using chemical cell fusion methods following immunization with toxoids, toxins, or recombinant peptides. In addition, antibodies to nontoxin associated proteins will be developed. The monoclonal antibodies will be supplied to DHS contractors and other collaborating federal laboratories in order to format sensitive immunoassays for toxin identification. Documents Reimbursable with U.S Department of Homeland Security. Log 40768. Formerly 5325-42000-043-06R (4/11).

Last Modified: 10/31/2014
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