Location: Mid South Area (MSA)
Project Number: 6401-51000-003-02
Start Date: Sep 01, 2010
End Date: Sep 30, 2014
A prospective, randomized controlled clinical intervention will be designed, conducted, and evaluated by a multidisciplinary team of scientists from LSU AgCenter, ARS, and Pennington Biomedical Research Center (PBRC). Study participants will be overweight or obese men and women, 21-50 years of age, with a body mass index (BMI) between 29-34 kg/m2 and at least three signs of metabolic syndrome. The placebo-controlled crossover study design will consist of two intervention periods preceded by wash-out periods. Participants will be randomized to one of two study arms – placebo followed by intervention or intervention followed by placebo. At baseline and study end, overall health, cardio-metabolic risk factors, pro-inflammatory and anti-inflammatory indices, anthropometrics, body composition, satiety, dietary intake, and food cravings will be assessed. Compliance and adverse symptoms will be assessed weekly throughout the intervention periods. The primary outcomes of interest will be changes in cardio-metabolic risk factors from baseline to study end. Secondary outcomes to be evaluated will include: change in pro-inflammatory and anti-inflammatory indices, satiety, anthropometrics, body composition, and food cravings.