Effect of Diet on Immune and Physiological Changes Induced by Infection, Inflammation, and Autoimmunity, and in Relation to Chronic Disease
Diet, Genomics and Immunology Lab
Project Number: 8040-51530-056-06
Specific Cooperative Agreement
Start Date: Sep 28, 2011
End Date: Sep 27, 2016
ARS is interested in determining the impact of health-promoting components in foods including those containing probiotic bacteria and polyphenols. ARS is also interested in determining how allergens, infection, and inflammation alter intestinal immunity, physiology, and relation to development of chronic diseases, from cancer to diabetes to Alzheimers. The Cooperator directs a laboratory that has supported ARS activities to evaluate mucosal responses to pathogens and allergens and has interests in further evaluating the role of diet in the development of chronic disease.
Experimental mice and swine models of viral, bacterial, and parasitic infection, as well as exposure to allergens will be evaluated for changes in immune and physiological responses at mucosal surfaces. Cell culture studies evaluating chronic disease biomarkers and effects on brain function, as well as animal studies will be performed. This information will be used by both ARS and the Cooperator to jointly develop new research studies that focus on the evaluation of dietary and probiotic intervention to prevent the onset of inflammation and dysfunction, and enhance healthy mucosal surfaces.