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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: Polyvalent Vaccines to Protect Poultry from Avian Influenza

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Project Number: 6040-32000-062-05
Project Type: Trust

Start Date: Jan 01, 2014
End Date: Sep 30, 2015

Objective:
To evaluate the immunogenicity and efficacy of triple-hemagglutinin (HA) virus-like particles (VLPs) in poultry species as a broadly protective Avian Influenza (AI) vaccine.

Approach:
Triple-hemagglutinin (HA) virus-like particles (VLPs) will be prepared in Sf9 insect cells using baculovirus expression system, including multi-subtype H5/H7/H9 VLPs, and multi-clade H5N1 vaccine. Characteristics of multi-HA VLPs will be determined including expression levels in Sf9 cell culture, genetic stability and the ratio of HA incorporation into VLPs. Immunogenicity and efficacy of multi-HA VLP vaccines will be evaluated in chicken and turkey species. Protection against homologous and heterologous challenges will be tested including multiple strains of HPAI H5N1 virus.

Last Modified: 10/25/2014
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