Location: Jean Mayer Human Nutrition Research Center On Aging
Project Number: 8050-51000-095-001-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: May 1, 2014
End Date: Apr 30, 2019
Objective:
LAB NAME: Antioxidants Research
Objective 1. Determine the bioavailability, pharmacokinetics, metabolism, and mechanisms of phytochemicals (e.g., carotenoids, phenolic acids, polyphenols) from fruit, nuts, and whole grains using in vitro, animal model, and human studies.
Objective 2. Determine the effect of phytochemicals (e.g., alkylresorcinols, flavonoids) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., cytokines, isoprostanes), metabolomics parameters (e.g., fatty acids, organic acids), physiological profiles (e.g., endothelial responses, glucose homeostasis), and functional outcomes relevant to cardiovascular disease and type 2 diabetes.
Objective 3. Determine the effect of phytochemicals (e.g., anthocyanins, proanthocyanidins) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., oxidatively modified DNA) and physiological profiles (e.g., innate immunity) relevant to cancer, particularly colorectal and liver cancers.
Approach:
LAB NAME: Antioxidants Research
Using in vitro, animal model, and human studies, we will characterize the bioavailability, pharmacokinetics, metabolism, and mechanisms of phytochemicals (e.g., carotenoids, phenolic acids, polyphenols) from fruit, nuts, and whole grains, particularly as relevant to the aging process and older adults. Building upon this information, we will determine the effect of phytochemicals (e.g., alkylresorcinols, flavonoids) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., cytokines, isoprostanes), metabolomic parameters (e.g., fatty acids, organic acids), physiological profiles (e.g., endothelial responses, glucose homeostasis), and functional outcomes relevant to cardiovascular disease and type 2 diabetes. In addition, we will investigate the effect of phytochemicals (e.g., anthocyanins, proanthocyanidins) from fruit, nuts, and whole grains on intermediary biomarkers of age-related conditions (e.g., oxidatively modified DNA) and physiological profiles (e.g., innate immunity) relevant to cancer, particularly colorectal and liver cancers.
