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Title: SAP Minutes No. 2014-03 for FIFRA meeting held July 29-31, 2014. A set of scientific issues being considered by the Environmental Protection Agency regarding new high throughput methods to estimate chemical exposure

Author
item JENKINS, FRED - Us Environmental Protection Agency (EPA)
item BARR, DANA - Emory University
item CHEN, JAMES - Us Food & Drug Administration (FDA)
item CRONIN, MARK - John Moores University
item DELCOS, KENNETH - Us Food & Drug Administration (FDA)
item EHRICH, MARION - Virginia Polytechnic Institution & State University
item GEORGOPOULOS, PANAGIOTIS - Rutgers University
item HAYTON, WILLIAM - The Ohio State University
item JETT, DAVID - National Institutes Of Health (NIH)
item MCDONALD, PETER - McMaster University
item MCMANAMAN, JAMES - University Of Colorado
item MURPHY, CHERYL ANNE - Michigan State University
item Potter, Thomas
item SCHLENK, DANIEL - University Of California

Submitted to: Environmental Protection Agency
Publication Type: Other
Publication Acceptance Date: 10/28/2014
Publication Date: 10/28/2014
Publication URL: http://www.epa.gov/scipoly/sap/meetings/2014/072914meeting.html
Citation: Jenkins, F., Barr, D., Chen, J., Cronin, M., Delcos, K., Ehrich, M., Georgopoulos, P., Hayton, W., Jett, D., Mcdonald, P., Mcmanaman, J., Murphy, C., Potter, T.L., Schlenk, D. 2014. SAP Minutes No. 2014-03 for FIFRA meeting held July 29-31, 2014. A set of scientific issues being considered by the Environmental Protection Agency regarding new high throughput methods to estimate chemical exposure. Environmental Protection Agency. http://www.epa.gov/scipoly/sap/meetings/2014/07291meeting.html.

Interpretive Summary: USEPA convened a panel of fourteen experts to evaluate the strengths and weaknesses of their proposed approach to use High Throughput Methods to estimate chemical exposure. This includes many pesticides that are in common use. The overall goal is to develop computational tools that can assist the agency in identifying and prioritizing chemicals for testing under the agency’s Endocrine Disruptor Screening Program (EDSP). The agency has developed a framework and set of models focused on rapidly prioritizing and screening thousands of chemicals based on their potential for human and ecological exposure. It is anticipated that the models will be used to prioritize chemicals for testing under the EDSP. This report summarizes the panel’s evaluation of the agency’s methodology and provides recommendations. The agency will use the report to guide further refinement of the proposed framework and in development of new regulations and procedures to evaluate chemical exposure risks.

Technical Abstract: On July 29-31, 2014, the US Environmental Protection Agency convened a public meeting of the FIFRA Scientific Advisory Panel (SAP) to address scientific issues associated with the agency’s “new High Throughput Methods to Estimate Chemical Exposure”. EPA is proposing to use these methods to identify pesticides and other chemicals that may require further testing to determine their potential to cause endocrine disruption. The Panel provided recommendations to EPA regarding this proposal. Specifically, the Panel addressed the EPA’s charge to them on questions concerning the 3 topic areas: 1) The Systematic Empirical Evaluation of Models (SEEM) Framework for Exposure, 2) High Throughput Toxicokinetics (HTTK) and Reverse Toxicokinetics (RTK), and 3) Future Direction.