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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #241372
Title: Carbohydrate-related dietary factors and plasma adiponectin levels in healthy adults in the Framingham Offspring Cohort

Author
item MCKEOWN, NICOLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LIU, ENJU - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MEIGS, JAMES - Massachusetts General Hospital
item ROGERS, GAIL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item D'AGOSTINO, RALPH - Boston University
item JACQUES, PAUL - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 1/15/2009
Publication Date: 4/22/2009
Citation: Mckeown, N.M., Liu, E., Meigs, J.B., Rogers, G., D'Agostino, R.B., Jacques, P.F. 2009. Carbohydrate-related dietary factors and plasma adiponectin levels in healthy adults in the Framingham Offspring Cohort. Journal of Federation of American Societies for Experimental Biology. 23: 229.5.

Interpretive Summary:

Technical Abstract: Diet may influence circulating adiponectin levels by improving insulin sensitivity. We examined the associations between carbohydrate-related dietary factors and plasma adiponectin levels in healthy adults aged 26–81 y (n= 979 men and 1227 women). Dietary intakes were assessed using a FFQ. Fasting plasma adiponectin was assayed with an immunoassay kit. After adjustment for age, sex, BMI, total energy intake, current smoking status, % energy from fat and alcohol consumption, higher intakes 0of dietary fiber were positively associated with plasma adiponectin (10 % difference between highest (Q5) and lowest (Q1) quintile; p trend= 0.04), while dietary glycemic index (DGI) inversely associated with plasma adiponectin (10% difference between Q5 and Q1; p trend <0.001). A marginally significant positive association was observed between cereal fiber and whole-grain intakes and plasma adiponectin levels (p trend =0.06). However, only the association between DGI and plasma adiponectin levels remained significant after adjustment for fasting insulin. Total carbohydrate,fruit, vegetable, legume/nut fibers, glycemicload, and refined grain intakes were not associated with adiponectin levels. In conclusion, a high DGI may influence adiponectin by mechanisms independent of insulin.