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Title: Immunohistological localization of 5-HT in the CNS and feeding system of the Stable Fly

Author
item Liu, Samuel
item Li, Andrew
item WITT, COLLEEN - University Of Texas Health Science Center
item Perez De Leon, Adalberto - Beto

Submitted to: Entomological Society of America Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 9/15/2010
Publication Date: N/A
Citation: N/A

Interpretive Summary: 5-HT immunoreactive neurons were detected in the CNS of the stable fly. The finding of strong innervations of the cibarial pump muscles and the foregut by 5-HT IR neurons in the feeding-related systems suggests that 5-HT may play a crucial role in the control of the feeding behavior in both the larval and adult stages of the stable fly. Pharmacological and electrophysiological experiments are currently underway to further elucidate the functional roles of 5-HT and its receptor in stable fly feeding behavior. Most current insecticides act on a limited number of targets in the insect nervous system, but few specifically target the 5-HT receptors. Given the importance of 5-HT and 5-HT receptors in insect nervous system function and behaviors, 5-HT receptors may serve as a new molecular target for developing novel insecticides.

Technical Abstract: 5-HT immunoreactive neurons were detected in the CNS of the stable fly. The finding of strong innervations of the cibarial pump muscles and the foregut by 5-HT IR neurons in the feeding-related systems suggests that 5-HT may play a crucial role in the control of the feeding behavior in both the larval and adult stages of the stable fly. Pharmacological and electrophysiological experiments are currently underway to further elucidate the functional roles of 5-HT and its receptor in stable fly feeding behavior. Most current insecticides act on a limited number of targets in the insect nervous system, but few specifically target the 5-HT receptors. Given the importance of 5-HT and 5-HT receptors in insect nervous system function and behaviors, 5-HT receptors may serve as a new molecular target for developing novel insecticides.