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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #105811
Title: CHARACTERIZATION OF A TYPE 2 BOVINE VIRAL DIARRHEA VIRUS FOUND AS A CONTAMINANT IN A MLV VACCINE

Author
item Ridpath, Julia
item RANDALL, R - BRIDGER VET CLIN, MT
item O'TOOLE, D - WY ST. VET. LAB, LARAMIE
item CORTESE, V - PFIZER, INC., EXTON, PA
item Neill, John

Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 11/9/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Bovine viral diarrhea viruses (BVDV) may contaminate veterinary biologic Usually this is the result of using fetal bovine serum derived from infected animals as a cell culture supplement. In 1984, a modified live virus (MLV) vaccine for bovine respiratory syncitial virus (Norden seria #58, U.S. Vet. Lic. #189) was released. A total of 64 herds (more than 16,000 cattle) reported problems after one vaccination. Complaints included death (61%), fever (39%), diarrhea (32%), respiratory disease (31%), oral ulcerations (16%), and ocular discharge (8%). A BVDV2 was subsequently isolated from the vaccine. Infection with this virus alone resulted in clinically mild disease accompanied by fever (105 C) and reduced WBC (39%). Lesions were seen in the urinary and gall bladders, thymus, lymph nodes and colon. Viral antigen was seen in lymphoid cente and in arterioles. These data illustrate the threat posed by BVDV contamination of MLV vaccines.