Submitted to: World Poultry
Publication Type: Trade Journal
Publication Acceptance Date: May 18, 2000
Publication Date: November 1, 2000
Interpretive Summary: Interpretive Summary not required.
Technical Abstract: Vaccination to protect from disease from infection with avian influenza virus has been commonly practiced for many years. Current vaccines have used inactivated whole virus adjuvanted vaccines or fowlpox recombinant vaccines. Although, both of these vaccines are protective, they do have drawbacks. With the revolution in molecular biology, a variety of new and innovative vaccines have been tested that may have advantages over currently available vaccines. This review will discuss some of these new vaccines. They are generally grouped into vectored vaccines, subunit vaccines and DNA vaccines. The vectored vaccines, which include the fowlpox vectored vaccines, use the influenza hemagglutinin gene inserted into a viral vector as the vaccine. Retrovirus and Venezuelan equine encephalitis virus have been demonstrated as effective vaccines, with the VEE vector having the most potential. The subunit vaccines also use only a single influenza gene, the hemagglutinin gene, but they produce the protein in several different ways, and use the protein like a more traditional vaccine. The baculovirus insect cell system and a plant expressed system currently show the most promise for a cost effective vaccine. Finally, DNA vaccines that use bacterial grown plasmid with the hemagglutinin gene as a vaccine has been used successfully with influenza & poultry,this technology also needs further development before it can be used commercially.