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United States Department of Agriculture

Agricultural Research Service

Title: Bovine Viral Diarrhea Virus Isolated from Fetal Calf Serum Enhances Pathogenicity of Attenuated Transmissible Gastroenteritis Virus in Neonatal Pigs (Pestivirus Infection in Swine, July 2000, Ames, Iowa)

item Woods, Roger
item Kunkle, Robert
item Ridpath, Julia
item Bolin, Steven - FORMER ARS EMPLOYEE

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: April 25, 2000
Publication Date: N/A

Technical Abstract: A bovine viral diarrhea virus (BVDV-C) was isolated from swine tissue culture cells used to attenuate the transmissible gastroenteritis virus (TGEV); 68 passes. Piglets given a pure culture of BVDV-C developed clinical signs similar to that of a mild TGEV infection and recovered by ten days post exposure. Villous blunting and fusion was observed in the small intestine and a lymphocyte depletion was observed in Peyer's patches in the ileum. Piglets given a combination of BVDV-C and attenuated TGEV developed clinical signs similar to a virulent TGEV infection and were euthanized. The combine infection induced a generalized lymphocyte depletion throughout the lymphatic system along with villous atrophy in the intestinal tract. Piglets exposed to another Type I strains of BVDV (NY-1) either alone or in combination with the attenuated TGEV had mild clinical signs similar to a TGEV infection. Moderate villous atrophy in the ileum and a lymphocyte depletion in the mesenteric lymph node were observed in these piglets at post-mortem. The data indicate a potential problem for diagnostic laboratories in relation to a diagnosis of virulent TGEV infections and in the field for young piglets exposed to a BVDV contaminated TGEV vaccine.

Last Modified: 4/19/2015
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