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Title: SERUM CONCENTRATIONS OF CORTISOL, ACUTE PHASE PROTEINS AND RECTAL TEMPERATURES OF E. COLI CHALLENGED PIGS TREATED WITH ANTIBIOTICS

Author
item FANGMAN, T - UNIV OF MISSOURI
item Carroll, Jeffery - Jeff Carroll
item WIEDMEYER, C - UNIV. OF MISSOURI
item ZANNELLI, M

Submitted to: International Pig Veterinary Society (IPVS)
Publication Type: Abstract Only
Publication Acceptance Date: 6/2/2002
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Our objective was to identify changes in serum C-reactive protein (CRP), haptoglobin (HG), cortisol (CS), interferon-gamma (IFN), tumor necrosis factor-alpha (TNF), and rectal temperature (RT) in response to an acute enterotoxemia elicited by antibiotic treatment. Of 24 3-wk old pigs, 12 were non-surgically cannulated 1 d prior to blood collection. RT was monitored on the remaining 12 pigs. All pigs received 2.4 X 10**8 colony-forming units (CFU) of E. coli K88 orally. Five hr later, 6 pigs in each group were injected with either saline (.5 ml; Group A) or antibiotic (25 mg; Group B). Blood collection and RT monitoring occurred hourly from -1 hr before E. coli to 5 hr post-E. coli (PRE). From 5 to 8 hr, data collection occurred every .5 hr and at 24 hr (POST). During the PRE period, RT did not differ between groups. During the POST period, a time x treatment interaction (P<.02) was observed such that Group B had higher RT as compared to Group A. There was a time x treatment interaction (P<.0001) observed for CRP between groups. In Group B, CRP rose significantly .5 hr post-antibiotic treatment whereas in Group A, there was no additional rise. HG did not differ between groups during the PRE period. The greatest increase in HG was observed at 24 hr POST. During the PRE period, CS did not differ between groups. During the POST period, a time X treatment interaction (P=.05) was observed such that CS was higher in Group B as compared to Group A. TNF was undetectable throughout the study. During the PRE period, IFN did not change; however, IFN did increase (P<.0001) in both groups during the POST period. Identifying serum profiles that can define the immunologic status of a pig would allow veterinarians to advise producers on the most beneficial time to begin antibiotic treatment.