|Bopp, Alvin - SUNO, NEW ORLEANS, LA|
|Diegelmann, Robert - WOUND HEALING INST., VA|
|Yager, Dorne - WOUND HEALING INST., VA|
Submitted to: American Chemical Society Abstracts
Publication Type: Abstract Only
Publication Acceptance Date: March 7, 2002
Publication Date: April 8, 2002
Citation: Edwards, J.V., Bopp, A.F., Batiste, S.L., Goynes, W.R., Eggleston, G., Diegelmann, R.F., Yager, D.R. 2002. Design, Preparation and Assessment of Carbohydrate-Crosslinked Cotton Gauzes as Functional Wound Dressings [abstract]. American Chemical Society Abstracts. 223(1-2):CELL 10. Technical Abstract: We report both mono and polysaccharides on cotton wound dressing fibers as functional agents designed for a specific mode of action in chronic or burn wounds. Previously, carbohydrates as found in honey, sucrose and dextran have been used for their wound healing properties and have been either applied topically or formulated into beads and granules on the fibers of wound dressings. Carbohydrates were attached to cotton gauzes as the citrate ester of cellulose. The cellulose-citrate ester conjugates of fructose, glucose and alginate were formed on cotton gauze by rapid acid-catalyzed esterification of fibrous cellulose with citric acid as a crosslinking agent. Glucose, fructose and alginate were separately crosslinked onto cotton gauze, and the functional properties of the modified cotton fibers were examined. Glucose and fructose citrate esters were designed to target protease sequestrant activity in chronic wounds. The design is based on the open chain isomer of the hemiketal and hemiacetal of fructose and glucose which possesses partial ketone and aldehyde functionality similar to that found in synthetic elastase inhibitors. Glucose and fructose conjugates of cellulose facilitated the uptake of neutrophil elastase, a destructive protease in the chronic, non-healing wound. Alginate citrate esters were designed for absorbent and elastic wound dressing properties to accommodate joint mobility in burn wounds. The alginate-citrate modified cotton fibers retained elasticity while enhancing absorption.