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Title: BIOLOGICALLY ACTIVE POLYKETIDE METABOLITES FROM AN UNDETERMINED FUNGICOLOUS HYPHOMYCETE RESEMBLING CLADOSPORIUM

Author
item HOLLER, ULRICH - ROCHE VITAMINS, SWITZRLND
item GLOER, JAMES - U OF IA, AMES, IA
item Wicklow, Donald

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/8/2002
Publication Date: 6/1/2002
Citation: Holler, U., Gloer, J.B., Wicklow, D.T. 2002. Biologically active polyketide metabolites from an undetermined fungicolous hyphomycete resembling cladosporium. Journal of Natural Products. 65: 876-882. 2002

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of new bioactive agents useful to agriculture and medicine. An isolate of an undetermined fungus resembling Cladosporium, encountered as a colonist of the persistent fruit body of a wood-decay fungus, was examined for its ability to produce novel bioactive metabolites. Eight metabolites with a common biosynthetic origin are reported as new. Five of these compounds showed antibacterial activity.

Technical Abstract: Eight new polyketide-derived metabolites [cladoacetals A and B (1 and 2), 3-(2-formyl-3-hydroxyphenyl)propionic acid (3), 3-deoxy-isoochracinic acid (4), isoochracinol (5), 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3H)-isobenzofuranone (6), (+)-cyclosordariolone (10), and altersolanol J (11)], and six known metabolites [two isomeric 1-(1,3-dihydro-4-hydroxy-1-isobenzofuranyl)butan-2,3-diols (7a/b), 7-hydroxy-1(3H)-isobenzofuranone (8), isoochracinic acid (9), altersolanol A (12), and macrosporin (13)], have been isolated from solid-substrate fermentation cultures of an undetermined fungicolous isolate (NRRL 29097) that resembles Cladosporium sp. All structures were assigned primarily by analysis of 1D and/or 2D NMR data. Five of the compounds showed antibacterial activity.