Submitted to: Controlled Release Journal
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 11, 2006
Publication Date: October 11, 2006
Citation: Finkenstadt, V.L., Hitt, H., Willett, J.L. 2006. EXPANDED STARCH AS A FLOATING DOSAGE MATRIX FOR THE CONTROLLED RELEASE OF MODEL DRUG COMPOUNDS. Controlled Release Journal. OSF Health Summit in 2006. Interpretive Summary: Model drug compounds were blended with starch and "puffed" on an extruder to form a foamed matrix for controlled release applications. Foamed products were tested for the release of the drug compounds in a water environment and physical integrity over the life of the test. Processing conditions influenced the physical properties of the foams and the release capabilities. Foam starch products have densities lower than water and could be used for site-specific oral delivery of therapeutic agents specifically the floating dosage form. This research demonstrates that materials based on renewable resources such as starch can be used for oral controlled release devices in the biomedical field.
Technical Abstract: Starch-based materials were tested using model drug compounds to determine the feasibility of using starch as an oral floating dosage matrix. Oral controlled release systems require increased bio-availability, predictable release rates, and site-specific delivery. Starch and model drugs were compounded and blended, then "puffed" on a single screw extruder to form an expanded, low density delivery matrix. Model drug compounds were chosen for specific functionality. Materials were characterized for pore size, porosity, controlled release in an aqueous environment, and mechanical properties including buoyancy and overall strength. Extrusion conditions were found to play a role in the expansion of starch and mechanical properties for the production of a floating dosage matrix. Expanded starch showed an increase in release of model drug compounds compared to unexpanded starch.