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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #138977
Title: PROTEIN TYROSINE PHOSPHATASE 1B (PTP-1B) ACTIVATION IS DEVELOPMENTALLY REGULATED IN MUSCLE OF NEONATAL PIGS

Author
item SURYAWAN, AGUS - BAYLOR COLLEGE OF MED
item Davis, Teresa

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/20/2004
Publication Date: 4/20/2004
Citation: Suryawan, A., Davis, T.A. 2002. Protein tyrosine phosphatase 1B (PTP-1B) activation is developmentally regulated in muscle of neonatal pigs [abstract]. Federation of American Societies for Experimental Biology. Part I. 16(4):A229.

Interpretive Summary: Not Necessary for an Abstract

Technical Abstract: The high activity of the insulin signaling pathway contributes to the enhanced feeding-induced stimulation of protein synthesis in skeletal muscle of neonatal pigs. PTP-1B is a negative regulator of tyrosine phosphorylation of the insulin receptor (IR). The activity of PTP-1B is determined by its tyrosine phosphorylation, and its association with IR or Grb2. We examined the level of PTP-1B protein, tyrosine phosphorylation, and the association of PTP-1B with IR or Grb2 in muscle and liver of fed, 7 and 26 d old pigs. PTP-1B protein content in muscle was similar at 7 and 26 d; liver was higher (P< 0.05)at 7 d then 26 d. PTP-1B tyrosine phosphorylation in muscle of 7 d was lower (P< 0.05) then 26 d. The associations of PTP-1B with IR and PTP-1B with Grb2 were lower (P< 0.05) at 7 d than at 26 d in muscle but were similar in liver. These results indicate that PTP-1B activation is developmentally regulated in muscle of neonatal pig consistent with the higher activation of insulin signaling pathway. In summary, reduced PTP-1B activation likely contributes to the elevated insulin sensitivity of muscle in neonatal pigs.