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ARS Home » Research » Publications at this Location » Publication #142033
Title: VACCINATION EFFORTS WITH VIROSOMES PRODUCED FROM NEWCASTLE DISEASE VIRUS

Author
item Kapczynski, Darrell
item Tumpey, Terrence

Submitted to: Western Poultry Disease Conference
Publication Type: Abstract Only
Publication Acceptance Date: 3/9/2003
Publication Date: 6/9/2003
Citation: Kapczynski, D.R., Tumpey, T. 2003. Vaccination efforts with virosomes produced from newcastle disease virus. Western Poultry Disease Conference.

Interpretive Summary:

Technical Abstract: Outbreaks of highly virulent Newcastle disease virus (NDV) occur with regular frequency and are a major concern to the poultry industry internationally. Economic losses caused by low virulent (lentogenic) strains continue to result from decreased egg production in layers and airsacculitis in broilers. In an effort to protect chickens against NDV, we have produced NDV virosomes for use in vaccination. The virosomes do not contain replication machinery making them as safe as inactivated vaccines. However, they retain the ability to hemagglutinate chicken red blood cells and fuse with Vero cells, as would live-virus. Vaccine efficacy studies following intranasal and subcutaneous administration displayed varying degrees of protection from a lethal NDV challenge.