Submitted to: Federation of Analytical Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: June 5, 2003
Publication Date: N/A
Interpretive Summary: The Smyth line (SL) chicken is the only animal model for autoimmune vitiligo (SLV) that recapitulates the entire spectrum of clinical and biological manifestations of the human disease. Vitiligo is a common acquired hypopigmentary disorder characterized by a loss of epidermal pigment cells (melanocytes). As in many autoimmune diseases, SLV is a multifactorial disorder involving a genetic component, an immune system component and an environmental component. In this study, scientists at University of Arkansas collaborated with ARS scientists to study the role of cell-mediated immunity in SLV and the results indicated an important role of cell-mediated immunity (CMI) in SLV. The results showed interferon (IFN)gamma production in vitiliginous feathers was a factor in the pathogenesis of this disease. As IFN-gamma is a key cytokine in cell-mediated immune responses in both chickens and mammals, the presence of IFN-gamma in vitiliginous feathers further supports a role of cell-mediated immunity in SLV. This information will enhance our knowledge of autoimmune disease affecting melanocytes.
The Smyth line (SL) chicken is an animal model for autoimmune vitiligo, an acquired hypopigmentary disorder characterized by a loss of epidermal pigment cells. Evidence suggests an important role of cell-mediated in SL vitiligo (SLV) and pigment cell loss in SLV is associated with the presence of interferon gamma (IFN-gamma) in the feather. To further examine the role of IFN-gamma in the expression of SLV, SL chicks were injected twice per week for the first 6 weeks of life with recombinant chicken IFN-gamma. Vitiligo developed in 87.5% of female and 0% of male SL chicks injected with INF-gamma, suggesting a role of IFN- in SLV.