Submitted to: Book Chapter
Publication Type: Review Article
Publication Acceptance Date: December 22, 2003
Publication Date: January 25, 2004
Citation: Liu, L.S., Kramer, W.H., Fishman, M.L., Hicks, K.B. 2004. Semisynthetic composite matrices from collagen and hyaluronate for bone and cartilage regeneration. In: Chemical Reactions: Quantitative Level of Liquid and Solid Phase. Eds. Zaikov, G.E. and Jiminez, A. Hauppauge, New York: Nova Science Pudblishers, Inc. Chapter 16, p.209-229. Technical Abstract: Tissue engineering creates a three-dimensional porous matrix imitating the extracellular microenvironment for cell growth and proliferation. Naturally existing polymers are candidate components in matrix construction. This paper reviewes a new family of semisynthesized bioabsorbable matrices from two major extracellular polymers, collagen and hyaluronate. The matrices were fabricated in mild conditions into either implantable or injectable formulations, which were either devices with relatively homogenous structure or bilayer constructs consisting of two layers different in composition and architecture. Data from the in vitro and in vivo evaluations demonstrated the matrices bioabsorbable, biocompatible and osteoconductive. In combination with growth and differentiation factor-5, the bilayer matrices developed different cell phenotype in distinct layers. Thus, the new matrices have promise in tissue creation and repair.