Author
BUSH, JILL - BAYLOR COLLEGE MED | |
O'CONNOR, PAMELA - BAYLOR COLLEGE MED | |
SURYAWAN, AGUS - BAYLOR COLLEGE MED | |
ORELLANA, RENAN - BAYLOR COLLEGE MED | |
NGUYEN, HANH - BAYLOR COLLEGE MED | |
LIU, CHUN - BAYLOR COLLEGE MED | |
Davis, Teresa |
Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only Publication Acceptance Date: 3/17/2003 Publication Date: 3/1/2003 Citation: Bush, J.A., O'Connor, P.M., Suryawan, A., Orellana, R.A., Nguyen, H.V., Liu, C.W., Davis, T.A. 2003. Differential protein synthetic response in muscle and visceral tissue to somatotropin in fed growing pigs [abstract]. Federation of American Societies for Experimental Biology Conference. Part II, 17(5):A810. Interpretive Summary: Not necessary for an Abstract Technical Abstract: Somatotropin (ST) minimizes protein loss during fasting and maximizes protein gain during meal absorption in pigs. The tissue-specific effect of 7d of ST treatment (150 ug/kg/d) on fractional protein synthesis rate (Ks), capacity (Cs) and efficiency (Kma) was determined in the fasted and fed, growing pigs (n=6/grp) using 13C-leucine. Feeding increased Ks in muscle (longissimus dorsi, semitendinosus, gastrocnemius, diaphragm, masseter, heart) and in viscera (liver, spleen, kidney, intestine) of control and ST-treated pigs. ST increased Ks in muscle (LD, semitendinosus, gastrocnemius, diaphragm, heart) of fed pigs and in viscera (liver, intestine) of fasted and fed pigs. The ST-induced increase in muscle protein synthesis was largely due to increased protein synthetic efficiency, whereas the ST-induced increase in visceral protein synthesis was largely due to increased protein synthetic capacity. The results suggest that the mechanism by which ST stimulates protein synthesis is tissue-specific and is influenced by nutritional state. |