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ARS Home » Research » Publications at this Location » Publication #162173
Title: IN OVO IMMUNIZATION WITH NAKED DNAS WHICH ENCODE COCCIDIA PROTEINS ELICITS ANTIGEN SPECIFIC IMMUNE RESPONSES AGAINST EIMERIA.

Author
item DING, XICHENG - USDA,ARS,ANRI,APDL
item Lillehoj, Hyun
item QUEROZ, MARCO - AVITECH HEBRON MD
item BEVENSEE, ERICH - AVITECH HEBRON MD

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/30/2004
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Eighteen-day-old SPF embryos were injected with a naked DNA which encodes an immunogenic coccidia protein using the Intelliject, an in ovo injector. Eimeria-antigen specific serum antibodies were detected after hatch. At 14 days post hatch, in ovo-vaccinated chickens were challenged with live Eimeria oocysts, and their fecal oocyst count and body weights were compared to those of untreated control group. In ovo-vaccinated chickens showed significantly lower fecal oocyst counts and improved body weight gains compared to the untreated chickens. These studies show promising results on using in ovo vaccination strategy to elicit protective intestinal immune response against coccidiosis.