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United States Department of Agriculture

Agricultural Research Service

Title: Enhancement of Disease and Pathology by Synergy of Trichuris Suis and Campylobacter Jejuni in the Colon of Immunologically Naive Swine

Authors
item Mansfield, Linda - MSU EAST LANSING MI
item Gauthier, David - MSU EAST LANSING MI
item Abner, Sheila - MSU EAST LANSING MI
item Jones, Kathryn - MSU EAST LANSING MI
item Wilder, Stacey - MSU EAST LANSING MI
item Urban, Joseph

Submitted to: American Journal of Tropical Medicine and Hygiene
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: July 9, 2003
Publication Date: August 25, 2003
Citation: Mansfield, L., Gauthier, D., Abner, S., Jones, K., Wilder, S., Urban Jr, J.F. 2003. Enhancement of disease and pathology by synergy of trichuris suis and campylobacter jejuni in the colon of immunologically naive swine. American Journal of Tropical Medicine and Hygiene 68(1):70-80 (2003)

Interpretive Summary: Immunity to nematode parasites is characterized by an immediate type hypersensitivity reaction that can expel worms from the intestine without dramatic effects on the equilibrium of the host. There are consequences to this reaction, however, that may result in interference with immunity to bacterial, viral and protozoan infections. This is because the nature of the immune response to worm versus bugs is different, and these responses often counter regulate the efficiency of the other. This concept of counter regulation and consequences of mixed infections with worms and bacteria was demonstrated by treating new born pigs with an immature immune system with whip worms and bacteria. Campylobacter bacteria are common and can cause severe diarrhea when inadvertently ingested in contaminated foods. The study shows that the combined exposure exacerbates the bacterial infection and causes disease in the piglets that is more severe than when each infection is given alone. This study will have impact on strategies to control worm infection by therapy or management in both livestock and humans, and can make the treatment of campylobacter infection more efficient. Scientists and clinicians interested in these infectious agents and control of disease severity will benefit from this information.

Technical Abstract:

Last Modified: 4/17/2015
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