ARS | Publication request: HYDROXYPROPYLMETHYLCELLULOSE (HPMC) PREVENTS INSULIN RESISTANCE IN HAMSTERS FED HIGH HIGH SATURATED FAT DIETS THROUGH REGULATION OF METABOLIC GENES

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 13, 2005
Publication Date: March 13, 2005
Citation: Shao, Q., Wlaschin, K., Yokoyama, W.H., Nissom, P.M., Yap, M., Hu, W., Lazo, G.R. 2005. Hydroxypropylmethylcellulose (hpmc) May Prevent Insulin Resistance in Hamsters Fed High Saturated Fat Diets through Regulating Metabolic Genes. Meeting Abstract Paper AGFD #103, ACS Cornucopia, 3/15/05, San Diego, CA.

Technical Abstract: Syrian hamsters fed a high fat (HF) diet similar in fat content to the American diet become insulin resistant (IR). We have shown earlier that replacing cellulose in this HF diet with hydroxypropylmethylcellulose (HPMC) significantly decreases the incidence of IR. HPMC significantly reduced the glucose infusion rate, fasting plasma insulin, plasma lipids, overall fat distribution in non-adipose tissues, and the cell size of adipose tissues. The underlying mechanisms of these beneficial physiological effects are unknown. A cDNA microarray, constructed from Chinese hamster ovary cells, was used to analyze gene expression in liver tissues from hamsters fed the HF or the HF with HPMC diets. Genes related to fat metabolism, glucose metabolism, insulin metabolism, inflammation and glucose transport, were differentially expressed between the two groups. These results indicate that HPMC may prevent the cellular oxidative damage leading to diabetes by normalizing fat metabolism.