Technical Abstract: Proper crop rotation is essential to maintaining high peanut yield and quality. However, the economic considerations of maintaining or altering crop rotation sequences must incorporate the commodity prices, production costs, and yield responses of all crops in, or potentially in, the crop rotation system. Certain commodity price combinations could exist that warrant shortening rotation sequences from a profit maximization standpoint that would be in direct conflict with agronomic recommendations. Farmers must be able to make these decisions within the scope of a single production season as well as knowing the longer-term impact on profitability of potential cropping systems. Proper farm planning and crop rotation response data are two essential elements that are prerequisite for farmers to adequately assess the economic and agronomic impacts of potentially changing crop rotation sequences. To address these elements, a large-scale irrigation and crop rotation research project was established in CY 2001. Five replicated irrigated and non-irrigated cropping sequences including peanuts, cotton, and corn were defined as: continuous peanuts (PPP), cotton/peanuts/cotton (CPC), corn/peanuts/corn (MPM), cotton/cotton/peanuts (CCP), and cotton/corn/peanuts (CMP). The peanut yield in the PPP rotation was 2945 kg ha-1 in the non-irrigated treatment. Non-irrigated yields in CPC and MPM rotation sequences were 3512 and 3469 kg ha-1, respectively and yields in CCP and CMP rotation sequences were 4252 and 4201 kg ha-1, respectively. The peanut yield in the PPP rotation was 3636 kg ha-1 in the irrigated treatment. Irrigated yields in CPC and MPM rotation sequences were 4714 and 4669 kg ha-1, respectively and yields in CCP and CMP rotation sequences were 5295 and 5365 kg ha-1, respectively. The economic impacts of changing rotations can be quantified using the WHOLEFARM whole farm planning software. A new breakeven cross-commodity price matrix (CCPM) has been incorporated into WHOLEFARM to calculate the price change for a specific that is required to make equal in profitability to other commodities. I addition, the CCPM can be used directly calculate the price changes that would be required to justify shortening peanut rotation sequences.