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Title: EXPRESSION OF TGF-BETA FAMILY OF LIGANDS IS DEVELOPMENTALLY REGULATED IN SKELETAL MUSCLE OF NEONATAL RATS

Author
item SURYAWAN, AGUS - BAYLOR COLL OF MEDICINE
item FRANK, JASON - BAYLOR COLL OF MEDICINE
item NGUYEN, HANH - BAYLOR COLL OF MEDICINE
item LIU, WILLIAM - BAYLOR COLL OF MEDICINE
item Davis, Teresa

Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 1/19/2005
Publication Date: 4/2/2005
Citation: Suryawan, A., Frank, J.W., Nguyen, H.V., Liu, W. Davis, T.A. 2005. Expression of TGF-Beta family of ligands is developmentally regulated in skeletal muscle of neonatal rats [abstract]. The Federation of American Societies for Experimental Biology Conference. Part II(abstract 579.2):A985.

Interpretive Summary: Not Required for an Abstract.

Technical Abstract: The growth of skeletal muscle is in part governed by growth factors that act as positive and negative regulators. To dissect the possible role of these growth factors on skeletal muscle development during the neonatal period, the coordinated expression of the transforming growth factor-beta (TGF-Beta) family of ligands, their receptors and inhibitor (follistatin) were determined in skeletal muscle of neonatal rats at different ages by Western blotting. The relationship between the abundances of these growth factors and muscle protein synthesis, an important indicator for muscle growth, was also examined. The abundance of TGF-Beta2 decreased with development, and was positively correlated with protein synthesis (r[2]=0.72; P<0.05). The abundances of bone-morphogenetic protein-2, -7 (BMP-2, BMP-7), and myostatin increased with development, and were negatively correlated with protein synthesis (r[2]=0.86; P<0.05), (r[2]=0.71; P<0.05) and (r[2]=0.74; P<0.05), respectively. The abundances of activin A, follistatin, activin receptor IIB (ActRIIB) and BMP receptor IA (BMPRIA) were also developmentally regulated, consistent with their physiological role as regulators of muscle growth. These results suggest that the TGF-Beta family of ligands may be important regulators of muscle protein synthesis, and thus muscle growth, in neonatal animals.