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United States Department of Agriculture

Agricultural Research Service

Title: Influence of the Spirovac(r) Leptospirosis Vaccine on Immunologic Responses of Bison to Brucella Abortus Strain Rb51 Vaccine

Authors
item Olsen, Steven
item Stoffregen, William
item Zuerner, Richard
item Alt, David

Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: November 14, 2004
Publication Date: November 14, 2004
Citation: Olsen, S.C., Stoffregen, W.C., Zuerner, R.L., Alt, D.P. 2004. Influence of the spirovac(r) leptospirosis vaccine on immunologic responses of bison to brucella abortus strain rb51 vaccine [abstract]. Research Workers in Animal Diseases Conference Proceedings. p.98.

Interpretive Summary: Brucella abortus is a disease that causes abortion and associated economic losses in infected cattle herds. The infection of bison with Brucella abortus in Yellowstone National Park pose a risk to the completion of the Brucellosis Eradication Program for cattle. A safe and efficacious vaccine for bison within Yellowstone National Park is needed and would be beneficial in resolving the controversy caused by brucellosis in bison. In this study, we another vaccine as a possible adjuvant to enhance bison immunologic responses to the RB51 brucellosis vaccine. Our data suggest this vaccine did not influence immunologic responses of bison to RB51. This data will be of benefit to the National Park Service and the states of Montana, Wyoming, and Idaho in their efforts to resolve the brucellosis problem in the Yellowstone National Park bison. Maximizing the efficacy of a brucellosis vaccine for bison will help prevent transmission of brucellosis to cattle herds and assist in the completion of the Brucellosis Eradication Program

Technical Abstract: The prevalence of brucellosis in bison within Yellowstone National Park in the United States has raised concerns in regards to possible transmission to domestic livestock. The purpose of the study reported here was to determine if a leptospirosis vaccine that induces strong cell-mediated responses in cattle might influence immunologic responses of bison to vaccination with a brucellosis vaccine. Bison were randomly assigned to saline (control), Spirovac, 1 x 10^10 CFU Brucella abortus strain RB51 (SRB51), or SRB51 combined Spirovac treatments. Immunologic responses evaluated included: antibody responses, proliferative responses to killed SRB51, gamma interferon production, nitric oxide production, and flow cytometric analysis of proliferating PBMC subsets. Antibody and rroliferative responses to SRB51 were not influenced by co-administration of Spirovac. However, proliferative responses to leptospirosis antigens were greatest in bison vaccinated only with Spirovac. At this time, our data suggests that immunologic responses of bison to SRB51 are not influenced by co-administration of Spirovac

Last Modified: 11/21/2014
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