Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: January 17, 2006
Publication Date: July 16, 2006
Citation: Suarez, D.L., Spackman, E., Pantin Jackwood, M.J., Swayne, D.E. 2006. Biological and molecular characterization of recent Asian H5N1 strains [abstract]. American Association of Avian Pathologists. CD p. 74. Technical Abstract: Highly pathogenic H5N1 avian influenza has continued to spread in Asia and recently into Eastern Europe. Although all these viruses have a common ancestor for the hemagglutinin gene, two distinct genetic lineages have been recently characterized. A virus from a wild bird from Mongolia appear to be a good representative of one of the lineages and is closely related to viruses isolated from Russia and Eastern Europe. The other lineage will also be examined by analyzing viruses from Vietnam. Sequence analysis, biological characterization, and antigenic analysis will be performed to evaluate the diversity of viruses in the region. An evaluation of how these differences may affect control by vaccination will be discussed.