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United States Department of Agriculture

Agricultural Research Service

Research Project: FUNGAL ENDOPHYTES OF MAIZE: GENE PRODUCTS CONFERRING RESISTANCE TO AFLATOXIN AND FUMONISIN Title: Kolokosides a-D: Triterpenoid Glycosides from a Hawaiian Isolate of Xylaria Sp.

item Deyrup, Stephen - UNIVERSITY OF IOWA
item Gloer, James - UNIVERSITY OF IOWA
item O`donnell, Kerry
item Wicklow, Donald

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 31, 2006
Publication Date: February 7, 2007
Citation: Deyrup, S.T., Gloer, J.B., O Donnell, K., Wicklow, D.T. 2007. Kolokosides A-D: Triterpenoid glycosides from a Hawaiian isolate of Xylaria sp. Journal of Natural Products. 70(3):378-382.

Interpretive Summary: Fungi adapted to long-term survival in arid environments offer a potential source of novel antifungal agents useful to agriculture and medicine. The wood decay fungus Xylaria sp. NRRL 40192, collected in a montane dry forest near Kailua-Kona, Hawaii, was examined for its ability to produce antifungal agents and other bioactive metabolites. Four new triterpenoid glycosides, kolokosides A-D, are reported. Kolokoside A exhibited antibacterial activity against Bacillus subtilis and Staphylococcus aureus.

Technical Abstract: Four new triterpenoid glycosides, kolokosides A-D (1-4), along with the known compound 19, 20-epoxycytochalasin N, were isolated from cultures of a Hawaiian wood-decay fungus (Xylaria sp.) The structures and relative configurations of 1-4 were determined primarily by analysis of NMR data, and the absolute configuration of 1 was assigned by application of the exciton chirality method. Compound 1 exhibited activity against gram-positive bacteria.

Last Modified: 4/22/2015
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