Technical Abstract: The topic of natural products as pesticides is reviewed, with a discussion of the advantages and disadvantages of adopting a natural product-based strategy for pesticide discovery. Current and past natural product and natural product-based herbicides, insecticides, fungicides, molluscicides, rodenticides, algicides, and nematicides are discussed, giving examples of each. Finally, the potential for genetically engineering synthesis of natural product pesticides into crops is critiqued. Natural products are a unique resource for pest management that we have only begun to utilize.