Author
ENDSLEY, JANICE - UNIV. OF TX MED. BR. | |
HOGG, ALISON - INST. FOR AN. HEALTH, UK | |
SHELL, LIS - UNIV. OF TX MED. BR. | |
MCALAUY, MARTIN - INST. FOR AN. HEALTH, UK | |
SCHERER, CHARLES - UNIV. OF TX MED. BR. | |
COFFEY, TRACEY - INST. FOR AN. HEALTH, UK | |
HOWARD, CHRIS - INST. FOR AN. HEALTH, UK | |
Nonnecke, Brian | |
Waters, Wade | |
ESTES, D - UNIV. OF TX MED. BR. |
Submitted to: Meeting Abstract
Publication Type: Abstract Only Publication Acceptance Date: 5/18/2007 Publication Date: 5/18/2007 Citation: Endsley, J.J., Hogg, A., Shell, L., Mcalauy, M., Scherer, C.C., Coffey, T., Howard, C., Nonnecke, B.J., Waters, W.R., Estes, D.M. 2007. Biomarkers of CD4+ CTL cell Mediated Immunity to Tuberculosis [abstract]. American Association of Imunologists. p. 43.49. Interpretive Summary:
Technical Abstract: The immune responses mediated by interactions between T-lymphocyte subsets and mycobacteria-infected macrophages are critical for control of tuberculosis. In these studies, the bovine model was used to characterize the cytolytic and mycobactericidal CD4+ T cell response induced by BCG vaccination. Antigenic stimulation of CD4+ T-cells from BCG vaccinated cattle induced expression of perforin and IFNgamma in cells expressing a CD45RA-, CD45RO+, and CD62L+ cell surface phenotype. Antigen specific enhancement of granulysin, IFNgamma, perforin, IL-4, IL-13, and IL-21 mRNA expression was detected and not detected for IL-2, IL-6, IL-10, IL-15, TNF {alpha} |